UGA

URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID

Created:	1999-12-13
Last modified:	2021-03-01

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18 entries where UGA is found as a standalone ligand1 entries where UGA is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	59
Chiral Atom Count	11
Bond Count	61
Aromatic Bond Count	6

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Chemical Component Summary
Name	URIDINE-5'-DIPHOSPHATE-GLUCURONIC ACID
Synonyms	UDP-GLUCURONIC ACID
Systematic Name (OpenEye OEToolkits)	(2S,3S,4S,5R,6R)-6-[[[(2R,3S,4R,5R)-5-(2,4-dioxopyrimidin-1-yl)-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxy-hydroxy-phosphoryl]oxy-3,4,5-trihydroxy-oxane-2-carboxylic acid
Formula	C₁₅ H₂₂ N₂ O₁₈ P₂
Molecular Weight	580.285
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C3OC(OP(=O)(O)OP(=O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)C(O)C2O)C(O)C(O)C3O
SMILES	CACTVS	3.341	O[CH]1[CH](O)[CH](O[CH]([CH]1O)C(O)=O)O[P](O)(=O)O[P](O)(=O)OC[CH]2O[CH]([CH](O)[CH]2O)N3C=CC(=O)NC3=O
SMILES	OpenEye OEToolkits	1.5.0	C1=CN(C(=O)NC1=O)C2C(C(C(O2)COP(=O)(O)OP(=O)(O)OC3C(C(C(C(O3)C(=O)O)O)O)O)O)O
Canonical SMILES	CACTVS	3.341	O[C@@H]1[C@@H](O)[C@H](O[C@@H]([C@H]1O)C(O)=O)O[P@@](O)(=O)O[P@@](O)(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)N3C=CC(=O)NC3=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO[P@@](=O)(O)O[P@@](=O)(O)O[C@@H]3[C@@H]([C@H]([C@@H]([C@H](O3)C(=O)O)O)O)O)O)O
InChI	InChI	1.03	InChI=1S/C15H22N2O18P2/c18-5-1-2-17(15(26)16-5)12-9(22)6(19)4(32-12)3-31-36(27,28)35-37(29,30)34-14-10(23)7(20)8(21)11(33-14)13(24)25/h1-2,4,6-12,14,19-23H,3H2,(H,24,25)(H,27,28)(H,29,30)(H,16,18,26)/t4-,6-,7+,8+,9-,10-,11+,12-,14-/m1/s1
InChIKey	InChI	1.03	HDYANYHVCAPMJV-LXQIFKJMSA-N

Drug Info: DrugBank

DrugBank ID	DB03041
Name	UDP-alpha-D-glucuronic acid
Groups	experimental
Description	A nucleoside diphosphate sugar which serves as a source of glucuronic acid for polysaccharide biosynthesis. It may also be epimerized to UDP iduronic acid, which donates iduronic acid to polysaccharides. In animals, UDP glucuronic acid is used for formation of many glucosiduronides with various aglycones. [PubChem]
Synonyms	uridine diphosphate glucuronic acid Uridine-5'-diphosphate-glucuronic acid UDP-alpha-D-glucuronate UDPglucuronate UDP-D-glucuronate UDP-alpha-D-glucuronic acid UDP-glucuronate UDP-Glucuronic Acid
Categories	Carbohydrates Glycosides Nucleic Acids, Nucleotides, and Nucleosides Nucleoside Diphosphate Sugars Nucleotides Pyrimidine Nucleotides Pyrimidines Ribonucleotides Uracil Nucleotides Uridine Diphosphate Uridine Diphosphate Sugars
CAS number	2616-64-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
UDP-glucose 4-epimerase	MAEKVLVTGGAGYIGSHTVLELLEAGYLPVVIDNFHNAFRGGGSLPESLR...	unknown	substrate
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3	MKLKLKNVFLAYFLVSIAGLLYALVQLGQPCDCLPPLRAAAEQLRQKDLR...	unknown
UDP-glucose 6-dehydrogenase	MKIAVAGSGYVGLSLGVLLSLQNEVTIVDILPSKVDKINNGLSPIQDEYI...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682