TE4

Tetracaine

Created:	2014-02-11
Last modified:	2021-03-01

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6 entries where TE4 is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	43
Chiral Atom Count	0
Bond Count	43
Aromatic Bond Count	6

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Chemical Component Summary
Name	Tetracaine
Synonyms	2-(dimethylamino)ethyl 4-(butylamino)benzoate
Systematic Name (OpenEye OEToolkits)	2-(dimethylamino)ethyl 4-(butylamino)benzoate
Formula	C₁₅ H₂₄ N₂ O₂
Molecular Weight	264.363
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	O=C(OCCN(C)C)c1ccc(NCCCC)cc1
SMILES	CACTVS	3.385	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
SMILES	OpenEye OEToolkits	1.7.6	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Canonical SMILES	CACTVS	3.385	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
Canonical SMILES	OpenEye OEToolkits	1.7.6	CCCCNc1ccc(cc1)C(=O)OCCN(C)C
InChI	InChI	1.03	InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3
InChIKey	InChI	1.03	GKCBAIGFKIBETG-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB09085
Name	Tetracaine
Groups	approved vet_approved
Description	Tetracaine is an ester local anaesthetic currently available in combination with lidocaine as a cream and patch.
Synonyms	Metraspray Tetracaine HCl Amethocaine Dicaine Diäthylaminoäthanol ester der p-butylaminobenzösäure Amethocaine HCl 2-(dimethylamino)ethyl 4-(butylamino)benzoate Tetracaine Tetracaína p-(butylamino)benzoic acid β-(dimethylamino)ethyl ester Tétracaïne Medihaler-Tetracaine Tetracaine hydrochloride p-Butylaminobenzoyl-2-dimethylaminoethanol 2-(Dimethylamino)ethyl p-(butylamino)benzoate
Brand Names	Pontocaine Blt 3 Cutiecaine Zap Topical Anesthetic Gel Pontocaine Pws Inj 20mg/amp Lidocaine 7% / Tetracaine 7% One Touch Advanced Topical Anesthetic Bubble Gum Ndc 72934- 5010-4 Benzocaine 20% / Lidocaine 8% / Tetracaine 4%. Tetracaine2 Supracaine Aerosol 11.6mg/gm Cetacaine Anesthetic Denti-Care Denti-Freeze Topical Anesthetic Strawberry Denti-care Topical Anesthetic Gel One Touch Advanced Topical Anesthetic Cherry Plush anesthetics T FranklyNumb 3 BLT Skin Cream Pontocaine 5 mg/ml Exactacain Topical Anesthetic Zap Topical Anesthetic Spray Inderma MD Niphanoid Comfortox Tetracaine Spinal Anaesthesia Tray TetraVisc Forte Blue Gel Anesthetic T.R.U.E. Test Thin-Layer Rapid Use Patch Test Viractin Gel Cetacaine Topical Anesthetic Supracaine Aem 754mg/65gm Denti-Care Denti-Freeze Topical Anesthetic Cherry Numfast Tetracaine Green Tetracaine (Base) Ametop Gel 4% One Touch Advanced Topical Anesthetic Gel Cool Mint Ritual Tattoo Reveal Foam Synera NeuroMed LA One Touch Advanced Topical Anesthetic Strawberry Ice Cetacaine Liquid Eclipse Topical Analgesic LL Minims Tetracaine Hydrochloride Henry Schein Topical Anesthetic Gel TetraVisc Tetracaine Hydrochloride NeuroMed Topical Analgesic LA Spinal Anesthesia Tray Panocaine Gel Tetragel Punch Topical Analgesic Burn Cream Altacaine Sj3 Blockaid Pliaglis Denti-Care Denti-Freeze Topical Anesthetic Mint Tetracaine HCL Tetramex Lidocaine 23% / Tetracaine 7% Tetracaine Zap Liquid Penichillin Denti-Care Denti-Freeze Topical Anesthetic Bubblegum Painless Tattoo 3 Viractin Moisturizing Cream Denticare Pro-freeze Kovanaze One Touch Topical Anesthetic Gel Cetacaine Spray Pro Plus tetraVIV Advanced Cold Sore Care Pontocaine Dps 0.5% Burn Solution Cream Zap Topical Anesthetic Spray Aerosol Denti-care Topical Anesthetic Liquid Spray Denti-Care Denti-Freeze Topical Anesthetic Raspberry Super T Ritual Tattoo Endospray Dermacaine-R Lidocaine and Tetracaine Pain Prescriptives Topical Analgesic LL Benzocaine 20% / Lidocaine 10% / Tetracaine 10%
Indication	Ophthalmic tetracaine is indicated for the for procedures requiring a rapid and short- acting topical ophthalmic anesthetic. The combination lidocaine and tetracaine patch is indicated for local dermal analgesia for superficial dermatological procedures and superficial venous access. The combination lidocaine and tetracaine cream is intended to provide topical local analgesia for superficial dermatological procedures.
Categories	Acids, Carbocyclic Agents for Treatment of Hemorrhoids and Anal Fissures for Topical Use Aminobenzoates Anesthetics Anesthetics for Topical Use Anesthetics, General Anesthetics, Local Antipruritics and Local Anesthetics Antipruritics, Incl. Antihistamines, Anesthetics, Etc. Benzene Derivatives Benzoates Central Nervous System Agents Central Nervous System Depressants Dental Agents Dermatologicals Esters of Aminobenzoic Acid Local Anesthesia Local Anesthetics (Ester) Methemoglobinemia Associated Agents Nervous System Ophthalmologicals para-Aminobenzoates Peripheral Nervous System Agents Sensory Organs Sensory System Agents Vasoprotectives
ATC-Code	C05AD02 N01BA03 D04AB06 N01BA53 S01HA03
CAS number	94-24-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Ryanodine receptor 1	MGDAEGEDEVQFLRTDDEVVLQCSATVLKEQLKLCLAAEGFGNRLCFLEP...	unknown	modulator
Ryanodine receptor 2	MADGGEGEDEIQFLRTDDEVVLQCTATIHKEQQKLCLAAEGFGNRLCFLE...	unknown	modulator
Voltage-gated sodium channel alpha subunit	MEQTVLVPPGPDSFNFFTRESLAAIERRIAEEKAKNPKPDKKDDDENGPK...	unknown	blocker

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682