SIN

SUCCINIC ACID

Created:	1999-07-08
Last modified:	2024-09-27

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285 entries where SIN is found as a standalone ligand13 entries where SIN is covalently linked to polymer or other heterogen groups 27 entries where SIN is found in a polymer sequence

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Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	0
Bond Count	13
Aromatic Bond Count	0

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Chemical Component Summary
Name	SUCCINIC ACID
Systematic Name (OpenEye OEToolkits)	butanedioic acid
Formula	C₄ H₆ O₄
Molecular Weight	118.088
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	O=C(O)CCC(=O)O
SMILES	CACTVS	3.370	OC(=O)CCC(O)=O
SMILES	OpenEye OEToolkits	1.7.0	C(CC(=O)O)C(=O)O
Canonical SMILES	CACTVS	3.370	OC(=O)CCC(O)=O
Canonical SMILES	OpenEye OEToolkits	1.7.0	C(CC(=O)O)C(=O)O
InChI	InChI	1.03	InChI=1S/C4H6O4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)(H,7,8)
InChIKey	InChI	1.03	KDYFGRWQOYBRFD-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00139
Name	Succinic acid
Groups	approved nutraceutical
Description	A water-soluble, colorless crystal with an acid taste that is used as a chemical intermediate, in medicine, the manufacture of lacquers, and to make perfume esters. It is also used in foods as a sequestrant, buffer, and a neutralizing agent. (Hawley's Condensed Chemical Dictionary, 12th ed, p1099; McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed, p1851)
Synonyms	Bernsteinsäure Succinic acid Acidum succinicum Dihydrofumaric acid Butanedionic acid 1,2-ethanedicarboxylic acid Acide succinique Butanedioic acid Asuccin Acide butanedioïque Butandisäure Amber acid Spirit of amber Ethylenesuccinic acid
Brand Names	Iron Aspartate Glycinate and Polysaccharide Complex, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid Ferrex 28 FeRiva 21 7 Iron Aspartate, Glycinate, Ascorbic Calcium, Vitamin B12, Calcium Threonate and Succinic Acid Niferex Ferrex 150 Forte Plus Irospan 24/6 Iron Fumarate and Aspartate, Glycinate, Ascorbic Calcium, Vitamin B12, Folic Acid, Calcium Threonate and Succinic Acid Ferrex 150 Plus Se-Vate 21/7
Indication	For nutritional supplementation, also for treating dietary shortage or imbalance
Categories	Acids, Acyclic Dicarboxylic Acids Dietary Supplements OAT3/SLC22A8 Substrates Succinates Supplements
CAS number	110-15-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Succinate-semialdehyde dehydrogenase, mitochondrial	MATCIWLRSCGARRLGSTFPGCRLRPRAGGLVPASGPAPGPAQLRCYAGR...	unknown	inhibitor
Succinate receptor 1	MLGIMAWNATCKNWLAAEAALEKYYLSIFYGIEFVVGVLGNTIVVYGYIF...	unknown
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	MAALLLRHVGRHCLRAHFSPQLCIRNAVPLGTTAKEEMERFWNKNIGSNR...	unknown	substrate
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	MSGVRGLSRLLSARRLALAKAWPTVLQTGTRGFHFTVDGNKRASAKVSDS...	unknown	substrate
Succinyl-CoA ligase [GDP-forming] subunit beta, mitochondrial	MASPVAAQAGKLLRALALRPRFLAAGSQAVQLTSRRWLNLQEYQSKKLMS...	unknown	product of
Prolyl 4-hydroxylase	MIWYILIIGILLPQSLAHPGFFTSIGQMTDLIHTEKDLVTSLKDYIKAEE...	unknown	product of
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	MTSSGPGPRFLLLLPLLLPPAASASDRPRGRDPVNPEKLLVITVATAETE...	unknown	product of
Prolyl 3-hydroxylase 1	MAVRALKLLTTLLAVVAAASQAEVESEAGWGMVTPDLLFAEGTAAYARGD...	unknown	product of
Prolyl 3-hydroxylase 2	MRERIWAPPLLLLLPLLLPPPLWGGPPDSPRRELELEPGPLQPFDLLYAS...	unknown	product of
Prolyl 3-hydroxylase 3	MLRLLRPLLLLLLLPPPGSPEPPGLTQLSPGAPPQAPDLLYADGLRAYAA...	unknown	product of
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial	MAALKLLSSGLRLCASARGSGATWYKGCVCSFSTSAHRHTKFYTDPVEAV...	unknown	product of
Aspartyl/asparaginyl beta-hydroxylase	MAQRKNAKSSGNSSSSGSGSGSTSAGSSSPGARRETKHGGHKNGRKGGLS...	unknown	product of
Solute carrier family 22 member 8	MTFSEILDRVGSMGHFQFLHVAILGLPILNMANHNLLQIFTAATPVHHCR...	unknown	substrate
Mitochondrial dicarboxylate carrier	MAAEARVSRWYFGGLASCGAACCTHPLDLLKVHLQTQQEVKLRMTGMALR...	unknown	ligand
Solute carrier family 13 member 1	MKFFSYILVYRRFLFVVFTVLVLLPLPIVLHTKEAECAYTLFVVATFWLT...	unknown	inhibitor
Solute carrier family 13 member 2	MATCWQALWAYRSYLIVFFVPILLLPLPILVPSKEAYCAYAIILMALFWC...	unknown	substrate
Solute carrier family 13 member 3	MAALAAAAKKVWSARRLLVLLFTPLALLPVVFALPPKEGRCLFVILLMAV...	unknown	substrate
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
PubChem	21952380, 1110
ChEMBL	CHEMBL576
ChEBI	CHEBI:15741
CCDC/CSD	EFAPUY, DIKCIK, DICYIA, ENICOU01, FADGIC, CIRXAD, DUWLAK, EXIPEH, CEJXOF, GABZUF, GAWLOG, AXUFIJ, BULGEU, DILVAX, FIDCIG, HAGNEJ, GESBAJ, FADGIC03, GALBIF, BIQTON, DUFJIA01, CUVDUT, DUFJIA, BICQAH, ENICOU, CIWFUL, EWOZIZ, FADGIC02, FOTFOL, DOSZAO, ACESUY, EMAPIT, DUZPAQ, GOKBAL, FAGXOB, AVEKAN, CUJMIE, EXIPEH01, EYECIW, GADBEV, GOKBAL01, CAKZUL, BEPTIB, FOTDID, FOTDAV, BZASUC, EVATAZ, EZAQOO, AQOMIF
COD	7214503, 7217968, 2019656, 7214504, 7217969, 7214484, 7217949, 4507999, 4508000, 7214505, 7217970, 7214485, 7217950, 7214501, 7217966, 4507998, 4508001, 4508002, 4508003, 7214502, 7217967, 7214486, 7217951, 7214483, 7217948, 7214500, 7217965, 7214481, 7217946, 7208190, 7205837, 4501989, 7214482, 7217947, 7214480, 7217945, 7205836, 2101616, 2207898, 1520258, 7200947, 7208516