Piperazine is an organic compound that consists of a six-membered ring containing two opposing nitrogen atoms. First used as a solvent for uric acid, the use of piperazine as an anthelmintic agent was first introduced in 1953. Upon entry into the systemic circulation, the drug is partly oxidized and partly eliminated as an unchanged compound. Outside the body, piperazine has a remarkable power to dissolve uric acid and producing a soluble urate, but in clinical experience it has not proved equally successful. Piperazine was first introduced as an anthelmintic in 1953. Piperazine compounds mediate their anthelmintic action by generally paralyzing parasites, allowing the host body to easily remove or expel the invading organism.
Synonyms
Piperazidine
Piperazine
Piperazine hydrate
Piperazin
Piperazine citrate
Piperazina
Piperazine sulfate
Piperazine hydrochloride
Diethylenediamine
Piperazine hexahydrate
Piperazine adipate
Piperazine phosphate
Piperazine monohydrochloride
Brand Names
Formule C34
Veriga 125
Entacyl Granules
Entacyl Suspension-600mg/5ml
Vermirex Syr
Versol 100mg
Entacyl Susp 0.6gm/5ml
Entacyl Granules 2.0gm
Indication
Used as alternative treatment for ascariasis caused by <i>Ascaris lumbricoides</i> (roundworm) and enterobiasis (oxyuriasis) caused by <i>Enterobius vermicularis</i> (pinworm). It is also used to treat partial intestinal obstruction by the common roundworm, a condition primarily occurring in children.
Categories
Anthelmintics
Anti-Infective Agents
Antinematodal Agents
Antiparasitic Agents
Antiparasitic Products, Insecticides and Repellents
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
