PRL

PROFLAVIN

Created:	1999-07-08
Last modified:	2011-06-04

Find Related PDB Entry
11 entries where PRL is found as a standalone ligand

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	27
Chiral Atom Count	0
Bond Count	29
Aromatic Bond Count	16

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	PROFLAVIN
Systematic Name (OpenEye OEToolkits)	acridine-3,6-diamine
Formula	C₁₃ H₁₁ N₃
Molecular Weight	209.247
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	n1c3c(cc2c1cc(N)cc2)ccc(c3)N
SMILES	CACTVS	3.341	Nc1ccc2cc3ccc(N)cc3nc2c1
SMILES	OpenEye OEToolkits	1.5.0	c1cc(cc2c1cc3ccc(cc3n2)N)N
Canonical SMILES	CACTVS	3.341	Nc1ccc2cc3ccc(N)cc3nc2c1
Canonical SMILES	OpenEye OEToolkits	1.5.0	c1cc(cc2c1cc3ccc(cc3n2)N)N
InChI	InChI	1.03	InChI=1S/C13H11N3/c14-10-3-1-8-5-9-2-4-11(15)7-13(9)16-12(8)6-10/h1-7H,14-15H2
InChIKey	InChI	1.03	WDVSHHCDHLJJJR-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB01123
Name	Proflavine
Groups	approved
Description	3,6-Diaminoacridine. Topical antiseptic used mainly in wound dressings.
Synonyms	3,6-diaminoacridine Proflavine Diaminoacridine Proflavin Proflavinum 2,8-Diaminoacridine 3,6-acridinediamine Proflavine hemisulfate Proflavina
Brand Names	Triple Dye Kerr 100 Triple Dye Dispos-A Perineze Triple Dye
Indication	Topical antiseptic used mainly in wound dressings.
Categories	Acridines Aminoacridines Anti-Infective Agents Anti-Infective Agents, Local Heterocyclic Compounds, Fused-Ring
CAS number	92-62-6

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
DNA	-	unknown	intercalation
Prothrombin	MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEE...	unknown	other/unknown
HTH-type transcriptional regulator QacR	MNLKDKILGVAKELFIKNGYNATTTGEIVKLSESSKGNLYYHFKTKENLF...	unknown
TetR family transcriptional repressor LfrR	MTSPSIESGARERTRRAILDAAMLVLADHPTAALGDIAAAAGVGRSTVHR...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682