Pidolic acid is a naturally occurring but little-studied amino acid derivative that can be formed enzymatically or non-enzymatically and participates as a biological intermediate with unique pharmacodynamics in various chemical pathways [A32991, L2729]. Elevations of the acid in blood levels may be associated with problems of glutamine or glutathione metabolism [L2729]. Pidolic acid, in general, is found in large quantities in brain tissue and other tissues in bound form, like skin [L2729]. There are currently little to no medicines available that are clinically approved or marketed for employing pidolic acid as an active ingredient for any particular formal indication. Although pidolic acid is included in some over-the-counter, non-prescription dietary supplements for the proposed purpose of facilitating cognitive or memory enhancement, most available research suggest exercising caution in their recommendation as much more research is necessary [A32981, A32982].
Synonyms
Zinc pidolate
(S)-(−)-2-pyrrolidone-5-carboxylic acid
5-oxo-2-pyrrolidinecarboxylic acid
Pidolic acid
Glutimic acid
Sodium pidolate
PCA
5-oxo-L-proline
Magnesium pidolate
(−)-2-pyrrolidone-5-carboxylic acid
5-L-oxoproline
(S)-pyroglutamic acid
L-5-Pyrrolidone-2-carboxylic acid
5-Pyrrolidone-2-carboxylic acid
L-pyroglutamic acid
L-pyrrolidone carboxylic acid
Pyroglutamic acid
Brand Names
2% Salicylic Acid FACIAL CLEANSER
Lacticare Lot
Cleansing Foaming Gel Acne Pro Skin
Mag 2 Pwr 1.5gm/pck
Indication
There is currently no clinically approved and/or marketed medicine that relies upon pidolic acid as an active ingredient for any formal therapeutic indication. Although pidolic acid may be sold in a variety of non-prescription, over-the-counter dietary supplement products for cognitive or memory enhancement, there are many studies that suggest that such products or such supplementation do not elicit any kind of cognitive benefit to users [A32981, A32982]. In fact, the general suggestion for any such pidolic acid product is to exercise caution in their recommendation as much more research is necessary [A32981]. Pidolic acid and sodium pidolic acid are, however, used to some extent in skin and hair conditioning agents owing to their humectant characteristics [F53].
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
