Atropine is an alkaloid originally synthesized from Atropa belladonna. It is a racemic mixture of d-and l-hyoscyamine, of which only l-hyoscyamine is pharmacologically active.[A251670,L42835] Atropine is generally available as a sulfate salt and can be administered by intravenous, subcutaneous, intramuscular, intraosseous, endotracheal and ophthalmic methods. Oral atropine is only available in combination products.[A251660,L42840] Atropine is a competitive, reversible antagonist of muscarinic receptors that blocks the effects of acetylcholine and other choline esters.[A251660,L42815,L42825,L42835] It has a variety of therapeutic applications, including pupil dilation and the treatment of anticholinergic poisoning and symptomatic bradycardia in the absence of reversible causes.[A251660] Atropine is a relatively inexpensive drug and is included in the World Health Organization List of Essential Medicines.[A251675]
Synonyms
(±)-hyoscyamine
dl-tropyltropate
Atropin
(±)-atropine
Atropine
Tropine tropate
Atropine sulfate anhydrous
Atropinum
dl-Hyoscyamine
Atropine sulfate
Atropine hydrochloride
Atropina
Brand Names
Quadrapax
PB Hyos
Belladonna Alkaloids with Phenobartbital
Diban Cap
Re-PB Hyos
Atropine Injection Bp 0.6mg/ml
Phenobarbital with Belladonna Alkaloids - Grape
Donnagel Liq
Motofen
Donnatal Tab
Servira
Atropisol
Diphenoxylate hydrochloride and atropine sulfate
Atropine Sulfate Inj 0.4mg/0.5ml
DuoDote
Alcon Atropine
Atropine Sulfate Inj 0.4mg/ml
Atropine Care
Atropine Sulfate
Belladonna Alkaloids with Phenobarbital
Isopto Atropine
Atropine Sulfate Injection USP
Atropine Sulphate 1% - Liq Oph
Atropine Injection BP
Minims Atropine Sulphate
N/a
Odan-atropine
Atropine Sulfate Inj 0.3mg/ml
Diphenoxylate Hydrochloride and Atropine Sulfate
Phenohytro
Enlon-Plus
Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate and Scopolamine Hydrobromide
ATNAA atropine and pralidoxime chloride Auto-Injector
Atropine Sulfate Inj 0.6mg/ml
Atropine Sulfate Inj 1mg/ml
Atropine Sulfate Injection
Phenobarbital with Belladonna Alkaloids
Urised
Diphenoxylate Hcl and Atropine Sulfate
Donnatal Elixir
Atropine Injection Bp 0.4mg/ml
Atropine
Indication
The intravenous, intramuscular, subcutaneous, intraosseous and endotracheal use of atropine is indicated for the temporary blockade of severe or life-threatening muscarinic effects.[L42815,L42835] The intramuscular use of atropine in the form of a pen injector is indicated for the treatment of poisoning by susceptible organophosphorus nerve agents having cholinesterase activity as well as organophosphorus or carbamate insecticides in adult and pediatric patients.[L42825] The ophthalmic use of atropine is indicated for mydriasis, cycloplegia, and penalization of the healthy eye in the treatment of amblyopia.[L42830] In combination with difenoxin or diphenoxylate (tablets for oral use), atropine is indicated as adjunctive therapy in the management of acute nonspecific diarrhea.[L42840,L42865]
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
