NMY

NEOMYCIN

Created:	2007-07-25
Last modified:	2020-06-05

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27 entries where NMY is found as a standalone ligand3 entries where NMY is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	88
Chiral Atom Count	19
Bond Count	91
Aromatic Bond Count	0

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Chemical Component Summary
Name	NEOMYCIN
Synonyms	MYCIFRADIN; NEOMAS; PIMAVECORT; VONAMYCIN
Systematic Name (OpenEye OEToolkits)	(2R,3S,4R,5R,6R)-5-amino-2-(aminomethyl)-6-[(1R,2R,3S,4R,6S)-4,6-diamino-2-[(2S,3R,4S,5R)-4-[(2R,3R,4R,5S,6S)-3-amino-6-(aminomethyl)-4,5-dihydroxy-oxan-2-yl]oxy-3-hydroxy-5-(hydroxymethyl)oxolan-2-yl]oxy-3-hydroxy-cyclohexyl]oxy-oxane-3,4-diol
Formula	C₂₃ H₄₆ N₆ O₁₃
Molecular Weight	614.644
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O(C2C(OC1OC(CN)C(O)C(O)C1N)C(N)CC(N)C2O)C4OC(C(OC3OC(CN)C(O)C(O)C3N)C4O)CO
SMILES	CACTVS	3.341	NC[CH]1O[CH](O[CH]2[CH](N)C[CH](N)[CH](O)[CH]2O[CH]3O[CH](CO)[CH](O[CH]4O[CH](CN)[CH](O)[CH](O)[CH]4N)[CH]3O)[CH](N)[CH](O)[CH]1O
SMILES	OpenEye OEToolkits	1.5.0	C1C(C(C(C(C1N)OC2C(C(C(C(O2)CN)O)O)N)OC3C(C(C(O3)CO)OC4C(C(C(C(O4)CN)O)O)N)O)O)N
Canonical SMILES	CACTVS	3.341	NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)[C@H](N)[C@@H](O)[C@@H]1O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C1[C@H]([C@@H]([C@H]([C@@H]([C@H]1N)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CN)O)O)N)O[C@H]3[C@@H]([C@@H]([C@H](O3)CO)O[C@@H]4[C@@H]([C@H]([C@@H]([C@@H](O4)CN)O)O)N)O)O)N
InChI	InChI	1.03	InChI=1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChIKey	InChI	1.03	PGBHMTALBVVCIT-VCIWKGPPSA-N

Drug Info: DrugBank

DrugBank ID	DB00452
Name	Framycetin
Groups	approved
Description	A component of neomycin that is produced by Streptomyces fradiae. On hydrolysis it yields neamine and neobiosamine B. (From Merck Index, 11th ed)
Synonyms	Framicetina Neomycin B Framycetinum Framycétine Fradiomycin B Framycetin sulfate Framycetin
Brand Names	Teva-proctosone Sofracort Ear/eye Ointment Proctol Ointment Soframycin Eye Drops Proctosedyl Suppositories Soframycin Sterile Eye Ointment 0.5% Soframycin Eye Drops 0.5% Sofracort Proctosedyl Ointment Proctosedyl Sup Sofra-tulle Proctol Suppositories Odan Proctomyxin HC Soframycin Nasal Spray Sofra Tulle 10 X 10cm Sandoz Opticort Odan Proctomyxin HC Suppositories Proctosedyl Soframycin Skin Ointment Sofracort Sterile Ear/eye Ointment Soframycin Ointment Soframycin Sterile Eye Ointment Sofra Tulle Strip (10 X 30cm) Sofracort Eye/ear Drops Soframycin Eye Drops 5mg/ml Soframycin Eye Ont 0.5% Sofracort Sterile Ear/eye Drops
Indication	For the treatment of bacterial blepharitis, bacterial bonjunctivitis, corneal injuries, corneal ulcers and meibomianitis. For the prophylaxis of ocular infections following foreign body removal
Categories	Agents that produce neuromuscular block (indirect) Aminoglycoside Antibacterials Anti-Bacterial Agents Anti-Infective Agents Carbohydrates Dermatologicals Glycosides Medicated Dressings Medicated Dressings With Antiinfectives Nasal Preparations Nephrotoxic agents Ophthalmologicals Sensory Organs
ATC-Code	D09AA01 R01AX08 S01AA07
CAS number	119-04-0

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
16S ribosomal RNA	-	unknown	inhibitor
30S ribosomal protein S12	MATVNQLVRKPRARKVAKSNVPALEACPQKRGVCTRVYTTTPKKPNSALR...	unknown	inhibitor
C-X-C chemokine receptor type 4	MEGISIYTSDNYTEEMGSGDYDSMKEPCFREENANFNKIFLPTIYSIIFL...	unknown	antagonist

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682