MGB

METHYLGLYOXAL BIS-(GUANYLHYDRAZONE)

Created:	2001-03-14
Last modified:	2011-06-04

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1 entries where MGB is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	25
Chiral Atom Count	0
Bond Count	24
Aromatic Bond Count	0

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Chemical Component Summary
Name	METHYLGLYOXAL BIS-(GUANYLHYDRAZONE)
Systematic Name (OpenEye OEToolkits)	1-[2-(carbamimidoylhydrazinylidene)propylideneamino]guanidine
Formula	C₅ H₁₂ N₈
Molecular Weight	184.202
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	N(/NC(=[N@H])N)=C\C(=N\NC(=[N@H])N)C
SMILES	CACTVS	3.341	CC(C=NNC(N)=N)=NNC(N)=N
SMILES	OpenEye OEToolkits	1.5.0	[H]N=C(N)NN=CC(=NNC(=N)N)C
Canonical SMILES	CACTVS	3.341	CC(/C=N/NC(N)=N)=N\NC(N)=N
Canonical SMILES	OpenEye OEToolkits	1.5.0	[H]/N=C(\N)/N/N=C/C(=NNC(=N)N)C
InChI	InChI	1.03	InChI=1S/C5H12N8/c1-3(11-13-5(8)9)2-10-12-4(6)7/h2H,1H3,(H4,6,7,12)(H4,8,9,13)/b10-2+,11-3+
InChIKey	InChI	1.03	MXWHMTNPTTVWDM-NXOFHUPFSA-N

Drug Info: DrugBank

DrugBank ID	DB12967
Name	Mitoguazone
Groups	investigational
Description	Mitoguazone has been used in trials studying the treatment of Lymphoma, HIV Infections, and Lymphoma, Non-Hodgkin.
Synonyms	Mitoguazone dihydrochloride Mitoguazona Mitoguazone Methyl-G Mitoguazonum Me-GAG
Categories	Amidines Antineoplastic Agents Antineoplastic and Immunomodulating Agents Enzyme Inhibitors Guanidines
ATC-Code	L01XX16
CAS number	459-86-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
S-adenosylmethionine decarboxylase proenzyme	MEAAHFFEGTEKLLEVWFSRQQPDANQGSGDLRTIPRSEWDILLKDVQCS...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682