M6P

6-O-phosphono-alpha-D-mannopyranose

Created:	1999-07-08
Last modified:	2020-07-17

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14 entries where M6P is found as a standalone ligand2 entries where M6P is found in a branched oligosaccharide

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Chemical Details
Formal Charge	0
Atom Count	29
Chiral Atom Count	5
Bond Count	29
Aromatic Bond Count	0

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Chemical Component Summary
Name	6-O-phosphono-alpha-D-mannopyranose
Synonyms	ALPHA-D-MANNOSE-6-PHOSPHATE; 6-O-phosphono-alpha-D-mannose; 6-O-phosphono-D-mannose; 6-O-phosphono-mannose
Systematic Name (OpenEye OEToolkits)	[(2R,3S,4S,5S,6S)-3,4,5,6-tetrahydroxyoxan-2-yl]methyl dihydrogen phosphate
Formula	C₆ H₁₃ O₉ P
Molecular Weight	260.136
Type	D-SACCHARIDE, ALPHA LINKING

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=P(O)(O)OCC1OC(O)C(O)C(O)C1O
SMILES	CACTVS	3.341	O[CH]1O[CH](CO[P](O)(O)=O)[CH](O)[CH](O)[CH]1O
SMILES	OpenEye OEToolkits	1.5.0	C(C1C(C(C(C(O1)O)O)O)O)OP(=O)(O)O
Canonical SMILES	CACTVS	3.341	O[C@H]1O[C@H](CO[P](O)(O)=O)[C@@H](O)[C@H](O)[C@@H]1O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C([C@@H]1[C@H]([C@@H]([C@@H]([C@H](O1)O)O)O)O)OP(=O)(O)O
InChI	InChI	1.03	InChI=1S/C6H13O9P/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8/h2-10H,1H2,(H2,11,12,13)/t2-,3-,4+,5+,6+/m1/s1
InChIKey	InChI	1.03	NBSCHQHZLSJFNQ-PQMKYFCFSA-N

Drug Info: DrugBank

DrugBank ID	DB02900
Name	alpha-D-mannose 6-phosphate
Groups	experimental
Synonyms	(6P)Manα alpha-D-Mannopyranose 6-phosphate Man6P 6-O-phosphono-α-D-mannopyranose (6P)Mana alpha-D-mannose 6-phosphate α-D-mannose 6-phosphate 6-H2PO3Manα
CAS number	40436-60-0

Drug Targets

Name	Target Sequence	Pharmacological Action
Phosphomannomutase/phosphoglucomutase	MSTAKAPTLPASIFRAYDIRGVVGDTLTAETAYWIGRAIGSESLARGEPC...	unknown
Cation-independent mannose-6-phosphate receptor	MGAAAGRSPHLGPAPARRPQRSLLLLQLLLLVAAPGSTQAQAAPFPELCS...	unknown
Cation-dependent mannose-6-phosphate receptor	MFPFYSCWRTGLLLLLLAVAVRESWQTEEKTCDLVGEKGKESEKELALVK...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682