HQE

benzene-1,4-diol

Created:	2012-03-14
Last modified:	2024-09-27

Find Related PDB Entry
7 entries where HQE is found as a standalone ligand4 entries where HQE is covalently linked to polymer or other heterogen groups

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	14
Chiral Atom Count	0
Bond Count	14
Aromatic Bond Count	6

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	benzene-1,4-diol
Systematic Name (OpenEye OEToolkits)	benzene-1,4-diol
Formula	C₆ H₆ O₂
Molecular Weight	110.111
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	12.01	Oc1ccc(O)cc1
SMILES	CACTVS	3.370	Oc1ccc(O)cc1
SMILES	OpenEye OEToolkits	1.7.6	c1cc(ccc1O)O
Canonical SMILES	CACTVS	3.370	Oc1ccc(O)cc1
Canonical SMILES	OpenEye OEToolkits	1.7.6	c1cc(ccc1O)O
InChI	InChI	1.03	InChI=1S/C6H6O2/c7-5-1-2-6(8)4-3-5/h1-4,7-8H
InChIKey	InChI	1.03	QIGBRXMKCJKVMJ-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB09526
Name	Hydroquinone
Groups	approved investigational
Description	Hydroquinone is a topical lightening product found in OTC products, and is used to correct skin discoloration associated with disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots, and freckles. It can be used alone, but is more frequently found in combination with other agents such as alpha-hydroxy acids, corticosteroids, retinoids, or sunscreen. Hydroquinone has come under scrutiny due to several complications associated with its use, including dermal irritation, exogenous onchronosis, and carginogenicity. As a result of these concerns, hydroquinone has been banned in the EU and UK.
Synonyms	p-hydroxyphenol 4-Hydroxyphenol p-Hydroquinone benzene-1,4-diol p-Benzenediol Hydroquinone 1,4-benzenediol Quinol 1,4-dihydroxybenzene
Brand Names	Esoterica Scented-fortified With Sunscreen NU-DERM System NORMAL-Oily SKIN TRANSFORMATION Crusader Skin Lightening Restoration Serum Epione REVERSE Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots 141067 Hydroquinone 8% Porcelana Night Skin Lightening Porcelana 24 Hour Skin Lightening MELAMIN Skin Bleaching and Correcting Hydroquinone Nadinola Skin Disc.fade Crm for Oily Skin 2% SH18 Skin Lightening Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.05% Palmer's Skin Success Fade Cream-normal Skin Glytone Clarifying I-max Lightening L Crusader Ultra Skin Lightening NU-DERM system NORMAL-oily SKIN TRANSFORMATION TRIAL OBAGI C RX system C CLARIFYING SERUM Lustra AGELESS Total Skin Bleaching Serum African Formula Carrot Hydroquinone Obagi-C Rx System Normal-dry Skin Intervention Topiclear Paris Multi Complex Fade Neostrata Canada Hq Plus Cream Clear-N-Smooth PLUS Porcelana Medicated Fade Cream - Orig. Fmla Porcelana Day Skin Lightening Olivia Quido Blemish Eraser Hydroquinone 8% Movate Skin Lightening Lemon Pure Valley Miracle Age Spot Hydroquinone 8%. Clear-N-Smooth Idole Beauty Viquin Forte With Moisturizing Aha - Crm REVERS Lightening Regimen for the Appearance of Stubborn Dark Marks, Patches and Age Spots Travel Size Topiclear Xtra beauty Hydro-Q Obagi Protocols Clear Advanced Lightning Hydroquinone 6% /tretinoin 0.05% Dr. Throwers Skin Lightening Moisturizing Lightener Ultra Glow Skin Tone Cream Oily Skin Aloe Vera Drula Fade Cream Medium-medicated Phaze 13 Light N' Block Pigment Cream Skinprint 3D Clear Peel NeoStrata HQ Skin Lightening Sunvanish Gold Cosmetics Adi Clear ZO Skin Health Pigment Control Creme Hydroquinone Glytone SunVanish Skin Lightening Corrector Light eB5 Age Sport Formula Hyaluronic Acid Sodium Salt 1% / Hydroquinone 6% Hydrocortisone 2.5% / Hydroquinone 4% / Tretinoin 0.025%, Eldoquin Forte Pigment Clear-N-Smooth Super-Ultimate Pharmaskincare Parfait Lightening Serum Hydroquinone 6% / Tretinoin 0.05% / Triamcinolone 0.025% NEXT GENERATION Correct Brightening Serum Solaquin Forte Nadinola Skin Discoloration Fade Cream-S.C.f Ambi Skincare Normal Skin Fade Clear Essence Skin Lightening Gel Topiclear Lemon Nadinola Skin Fade for Oily Skin Skin Lightening Rodan Fields Accelerated Dark Spot Corrector Top White BEST Age Spot Remover Idole Skin Lightening Solaquin Light The Way EpiQuin Micro gloTriple Action Serum Ultraplus Skin Lightening Cream - 2% Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Sunbalance Teatrical Pro-Aclarant Skin Lightening Artra Skin Tone for Dry Skin Dermaclair Skin Lightening OBAGI-C RX system NORMAL-oily SKIN INTERVENTION Esoterica Nighttime with Moisturizers Glyquin Xm Banishing Cream Continuum Unifying Lotion I Obagi Nu-Derm 141017 Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Cicatricure Skin Lightening Hyperpigmentation Treatment Obagi-C Rx System Normal-oily Skin Intervention Scarlight MD Ultraquin 4% Hydroquinone Cream With Sunscreens Corrector 2 Ambi Fade Normal Skin OLIVIA QUIDO FIRM and FADE I Esoterica Facial Cream NeoCeuticals Post Acne Fade ZO MEDICAL MELAMIN-C Skin Bleaching and Correcting with Vitamin C Hydroquinone Double White Lightening HQ Spot African Formula Skin Lightening Topiclear Dermablend Chromatone Fade Cream With Sunscreen Hyaluronic Acid Sodium Salt 0.5% / Hydroquinone 4% / Tretinoin 0.05% Black and White Skin Bleach Gold Cosmetics Bleach Cream Caro Light Creme Blanchissante - Crm 2% Hydroquinone Skin Bleaching Agent Normal Skin Seequin 4 Ids Fade Away Extra Care Dermablend Advanced Fade Cream With Sunscreen and Moisturizing Aha Clear Essence Advance Complex Fade Gel Melpaque HP Porcelana Skin Lightening Daytime Protection Desoximetasone 0.05% / Hydroquinone 6% / Tretinoin 0.05% Medicated Fade Creme with Sunscreen Skin Lightening Cream Even Tone Night Treatment Hydroquinone 4% Essential Fade Complex ZO Skin Health Pigment Control plus Brightening Creme Hydroquinone plus Vitamin C Recover Lightening Complex with 4% Hydroquinone Daily Fade Maximum Strength SPF15 Idole Lemon EB5 Age Spot Treatment Seequin 2 HQ Plus Brightening Cream VI Derm Ultra Glow Fade with Aloe Vera Movate Skin Lightening Zo Medical Zo Multi-therapy Hydroquinone System Spotfade Dark Spot Wand Miracle Fade Idole Natural Organic Nu-derm System Normal-oily Skin Transformation Superlightener SYMBA Skin Lightening Advanced Skin Lightening Cream Proactiv Advanced Dark Spot Correcting Serum Seequin 4 African Formula Black Fade Dark Spots Nighttime Treatment Topiclear Skin Lightening Black Opal Advance Dual Complex Fade Gel Skin Lightening Treatment Dolly Intense Lightening Lumipearl Dark Mark Corrector Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation Kit Idole Black Cenovia Image MD Lightening Rx MELAMIN Skin Bleaching and Correcting Alphaquin HP ELASTIDERM DECOLLETAGE SKIN LIGHTENING COMPLEX Chest and Neck Fading Fluid Total White Brightening Dr. Throwers Pbc No. 1 Eldopaque Forte Crm 4% ZO Skin Health Multi-Therapy Hydroquinone System AMBI Skincare Oily Skin Fade ZO Skin Health Pigment Control Program Plus Hydroquinone Olivia Quido Skincare Blemish Eraser Skin Beautifying Milk Dermisa Skin Fade Cream 141060 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% Jouvence Crm 2% 141030 Hydroquinone 8% Condition and Enhance System Travel-size Surgical Hqla Lustra AF NU-DERM BLENDER Skin Lightener and Blending New York Fair and Lovely Corrector 4 Rejuvaderm medispa fading Activator Light Balancer SLMD Skincare by Sandra Lee, M.D. - Dark Spot Fix Ultra Glow Skin Tone Cream for Oily Skin NU-DERM CLEAR Skin Bleaching and Corrector Dark Spot Lightening Cream Dr. Lightening Ultra-Potent Facial Nuquin Hp Alumier MD Lightening Vivant True Tone Continuum Unifying Lotion II Piona Advanced Skin Lightening Serum Drula Fade Cream Extra-medicated Rodan & Fields Proactiv Solution: Skin Lightening Lotion Derma Lightening Unblemish Regimen for Acne and Post Acne Marks 141011 Hydroquinone 6% Differin Dark Spot Correcting Serum Body Fade Creme Maximum Strength Nadinola Skin Fade for Dry Skin Topiclear Paris Beauty Perrigo Hydroquinone with sunscreens Conditioning Gel CONDITION AND ENHANCE CLEAR Skin Bleaching and Corrector Clairissime Clear Complexion Lotion SH18 Caviar Beauty Topiclear Carrot Body Merry Lightening and Whitening Cream Ambi Fade Oily Skin Nu-derm System Normal-dry Skin Transformation Trial Obagi Medical - Nu-Derm System - Normal to Dry - Skin Transformation Trial Kit I-max Lightening 5 Vivant True Tone Forte Ultra-Potent Brightening Serum 141016 Hydrocortisone 0.5% / Hydroquinone 4% / Tretinoin 0.025% 141010 Hydroquinone 4% Othine Skin Bleach Vantex Skin Bleaching Crm W Sunscreen 2% Obagi Nu-Derm Sunfader Meaningful Beauty Dark Spot Correcting Treatment Skin Lightener Triderma Hydroquinone 6% Hydrocortisone 1% / Hydroquinone 8% / Tretinoin 0.05% Active 4 Hydrocortisone 0.5% / Hydroquinone 6% Advanced Dual Complex Fade Maximum Strength Plus Dual Action Skin Lightener CONDITION AND ENHANCE BLENDER Skin Lightener and Blending Esoterica Unscented Fortified W.sun Screen Glytone Clarifying SunVanish with Sunscreen Hydroquinone cream Palmer's Skin Success Fade Cream-for Oily Sk Nadinola Skin FadeExtra Nu-derm Travel Set Normal/dry Skin Transformation System 141055 Hydroquinone 6% Ultra Glow Skin Tone Cream Normal Skin Aloe Vera Glytone Skin Lightening Nova Complex HQ Ultra Glow Fade AMBI Fade Oily Skin OBAGI-C Rx system C-CLARIFYING SERUM NORMAL TO oily SKIN LIGHTENING SERUM WITH VITAMIN C Black Opal Advanced Dual Phase Fade Creme Ultra Glow Skin Tone Cream for Normal Skin Obagi-C Rx system C-Therapy Night Skin Lightening with Vitamins C and E Exence White Artra Skin Tone for Normal Skin Fair and White Hydroquinone with sunscreens 141061 Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Clarite 4 Neostrata Hq Plus Lightening Cream Nu-derm System Normal-oily Skin Transformation Trial Proactiv Skin Lightening Ambi Extra Skin Discoloration Fade Cream Pa Plus Advanced Dark Spot Correcting Serum Top White Skin Lightening Glytone Dark Spot Corrector Esoterica Daytime with Sunscreen Artra Skin Tone for Oily Skin Hydroquinone Skin Bleaching Agent Oily Skin Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.05% Obagi Celazome Fade Shades Lightening Cream w/ Glycolic Acid Enlighten Me Topiclear Xtra lemon beauty Gold Cosmetics Bleach Cream Silver Unblemish Precious Beauty Skin Lightening Vividly Brilliant Perfecting Esoterica Daytime with Moisturizers and Sunscreen Fade Dark Spots Daytime Treatment Brighten Lightening Exuviance Intense Lightening Complex PLEXADERM Dark Spot Fade Gel Sh18 Unblemish Dermatologist Developed Spot Fading Toner Aclaro PD Hydroquinone Erfa Hydroquinone Topiclear Cocoa Butter Meditowel Illuminating Skin Brightening NU-DERM SUNFADER Skin Lightener with Sunscreen (SPF 15) PABA FREE Obagi - C Hydroquinone 5% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025% African Gold Skin Discoloration Fade Crm 2% Tri-luma Metasol Skin Lightening Complex Clear-N-Smooth SuperMax Esoterica Unscented Nu-derm Starter Set Normal-dry Skin Transformation System Porcelana Medicated Fade Crm Sunscreen Fmla Melquin 3 Nuderm Sunfader Sledgehammer Esoterica Sunscreen Fade Cream Condition and Enhance System Full-size Non-surgical Topiclear Cocoa Butter beauty Glytone skin bleaching fading Hydrocortisone 0.5% / Hydroquinone 8% / Tretinoin 0.025% Palmer's Skin Success Fade Cream-for Dry Skn Pharmaskincare Serum Skin Lightening Dermisa Skin Fade Nu-derm Starter Set Normal-oily Skin Transformation System Nadinola Skin Fade for Normal Skin Idole Intense Epiquin Micro Drula Fade Cream Normal-medicated Movate Lemon Dermisa Skin Fade Vitamin C infused Hydrocortisone 0.5% / Hydroquinone 6% / Tretinoin 0.025% Gold Cosmetics Bleach Cream Forte Condition and Enhance System Travel-size Non-surgical Skinprint ClearTone with 8% Hydroquinone Nu-derm System Normal-dry Skin Transformation Hydroquinone 4% / Tretinoin 0.025% / Triamcinolone Acetonide 0.025% PCA Skin Intensive Pigment Eraser OBAGI-C RX System NORMAL-DRY SKIN INTERVENTION Melquin Hp Nadinola Skin Disc.fade Crm for Dry Skin 2% LumaSilk Emulsion Level 03 Porcelana Skin Lightening Nighttime Hydration Hydroquinone Time Release Lustra-AF Skinprint Recover Lightening Complex with 2% Hydroquinone Esoterica Regular Cream LumaSilk Emulsion Level 02 Idole Carrot NU-DERM system NORMAL-DRY SKIN TRANSFORMATION TRIAL Proactiv Solution Dark Spot Corrector Bright Malika and Khadija Brightening Spot Treatment MD Acne Medicated Dark Spot Remover Teatrical Skin Lightening Skin Lightener Eldoquin Clear Essence Skin Lightening Milk eB5 Age Spot Formula Movate Carrot Borba Age Defying Skin Lightening Spot Treatment Clear-N-Smooth Ultimate Hqra-otc Divine Derrier Skin Bleaching cream Ultra Glow Skin Tone Cream Dry Skin Aloe Vera Metasol Skin Lightening Neova Complex HQ Plus Hydroquinone 4% / Tretinoin 0.025% Rodan and Fields Skin Lightening Treatment Eldopaque Crm 2% SH 18 Whitening ZO Skin Health Pigment Control Plus Blending Creme Hydroquinone Skinprint ClearTone with 2% Hydroquinone AMBI Fade Normal Skin Medisilke Night Clear Essence Medicated Fade Cream Skin Lightening Accelerator Pack Aclaro Hydroquinone MELAMIX Skin Lightener and Blending SH18 Ultra Harmonie Carrot Beauty Zarina Skin Lightening Cream With Sunscreening Filter Clear-N-Smooth UltraMax Hydroquinone 8% / Tretinoin 0.025% Idole Natural Organic Skin Lightening Drula Fade Cream Superforte Medicated Hydroquinone 8% / Tretinoin 0.025%. Hot Movate Clear Action OLIVIA QUIDO FIRM and FADE II
Indication	Hydroquinone is used as an OTC topical lightening agent for disorders of hyperpigmentation including melasma, post-inflammatory hyperpigmention, sunspots and freckles.
Categories	Antioxidants Benzene Derivatives Biological Factors Compounds used in a research, industrial, or household setting Depigmenting Agents Dermatologicals Melanin Synthesis Inhibitor Melanin Synthesis Inhibitors Mutagens Noxae Phenols Protective Agents Radiation-Protective Agents Toxic Actions
ATC-Code	D11AX11
CAS number	123-31-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Tyrosinase	MLLAVLYCLLWSFQTSAGHFPRACVSSKNLMEKECCPPWSGDRSPCGQLS...	unknown	inhibitor
Cysteinyl leukotriene receptor 1	MDETGNLTVSSATCHDTIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLIK...	unknown	activator
Lysosomal alpha-glucosidase	MGVRHPPCSHRLLAVCALVSLATAALLGHILLHDFLLVPRELSGSSPVLE...	unknown	product of
Serum albumin	MKWVTFISLLFLFSSAYSRGVFRRDAHKSEVAHRFKDLGEENFKALVLIA...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682

Related Resource References

Resource Name	Reference
Pharos	CHEMBL537
PubChem	785
ChEMBL	CHEMBL537
ChEBI	CHEBI:17594
CCDC/CSD	BATRET, CPFEHQ, CIRWEG, AXILUQ, EBILUX, BOKHUG, CEFDOG, COHWIF01, CISCOW, CAKZEV, DOMBEN, BIRQUO, EDAYUG, COZZIB, EDAYEQ, BAVKOA, CABWAD, COHWIF03, ABORAM, COZZOH, BAMZUN01, ACESIL, BAMZUN, AVEKER, EBIMEI, COHWIF02, BUSPAG, BZMETD, EKESIY04, EKESIY05, DIZCEV, DAMPOZ, DAMPOZ01, EKESIY01, EKESIY02, BAMZUN02, EKESIY03, EKESIY06, EKESAQ02, EKESAQ01, ABOQUF, BACRAB, CIPLES, CARWUP, BAMZUN03, COHWIF, CARWUP02, CARWUP01, AVEKIY
COD	2100714, 2100715, 2100716, 2100717, 2211791, 2103388, 2204577, 2100228, 2100231