HAE

ACETOHYDROXAMIC ACID

Created:	1999-07-08
Last modified:	2024-09-27

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24 entries where HAE is found as a standalone ligand5 entries where HAE is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	10
Chiral Atom Count	0
Bond Count	9
Aromatic Bond Count	0

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Chemical Component Summary
Name	ACETOHYDROXAMIC ACID
Systematic Name (OpenEye OEToolkits)	N-hydroxyethanamide
Formula	C₂ H₅ N O₂
Molecular Weight	75.067
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(NO)C
SMILES	CACTVS	3.341	CC(=O)NO
SMILES	OpenEye OEToolkits	1.5.0	CC(=O)NO
Canonical SMILES	CACTVS	3.341	CC(=O)NO
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC(=O)NO
InChI	InChI	1.03	InChI=1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
InChIKey	InChI	1.03	RRUDCFGSUDOHDG-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00551
Name	Acetohydroxamic acid
Groups	approved
Description	Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Synonyms	Acetyl hydroxyamino Acetohydroximic acid Cetohyroxamic acid Acido acetohidroxamico AHA Acetohydroxamate Acidum acetohydroxamicum Acethydroxamsaeure Methylhydroxamic acid N-Acetyl hydroxyacetamide Acetylhydroxamic acid Acetohydroxamic acid Acetic acid, oxime N-Hydroxyacetamide N-Acetylhydroxylamine Acide acetohydroxamique
Brand Names	Lithostat
Indication	Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Categories	Amines Enzyme Inhibitors Genito Urinary System and Sex Hormones Hydroxy Acids Hydroxylamines Urease Inhibitor Urease Inhibitors Urologicals
ATC-Code	G04BX03
CAS number	546-88-3

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Urease subunit alpha	MSNISRQAYADMFGPTVGDKVRLADTELWIEVEDDLTTYGEEVKFGGGKV...	unknown	inhibitor
Macrophage metalloelastase	MKFLLILLLQATASGALPLNSSTSLEKNNVLFGERYLEKFYGLEINKLPV...	unknown	inhibitor

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682