Eugenol is a naturally occurring phenolic molecule found in several plants such as cinnamon, clove, and bay leaves. It has been used as a topical antiseptic as a counter-irritant and in dental preparations with zinc oxide for root canal sealing and pain control. Although not currently available in any FDA-approved products (including OTC), eugenol has been found to have anti-inflammatory, neuroprotective, antipyretic, antioxidant, antifungal and analgesic properties. Its exact mechanism of action is unknown, however, it has been shown to interfere with action potential conduction. There are a number of unapproved OTC products available containing eugenol that advertise its use for the treatment of toothache.
Synonyms
Eugenol
Brand Names
DenTek Eugenol
TotalArthritis
AnaDent Childrens Kanka Gel
Jiffy Toothache Drops
Walgreens Natural Eugenol/Toothache Medication with cotton pellets and tweezers
Total Arthritis
Eugenol
Red Cross Toothache
Dry Socket Paste
Zonalin Liquid
Nuby Teething Gel
Orajel Naturals FAst Relief for Teething Pain
Baby Orajel Naturals Remedy for Teething Pain Relief
Eugenol Toothache Medication
PainONil
Anti Paronychia Relief
Marshall Toothache Drops
T.R.U.E. Test Thin-Layer Rapid Use Patch Test
Dry Socket
Indication
Eugenol is not currently available in any FDA-approved drug products. There are a number of unapproved OTC products that advertise it for the use of toothache. Eugenol is is also commonly used in combination with zinc oxide in dental procedures for the cementation of temporary prostheses and the temporary restoration of teeth and cavities.
Categories
Acids, Carbocyclic
Alkenes
Allyl Compounds
Allylbenzene Derivatives
Anti-Infective Agents
Benzene Derivatives
Caffeic Acids
Cell-mediated Immunity
Cinnamates
Compounds used in a research, industrial, or household setting
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
