CTC

7-CHLOROTETRACYCLINE

Created: 1999-07-08
Last modified:  2011-06-04

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Chemical Details

Formal Charge0
Atom Count56
Chiral Atom Count5
Bond Count59
Aromatic Bond Count6
2D diagram of CTC
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Chemical Component Summary

Name7-CHLOROTETRACYCLINE
Systematic Name (OpenEye OEToolkits)(4S,4aS,5aS,6S,12aS)-7-chloro-4-dimethylamino-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-4,4a,5,5a-tetrahydrotetracene-2-carboxamide
FormulaC22 H23 Cl N2 O8
Molecular Weight478.88
TypeNON-POLYMER

Chemical Descriptors

TypeProgram Version Descriptor
SMILESACDLabs10.04Clc1c4c(c(O)cc1)C(=O)C3=C(O)C2(O)C(=O)C(=C(O)C(N(C)C)C2CC3C4(O)C)C(=O)N
SMILESCACTVS3.341CN(C)[CH]1[CH]2C[CH]3C(=C(O)[C]2(O)C(=O)C(=C1O)C(N)=O)C(=O)c4c(O)ccc(Cl)c4[C]3(C)O
SMILESOpenEye OEToolkits1.5.0CC1(c2c(ccc(c2C(=O)C3=C(C4(C(CC31)C(C(=C(C4=O)C(=O)N)O)N(C)C)O)O)O)Cl)O
Canonical SMILESCACTVS3.341 CN(C)[C@H]1[C@@H]2C[C@H]3C(=C(O)[C@]2(O)C(=O)C(=C1O)C(N)=O)C(=O)c4c(O)ccc(Cl)c4[C@@]3(C)O
Canonical SMILESOpenEye OEToolkits1.5.0 C[C@]1(c2c(ccc(c2C(=O)C3=C([C@]4([C@@H](C[C@@H]31)[C@@H](C(=C(C4=O)C(=O)N)O)N(C)C)O)O)O)Cl)O
InChIInChI1.03 InChI=1S/C22H23ClN2O8/c1-21(32)7-6-8-15(25(2)3)17(28)13(20(24)31)19(30)22(8,33)18(29)11(7)16(27)12-10(26)5-4-9(23)14(12)21/h4-5,7-8,15,26,28-29,32-33H,6H2,1-3H3,(H2,24,31)/t7-,8-,15-,21-,22-/m0/s1
InChIKeyInChI1.03 CYDMQBQPVICBEU-XRNKAMNCSA-N

Drug Info: DrugBank

DrugBank IDDB09093 
NameChlortetracycline
Groups
  • approved
  • vet_approved
  • investigational
DescriptionChlortetracycline is a _tetracycline_ antibiotic, and historically the first member of this class to be identified. It was discovered in 1945 by the scientist, Benjamin Minge Duggar, working at Lederle Laboratories under the supervision of Yellapragada Subbarow. He discovered that this antibiotic was the product of an actinomycete strain he cultured and obtained from a soil sample from a field in Missouri. The organism was named _Streptomyces aureofaciens_ due to its gold-hued color.
Synonyms
  • Clortetraciclina
  • Chlortétracycline
  • Chlortetracyclinum
  • Chlortetracycline bisulfate
  • Chlortetracycline
Brand Names
  • Aureomycin Ont Oph 1%
  • Aureomycin Ont 3%
  • Aureomycin - Ont Top 3%
IndicationUsed in the manufacuring of medicated animal feeds [FDA Label].
Categories
  • Agents that produce neuromuscular block (indirect)
  • Alimentary Tract and Metabolism
  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antibacterials for Systemic Use
ATC-Code
  • D06AA02
  • S01AA02
  • J01AA03
  • J01AA20
  • A01AB21
CAS number57-62-5

Drug Targets

NameTarget SequencePharmacological ActionActions
16S ribosomal RNA-unknowninhibitor
30S ribosomal protein S3MGQKVHPNGIRLGIVKPWNSTWFANTKEFADNLDSDFKVRQYLTKELAKA...unknowninhibitor
30S ribosomal protein S8MSMQDPIADMLTRIRNGQAANKAAVTMPSSKLKVAIANVLKEEGFIEDFK...unknowninhibitor
30S ribosomal protein S19MPRSLKKGPFIDLHLLKKVEKAVESGDKKPLRTWSRRSTIFPNMIGLTIA...unknowninhibitor
30S ribosomal protein S14MAKQSMKAREVKRVALADKYFAKRAELKAIISDVNASDEDRWNAVLKLQT...unknowninhibitor
View More
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682