Clonidine is an imidazole derivate that acts as an agonist of alpha-2 adrenoceptors.[A180559] This activity is useful for the treatment of hypertension, severe pain, and ADHD.[L7237,L7240,L7243,L7246] Clonidine was granted FDA approval on 3 September 1974.[L7237]
Synonyms
2,6-Dichloro-N-2-imidazolidinylidenebenzenamine
2-((2,6-Dichlorophenyl)imino)imidazolidine
Clonidine
Clonidinum
Chlofazoline
Clonidine hydrochloride
Clonidina
Clonidin
Brand Names
Nu-clonidine Tab 0.1mg
Clorpres
Clonidine Hci
Catapres-TTS
Clonidine hydrochloride
Clonidine Hydrochloride Extended-Release
Apo-clonidine
Clonidine Transdermal System USP, 0.2 mg/day
Apo-clonidine Tab 0.1mg
Clonidine 0.1
Clonidine Transdermal System USP, 0.1 mg/day
Mar-clonidine
Clonidine HCl Tab 0.2mg
Clonidine hydrochloride extended-release
Catapres Tab 0.1mg
Apo-clonidine Tab 0.2mg
Catapres-TTS-3
Duraclon
Kapvay
Nexiclon
Nu-clonidine Tab 0.2mg
Catapres-TTS-2
Clonidine Hydrochloride
Nexiclon XR
Dixarit Tab 0.025mg
Catapres-TTS-1
Jamp Clonidine
Mint-clonidine
Teva-clonidine
Combipres 0.1/15 Tab
Clonidine
Catapres Tab 0.2mg
Catapres
Clonidine Transdermal System USP, 0.3 mg/day
Clonidine transdermal system
Dom-clonidine
Clonidine HYDROCHLORIDE
Ntp-clonidine
Sandoz Clonidine
Indication
Clonidine tablets and transdermal systems are indicated for the treatment of hypertension alone or in combination with other medications.[L7237,L7240] A clonidine injection is indicated for use with opiates in the treatment of severe cancer pain where opiates alone are insufficient.[L7243] An extended release tablet of clonidine is indicated for the treatment of ADHD either alone or in combination with other medications.[L7246] Clonidine is also used for the diagnosis of pheochromocytoma,[A180565] treatment of nicotine dependance,[A180568] and opiate withdrawal.[A180571]
Categories
Adrenergic Agents
Adrenergic Agonists
Adrenergic alpha-1 Receptor Agonists
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-Agonists
Agents producing tachycardia
Agents that produce hypertension
Analgesics
Anesthetics
Anesthetics, General
Antiadrenergic Agents, Centrally Acting
Antiglaucoma Preparations and Miotics
Antihypertensive Agents
Antihypertensive Agents Indicated for Hypertension
Antimigraine Preparations
Autonomic Agents
Bradycardia-Causing Agents
Cardiovascular Agents
Central alpha-2 Adrenergic Agonist
Central Alpha-agonists
Central Nervous System Agents
Central Nervous System Depressants
Cytochrome P-450 CYP1A2 Substrates
Cytochrome P-450 CYP1A2 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP2D6 Substrates
Cytochrome P-450 CYP2D6 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A Substrates
Cytochrome P-450 CYP3A4 Substrates
Cytochrome P-450 CYP3A4 Substrates with a Narrow Therapeutic Index
Cytochrome P-450 CYP3A5 Substrates
Cytochrome P-450 CYP3A5 Substrates with a Narrow Therapeutic Index
Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison
T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS.
Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682
