ANM

ANISOMYCIN

Created:	2001-10-30
Last modified:	2011-06-04

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10 entries where ANM is found as a standalone ligand

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Chemical Details
Formal Charge	0
Atom Count	38
Chiral Atom Count	3
Bond Count	39
Aromatic Bond Count	6

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Chemical Component Summary
Name	ANISOMYCIN
Systematic Name (OpenEye OEToolkits)	[(2R,3S,4S)-4-hydroxy-2-[(4-methoxyphenyl)methyl]pyrrolidin-3-yl] ethanoate
Formula	C₁₄ H₁₉ N O₄
Molecular Weight	265.305
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(OC1C(NCC1O)Cc2ccc(OC)cc2)C
SMILES	CACTVS	3.341	COc1ccc(C[CH]2NC[CH](O)[CH]2OC(C)=O)cc1
SMILES	OpenEye OEToolkits	1.5.0	CC(=O)OC1C(CNC1Cc2ccc(cc2)OC)O
Canonical SMILES	CACTVS	3.341	COc1ccc(C[C@H]2NC[C@H](O)[C@H]2OC(C)=O)cc1
Canonical SMILES	OpenEye OEToolkits	1.5.0	CC(=O)O[C@@H]1[C@H](CN[C@@H]1Cc2ccc(cc2)OC)O
InChI	InChI	1.03	InChI=1S/C14H19NO4/c1-9(16)19-14-12(15-8-13(14)17)7-10-3-5-11(18-2)6-4-10/h3-6,12-15,17H,7-8H2,1-2H3/t12-,13+,14+/m1/s1
InChIKey	InChI	1.03	YKJYKKNCCRKFSL-RDBSUJKOSA-N

Drug Info: DrugBank

DrugBank ID	DB07374
Name	Anisomycin
Groups	experimental
Description	Anisomycin (sometimes known as flagecidin), is an antibiotic retrieved from the bacteria _Streptomyces griseolus_. This drug acts to inhibit bacterial protein and DNA synthesis.
Synonyms	Anisomycin
Categories	Anti-Bacterial Agents Anti-Infective Agents Antiparasitic Agents Antiprotozoals Enzyme Inhibitors Nucleic Acid Synthesis Inhibitors Protein Synthesis Inhibitors Pyrrolidines
CAS number	22862-76-6

Drug Targets

Name	Target Sequence	Pharmacological Action
60S ribosomal protein L10-like	MGRRPARCYRYCKNKPYPKSRFCRGVPDAKIRIFDLGRKKAKVDEFPLGG...	unknown
60S ribosomal protein L13a	MAEVQVLVLDGRGHLLGRLAAIVAKQVLLGRKVVVVRCEGINISGNFYRN...	unknown
60S ribosomal protein L23	MSKRGRGGSSGAKFRISLGLPVGAVINCADNTGAKNLYIISVKGIKGRLN...	unknown
60S ribosomal protein L15	MGAYKYIQELWRKKQSDVMRFLLRVRCWQYRQLSALHRAPRPTRPDKARR...	unknown
60S ribosomal protein L19	MSMLRLQKRLASSVLRCGKKKVWLDPNETNEIANANSRQQIRKLIKDGLI...	unknown
60S ribosomal protein L23a	MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPK...	unknown
Probable ribosome biogenesis protein RLP24	MRIEKCYFCSGPIYPGHGMMFVRNDCKVFRFCKSKCHKNFKKKRNPRKVR...	unknown
60S ribosomal protein L26-like 1	MKFNPFVTSDRSKNRKRHFNAPSHVRRKIMSSPLSKELRQKYNVRSMPIR...	unknown
60S ribosomal protein L8	MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIH...	unknown
60S ribosomal protein L37	MTKGTSSFGKRRNKTHTLCRRCGSKAYHLQKSTCGKCGYPAKRKRKYNWS...	unknown
60S ribosomal protein L3	MSHRKFSAPRHGSLGFLPRKRSSRHRGKVKSFPKDDPSKPVHLTAFLGYK...	unknown
60S ribosomal protein L11	MAQDQGEKENPMRELRIRKLCLNICVGESGDRLTRAAKVLEQLTGQTPVF...	unknown
NHP2-like protein 1	MTEADVNPKAYPLADAHLTKKLLDLVQQSCNYKQLRKGANEATKTLNRGI...	unknown
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Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682