3GC

GAMMA-GLUTAMYLCYSTEINE

Created:	2002-07-01
Last modified:	2024-09-27

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4 entries where 3GC is found as a standalone ligand1 entries where 3GC is covalently linked to polymer or other heterogen groups

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Chemical Details
Formal Charge	0
Atom Count	30
Chiral Atom Count	2
Bond Count	29
Aromatic Bond Count	0

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Chemical Component Summary
Name	GAMMA-GLUTAMYLCYSTEINE
Systematic Name (OpenEye OEToolkits)	(2S)-2-amino-5-[[(2R)-1-hydroxy-1-oxo-3-sulfanyl-propan-2-yl]amino]-5-oxo-pentanoic acid
Formula	C₈ H₁₄ N₂ O₅ S
Molecular Weight	250.272
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=C(O)C(NC(=O)CCC(C(=O)O)N)CS
SMILES	CACTVS	3.341	N[CH](CCC(=O)N[CH](CS)C(O)=O)C(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CC(=O)NC(CS)C(=O)O)C(C(=O)O)N
Canonical SMILES	CACTVS	3.341	N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CC(=O)N[C@@H](CS)C(=O)O)[C@@H](C(=O)O)N
InChI	InChI	1.03	InChI=1S/C8H14N2O5S/c9-4(7(12)13)1-2-6(11)10-5(3-16)8(14)15/h4-5,16H,1-3,9H2,(H,10,11)(H,12,13)(H,14,15)/t4-,5-/m0/s1
InChIKey	InChI	1.03	RITKHVBHSGLULN-WHFBIAKZSA-N

Drug Info: DrugBank

DrugBank ID	DB03408
Name	gamma-Glutamylcysteine
Groups	experimental
Synonyms	L-gamma-glutamyl-L-cysteine γGluCys gamma-Glu-Cys gamma-Glutamylcysteine 5-L-Glutamyl-L-cysteine L-gamma-Glutamylcysteine gamma-L-Glutamyl-L-cysteine Glu(-Cys)
Categories	Amino Acids, Peptides, and Proteins Oligopeptides Peptides
CAS number	636-58-8

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Glutathione synthetase	MATNWGSLLQDKQQLEELARQAVDRALAEGVLLRTSQEPTSSEVVSYAPF...	unknown

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682