210

PAMIDRONATE

Created:	2006-01-11
Last modified:	2020-06-05

Find Related PDB Entry
9 entries where 210 is found as a standalone ligand

Help Find related ligands:
Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Help

Find related ligands:

Similar Ligands (Stereospecific) Similar Ligands (including Stereoisomers) Similar Ligands (Quick Screen) Similar Ligands (Substructure Stereospecific) Similar Ligands (Substructure including Stereoisomers)

Chemical Details
Formal Charge	0
Atom Count	24
Chiral Atom Count	0
Bond Count	23
Aromatic Bond Count	0

Toggle Hydrogen Toggle Labels

Chemical Component Summary
Name	PAMIDRONATE
Synonyms	(3-AMINO-1-HYDROXY-1-PHOSPHONO-PROPYL)PHOSPHONIC ACID
Systematic Name (OpenEye OEToolkits)	(3-amino-1-hydroxy-1-phosphono-propyl)phosphonic acid
Formula	C₃ H₁₁ N O₇ P₂
Molecular Weight	235.069
Type	NON-POLYMER

Chemical Descriptors
Type	Program	Version	Descriptor
SMILES	ACDLabs	10.04	O=P(O)(O)C(O)(CCN)P(=O)(O)O
SMILES	CACTVS	3.341	NCCC(O)([P](O)(O)=O)[P](O)(O)=O
SMILES	OpenEye OEToolkits	1.5.0	C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
Canonical SMILES	CACTVS	3.341	NCCC(O)([P](O)(O)=O)[P](O)(O)=O
Canonical SMILES	OpenEye OEToolkits	1.5.0	C(CN)C(O)(P(=O)(O)O)P(=O)(O)O
InChI	InChI	1.03	InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
InChIKey	InChI	1.03	WRUUGTRCQOWXEG-UHFFFAOYSA-N

Drug Info: DrugBank

DrugBank ID	DB00282
Name	Pamidronic acid
Groups	approved
Description	Pamidronic acid is a second generation, nitrogen containing bisphosphonate similar to [neridronic acid] and [alendronic acid].[A203111] Pamidronic acid was first described in the literature in 1977.[A203267] The second generation bisphosphonates are less common as third generation bisphosphonates, such as [ibandronic acid], [zoledronic acid], [minodronic acid], and [risedronic acid] are becoming more popular.[A203111] Pamidronic acid was granted FDA approval on 31 October 1991.[L13835]
Synonyms	Acido pamidronico Pamidronate Acide pamidronique Acidum pamidronicum Pamidronate Disodium Pamidronic acid
Brand Names	Pamidronate Disodium Omega 6 mg/ml Pamidronate Disodium Aredia 90mg Pamidronate Disodium Omega 3 mg/ml Val-pamidronate Disodium Pamidronate Disodium Omega 9 mg/ml Aredia Liq Inj 3mg/ml Pamidronate Disodium for Injection Aredia PMS-pamidronate Aredia 30mg
Indication	Pamidronate is indicated to treat moderate to severe hypercalcemia of malignancy, moderate to severe Paget's disease of bone, osteolytic bone metastases of breast cancer, and osteolytic lesions of multiple myeloma.[L13838]
Categories	Agents Causing Muscle Toxicity Antineoplastic Agents Bisphosphonates Bone Density Conservation Agents Drugs Affecting Bone Structure and Mineralization Drugs for Treatment of Bone Diseases Musculo-Skeletal System Nephrotoxic agents Organophosphonates Organophosphorus Compounds
ATC-Code	M05BA03
CAS number	40391-99-9

Drug Targets

Name	Target Sequence	Pharmacological Action	Actions
Farnesyl pyrophosphate synthase	MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCW...	unknown	inhibitor
Hydroxylapatite	-	unknown	antagonist
Geranylgeranyl pyrophosphate synthase	MEKTQETVQRILLEPYKYLLQLPGKQVRTKLSQAFNHWLKVPEDKLQIII...	unknown	inhibitor
Caspase-3	MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIII...	unknown	activator
Caspase-9	MDEADRRLLRRCRLRLVEELQVDQLWDALLSRELFRPHMIEDIQRAGSGS...	unknown	activator

Drug Info/Drug Targets: DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS. Nucleic Acids Res. 2011 Jan; 39 (Database issue):D1035-41. | PMID:21059682