9E1H

Structure of RyR1 in the primed state in the presence of oxopyricid

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
B [auth E]SCOP2B SuperfamilyRotamase-like 8098876 3000622 SCOP2B (2022-06-29)
C [auth H]SCOP2B SuperfamilyRotamase-like 8098876 3000622 SCOP2B (2022-06-29)
D [auth G]SCOP2B SuperfamilyRotamase-like 8098876 3000622 SCOP2B (2022-06-29)
E [auth F]SCOP2B SuperfamilyRotamase-like 8098876 3000622 SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A,
F [auth B],
G [auth D],
H [auth C]		PF00622SPRY domain (SPRY)SPRY domainSPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of ...SPRY Domain is named from SPla and the RYanodine Receptor and it is found in many eukaryotic proteins with a wide range of functions. It is a protein-interaction module involved in many important signalling pathways like RNA processing, regulation of histone H3 methylation, innate immunity or embryonic development [1,2,3,4]. It can be divided into 11 subfamilies based on amino acid sequence similarity or the presence of additional protein domains. The greater SPRY family is divided into the SPRY/B30.2 (which contains a PRY extension at the N-terminal) and SPRY-only sub-families which are preceded by a subdomain that is structurally similar to the PRY region [2]. SPRY/B30.2 structures revealed a bent beta-sandwich fold comprised of two beta-sheets. Distant homologues are domains in butyrophilin/ marenostrin/pyrin [1].
Domain
A,
F [auth B],
G [auth D],
H [auth C]		PF08454RyR and IP3R Homology associated (RIH_assoc)RyR and IP3R Homology associated- Repeat
A,
F [auth B],
G [auth D],
H [auth C]		PF02815MIR domain (MIR)MIR domainThe MIR (protein mannosyltransferase, IP3R and RyR) domain is a domain that may have a ligand transferase function [1]. Domain
A,
F [auth B],
G [auth D],
H [auth C]		PF21119Ryanodine receptor junctional solenoid repeat (RYDR_Jsol)Ryanodine receptor junctional solenoid repeat- Repeat
A,
F [auth B],
G [auth D],
H [auth C]		PF01365RIH domain (RYDR_ITPR)RIH domain- Repeat
A,
F [auth B],
G [auth D],
H [auth C]		PF00520Ion transport protein (Ion_trans)Ion transport protein- Family
A,
F [auth B],
G [auth D],
H [auth C]		PF02026RyR domain (RyR)RyR domain- Family
B [auth E],
C [auth H],
D [auth G],
E [auth F]		PF00254FKBP-type peptidyl-prolyl cis-trans isomerase (FKBP_C)FKBP-type peptidyl-prolyl cis-trans isomeraseDomain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A,
F [auth B],
G [auth D],
H [auth C]		Ryanodine receptor 1
B [auth E],
C [auth H],
D [auth G],
E [auth F]		Peptidyl-prolyl cis-trans isomerase FKBP1A

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A,
F [auth B],
G [auth D],
H [auth C]		IPR036300Mir domain superfamilyHomologous Superfamily
A,
F [auth B],
G [auth D],
H [auth C]		IPR000699RIH domainDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR013662RyR/IP3R Homology associated domainDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR016093MIR motifDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR013320Concanavalin A-like lectin/glucanase domain superfamilyHomologous Superfamily
A,
F [auth B],
G [auth D],
H [auth C]		IPR003877SPRY domainDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR001870B30.2/SPRY domainDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR009460Ryanodine Receptor TM 4-6Domain
A,
F [auth B],
G [auth D],
H [auth C]		IPR015925Ryanodine/Inositol 1,4,5-trisphosphate receptorFamily
A,
F [auth B],
G [auth D],
H [auth C]		IPR048581Ryanodine receptor, junctional solenoid domainDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR035910RyR/IP3 receptor binding core, RIH domain superfamilyHomologous Superfamily
A,
F [auth B],
G [auth D],
H [auth C]		IPR003032Ryanodine receptor RyrDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR035761Ryanodine receptor, SPRY domain 1Domain
A,
F [auth B],
G [auth D],
H [auth C]		IPR014821Inositol 1,4,5-trisphosphate/ryanodine receptorDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR035764Ryanodine receptor, SPRY domain 2Domain
A,
F [auth B],
G [auth D],
H [auth C]		IPR013333Ryanodine receptorFamily
A,
F [auth B],
G [auth D],
H [auth C]		IPR043136B30.2/SPRY domain superfamilyHomologous Superfamily
A,
F [auth B],
G [auth D],
H [auth C]		IPR011992EF-hand domain pairHomologous Superfamily
A,
F [auth B],
G [auth D],
H [auth C]		IPR005821Ion transport domainDomain
A,
F [auth B],
G [auth D],
H [auth C]		IPR035762Ryanodine receptor, SPRY domain 3Domain
B [auth E],
C [auth H],
D [auth G],
E [auth F]		IPR046357Peptidyl-prolyl cis-trans isomerase domain superfamilyHomologous Superfamily
B [auth E],
C [auth H],
D [auth G],
E [auth F]		IPR050689FKBP-type Peptidyl-prolyl cis-trans IsomeraseFamily
B [auth E],
C [auth H],
D [auth G],
E [auth F]		IPR001179FKBP-type peptidyl-prolyl cis-trans isomerase domainDomain