9C57 | pdb_00009c57

Reconstituted P400 Subcomplex of the human TIP60 complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
F [auth D]	SCOP2B Superfamily	Nucleic acid-binding proteins	8039200	3000135	SCOP2B (2022-06-29)
G [auth F]	SCOP2B Superfamily	Nucleic acid-binding proteins	8039200	3000135	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Homeodomain-like	8089897	3000001	SCOP2B (2022-06-29)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth E], E [auth C], M [auth A]	PF06068	TIP49 P-loop domain (TIP49)	TIP49 P-loop domain	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) ...	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2].	Domain
A [auth E], E [auth C], M [auth A]	PF17856	TIP49 AAA-lid domain (TIP49_C)	TIP49 AAA-lid domain	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) ...	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2].	Domain
C [auth M], L	PF00022	Actin (Actin)	Actin	-	Family
D [auth B], F [auth D], G [auth F]	PF06068	TIP49 P-loop domain (TIP49)	TIP49 P-loop domain	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) ...	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2].	Domain
D [auth B], F [auth D], G [auth F]	PF17856	TIP49 AAA-lid domain (TIP49_C)	TIP49 AAA-lid domain	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) ...	This family consists of the C-terminal region of several eukaryotic and archaeal RuvB-like 1 (Pontin or TIP49a) and RuvB-like 2 (Reptin or TIP49b) proteins. The N-terminal domain contains the Pfam:PF00004 domain. In zebrafish, the liebeskummer (lik) mutation, causes development of hyperplastic embryonic hearts. lik encodes Reptin, a component of a DNA-stimulated ATPase complex. Beta-catenin and Pontin, a DNA-stimulated ATPase that is often part of complexes with Reptin, are in the same genetic pathways. The Reptin/Pontin ratio serves to regulate heart growth during development, at least in part via the beta-catenin pathway [1]. TBP-interacting protein 49 (TIP49) was originally identified as a TBP-binding protein, and two related proteins are encoded by individual genes, tip49a and b. Although the function of this gene family has not been elucidated, they are supposed to play a critical role in nuclear events because they interact with various kinds of nuclear factors and have DNA helicase activities.TIP49a has been suggested to act as an autoantigen in some patients with autoimmune diseases [2].	Domain
H [auth G]	PF00271	Helicase conserved C-terminal domain (Helicase_C)	Helicase conserved C-terminal domain	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	Domain
H [auth G]	PF00176	SNF2-related domain (SNF2-rel_dom)	SNF2-related domain	This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as w ...	This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1)[1,2,3]. SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilises energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.	Domain
H [auth G]	PF07529	HSA domain (HSA)	HSA domain	-	Family
I	PF16282	SANT/Myb-like domain of DAMP1 (SANT_DAMP1_like)	SANT/Myb-like domain of DAMP1	This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1) that plays an important role in development and maintenace of genome integrity in various mammalia species [2,3]. It mainly consists of ta ...	This domain, approximately 90 residues, is mainly found in DNA methyltransferase 1-associated protein 1 (DAMP1) that plays an important role in development and maintenace of genome integrity in various mammalia species [2,3]. It mainly consists of tandem repeats of three alpha-helices that are arranged in a helix-turn-helix motif and shows a structual similarity with SANT domain and Myb DNA-binding domain, indicating it contains a putative DNA binding site [1].	Domain
I	PF05499	DNA methyltransferase 1-associated protein 1 (DMAP1) (DMAP1)	DNA methyltransferase 1-associated protein 1 (DMAP1)	-	Family
K	PF08265	YL1 nuclear protein C-terminal domain (YL1_C)	YL1 nuclear protein C-terminal domain	This domain is found in proteins of the YL1 family [1]. These proteins have been shown to be DNA-binding and may be a transcription factor [1]. This domain is found in proteins that are not YL1 proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth E], E [auth C], M [auth A]	RuvB-like 1	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity forked DNA-dependent helicase activity DNA helicase activity helicase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ADP binding cell adhesion molecule binding cadherin binding TBP-class protein binding ATPase binding enzyme binding double-stranded DNA helicase activity cohesin loader activity DNA clamp loader activity transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity ATP-dependent H2AZ histone chaperone activity single-stranded 3'-5' DNA helicase activity single-stranded DNA helicase activity 3'-5' DNA helicase activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular process cell division developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation regulation of protein stability biological regulation regulation of biological quality protein stabilization cellular process cell division regulation of biological process regulation of cellular process primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus response to stimulus positive regulation of biological process regulation of cellular response to stress positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress positive regulation of macromolecule metabolic process positive regulation of cellular process DNA repair positive regulation of nucleobase-containing compound metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of response to stimulus DNA damage response RNA localization to nucleus localization telomerase RNA localization macromolecule localization RNA localization to Cajal body telomerase RNA localization to Cajal body RNA localization regulation of DNA recombination regulation of double-strand break repair positive regulation of double-strand break repair via homologous recombination recombinational repair double-strand break repair via homologous recombination positive regulation of DNA recombination double-strand break repair DNA recombination positive regulation of double-strand break repair regulation of double-strand break repair via homologous recombination RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of organelle organization telomere maintenance in response to DNA damage telomere organization positive regulation of telomere maintenance regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization telomere maintenance regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization cellular component organization cellular component organization or biogenesis positive regulation of telomere maintenance in response to DNA damage regulation of telomere maintenance in response to DNA damage chromosome organization organelle organization ribonucleoprotein complex biogenesis protein-containing complex organization small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly box C/D snoRNP assembly positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process multicellular organismal process regulation of embryonic development regulation of multicellular organismal development regulation of developmental process embryo development multicellular organism development anatomical structure development regulation of multicellular organismal process transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of cell communication positive regulation of signal transduction signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway regulation of signal transduction cell communication positive regulation of Wnt signaling pathway signal transduction Wnt signaling pathway positive regulation of canonical Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway regulation of cell communication positive regulation of signaling cell cycle regulation of cell cycle regulation of DNA strand elongation DNA strand elongation chromatin organization chromatin remodeling	membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle SWI/SNF superfamily-type complex membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle SWI/SNF superfamily-type complex INO80-type complex catalytic complex intracellular membraneless organelle chromatin intracellular membrane-bounded organelle Ino80 complex organelle lumen organelle nuclear lumen membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol dynein axonemal particle protein folding chaperone complex intracellular protein-containing complex histone methyltransferase complex MLL1/2 complex transferase complex MLL1 complex nucleoplasm methyltransferase complex RPAP3/R2TP/prefoldin-like complex nuclear periphery nuclear matrix NuA4 histone acetyltransferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton R2TP complex protein-DNA complex nucleosome histone deacetylase complex Swr1 complex ribonucleoprotein complex
B [auth H]	Enhancer of polycomb homolog 1	chromatin-protein adaptor activity protein-macromolecule adaptor activity molecular adaptor activity enzyme-substrate adaptor activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus regulation of double-strand break repair response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair double-strand break repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis epigenetic regulation of gene expression negative regulation of gene expression negative regulation of gene expression, epigenetic developmental process spermatid development spermatid differentiation sexual reproduction cellular developmental process spermatogenesis reproductive process multicellular organismal reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction gamete generation male gamete generation cell differentiation anatomical structure development germ cell development regulation of DNA recombination positive regulation of biological process positive regulation of double-strand break repair via homologous recombination positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair recombinational repair positive regulation of macromolecule metabolic process double-strand break repair via homologous recombination positive regulation of cellular process positive regulation of DNA recombination positive regulation of nucleobase-containing compound metabolic process DNA recombination positive regulation of double-strand break repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process sperm DNA condensation nucleus organization organelle organization spermatid nucleus differentiation positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell cycle regulation of cell cycle negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex catalytic complex NuA4 histone acetyltransferase complex chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex nuclear membrane membrane endomembrane system organelle envelope nuclear envelope organelle membrane protein-DNA complex nucleosome cytoplasm nucleoplasm piccolo histone acetyltransferase complex site of double-strand break site of DNA damage nuclear body
C [auth M], L	Actin-like protein 6A	chromatin binding binding transcription coactivator activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle cellular process metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition developmental process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation myoblast differentiation positive regulation of cellular process primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process macromolecule metabolic process regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus response to stimulus regulation of cellular response to stress positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress positive regulation of macromolecule metabolic process DNA repair positive regulation of nucleobase-containing compound metabolic process regulation of DNA repair positive regulation of DNA metabolic process regulation of response to stimulus DNA damage response regulation of DNA recombination regulation of double-strand break repair positive regulation of double-strand break repair via homologous recombination recombinational repair double-strand break repair via homologous recombination positive regulation of DNA recombination double-strand break repair DNA recombination positive regulation of double-strand break repair regulation of double-strand break repair via homologous recombination RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription multicellular organism development multicellular organismal process nervous system development system development negative regulation of developmental process negative regulation of biological process negative regulation of cellular process negative regulation of cell differentiation positive regulation of organelle organization telomere maintenance in response to DNA damage telomere organization positive regulation of telomere maintenance positive regulation of chromosome organization telomere maintenance regulation of telomere maintenance positive regulation of cellular component organization positive regulation of telomere maintenance in response to DNA damage regulation of telomere maintenance in response to DNA damage sensory organ development eye development animal organ development retina development in camera-type eye visual system development neural retina development camera-type eye development sensory system development chordate embryonic development embryo development in utero embryonic development anatomical structure morphogenesis blastocyst formation embryo development ending in birth or egg hatching anatomical structure formation involved in morphogenesis blastocyst development spinal cord development central nervous system development regulation of stem cell population maintenance stem cell population maintenance positive regulation of stem cell population maintenance positive regulation of multicellular organismal process regulation of multicellular organismal process maintenance of cell number signaling signal transduction cell communication cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation nucleotide-excision repair regulation of nucleotide-excision repair positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of G0 to G1 transition G0 to G1 transition regulation of embryonic development regulation of multicellular organismal development transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle regulation of DNA strand elongation DNA strand elongation regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation T cell activation positive regulation of leukocyte activation T cell differentiation regulation of immune system process positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion leukocyte differentiation cell development positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis regulation of cell-cell adhesion regulation of lymphocyte differentiation hemopoiesis positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation immune system process regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation chromatin organization chromatin remodeling	membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle SWI/SNF superfamily-type complex membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle SWI/SNF superfamily-type complex INO80-type complex catalytic complex intracellular membraneless organelle chromatin intracellular membrane-bounded organelle Ino80 complex organelle lumen organelle nuclear lumen brahma complex GBAF complex SWI/SNF complex npBAF complex nuclear periphery nuclear matrix NuA4 histone acetyltransferase complex transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex RSC-type complex cell periphery plasma membrane membrane protein-DNA complex nucleosome nucleoplasm chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region supramolecular complex condensed chromosome
D [auth B], F [auth D], G [auth F]	RuvB-like 2	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity forked DNA-dependent helicase activity DNA helicase activity helicase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ADP binding TBP-class protein binding DNA binding chromatin binding double-stranded DNA binding DNA-DNA tethering activity nucleic acid binding chromatin DNA binding promoter-enhancer loop anchoring activity chromatin loop anchoring activity molecular adaptor activity sequence-specific DNA binding core promoter sequence-specific DNA binding RNA polymerase II core promoter sequence-specific DNA binding RNA polymerase II transcription regulatory region sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding transcription regulatory region nucleic acid binding ATPase binding enzyme binding identical protein binding double-stranded DNA helicase activity cohesin loader activity DNA clamp loader activity cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding ATP-dependent H2AZ histone chaperone activity transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity single-stranded 3'-5' DNA helicase activity single-stranded DNA helicase activity 3'-5' DNA helicase activity unfolded protein binding protein homodimerization activity protein dimerization activity four-way junction helicase activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides beta-catenin binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation regulation of protein stability biological regulation regulation of biological quality protein stabilization protein folding biosynthetic process metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process protein maturation regulation of biological process regulation of cellular process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process DNA replication regulation of nucleobase-containing compound metabolic process regulation of metabolic process regulation of DNA replication regulation of DNA metabolic process cellular response to stimulus response to stimulus signaling negative regulation of signaling regulation of canonical Wnt signaling pathway canonical Wnt signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication negative regulation of Wnt signaling pathway negative regulation of cellular process signal transduction Wnt signaling pathway regulation of signaling cell surface receptor signaling pathway regulation of Wnt signaling pathway negative regulation of response to stimulus negative regulation of signal transduction negative regulation of canonical Wnt signaling pathway regulation of response to stimulus regulation of cell communication regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death positive regulation of biological process regulation of cellular response to stress positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress positive regulation of macromolecule metabolic process positive regulation of cellular process DNA repair positive regulation of nucleobase-containing compound metabolic process regulation of DNA repair positive regulation of DNA metabolic process DNA damage response RNA localization to nucleus localization telomerase RNA localization macromolecule localization RNA localization to Cajal body telomerase RNA localization to Cajal body RNA localization regulation of DNA recombination regulation of double-strand break repair positive regulation of double-strand break repair via homologous recombination recombinational repair double-strand break repair via homologous recombination positive regulation of DNA recombination double-strand break repair DNA recombination positive regulation of double-strand break repair regulation of double-strand break repair via homologous recombination RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of organelle organization telomere maintenance in response to DNA damage telomere organization positive regulation of telomere maintenance regulation of chromosome organization regulation of organelle organization positive regulation of chromosome organization telomere maintenance regulation of telomere maintenance regulation of cellular component organization positive regulation of cellular component organization cellular component organization cellular component organization or biogenesis positive regulation of telomere maintenance in response to DNA damage regulation of telomere maintenance in response to DNA damage chromosome organization organelle organization positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process ribonucleoprotein complex biogenesis protein-containing complex organization small nucleolar ribonucleoprotein complex assembly protein-RNA complex assembly cellular component biogenesis protein-RNA complex organization cellular component assembly protein-containing complex assembly box C/D snoRNP assembly response to light stimulus cellular response to radiation response to UV cellular response to environmental stimulus cellular response to light stimulus response to radiation response to abiotic stimulus cellular response to abiotic stimulus cellular response to UV response to lipid response to oxygen-containing compound cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to lipid response to estradiol cellular response to estradiol stimulus developmental process multicellular organismal process regulation of embryonic development regulation of multicellular organismal development regulation of developmental process embryo development multicellular organism development anatomical structure development regulation of multicellular organismal process cell cycle regulation of cell cycle regulation of DNA strand elongation DNA strand elongation protein localization establishment of protein localization cellular localization protein localization to chromatin establishment of protein localization to chromatin establishment of localization establishment of protein localization to organelle protein localization to chromosome cellular macromolecule localization protein localization to organelle establishment of protein localization to chromosome chromatin organization chromatin remodeling	membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle SWI/SNF superfamily-type complex membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex nuclear chromosome chromosome intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle SWI/SNF superfamily-type complex INO80-type complex catalytic complex intracellular membraneless organelle chromatin intracellular membrane-bounded organelle Ino80 complex organelle lumen organelle nuclear lumen membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoplasm cytosol dynein axonemal particle protein folding chaperone complex intracellular protein-containing complex histone methyltransferase complex MLL1/2 complex transferase complex MLL1 complex nucleoplasm methyltransferase complex RPAP3/R2TP/prefoldin-like complex nuclear periphery nuclear matrix NuA4 histone acetyltransferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton R2TP complex protein-DNA complex nucleosome histone deacetylase complex Swr1 complex euchromatin ribonucleoprotein complex
H [auth G]	E1A-binding protein p400	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein antigen binding protein binding binding antigen binding chromatin binding hydrolase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein antigen binding protein binding binding antigen binding chromatin binding hydrolase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding	regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation cellular process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus regulation of double-strand break repair response to stimulus regulation of cellular response to stress regulation of primary metabolic process regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation cellular process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus regulation of double-strand break repair response to stimulus regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process cellular response to stress response to stress regulation of response to stress regulation of nucleobase-containing compound metabolic process DNA repair double-strand break repair primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA recombination positive regulation of biological process positive regulation of double-strand break repair via homologous recombination positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair recombinational repair positive regulation of macromolecule metabolic process double-strand break repair via homologous recombination positive regulation of cellular process positive regulation of DNA recombination positive regulation of nucleobase-containing compound metabolic process DNA recombination positive regulation of double-strand break repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cell cycle regulation of cell cycle cellular component organization chromatin organization cellular component organization or biogenesis	protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure organelle membraneless organelle protein acetyltransferase complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen protein-DNA complex nucleosome ATPase complex nuclear protein-containing complex nuclear chromosome histone deacetylase complex SWI/SNF superfamily-type complex INO80-type complex Swr1 complex
I	DNA methyltransferase 1-associated protein 1	transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding transcription corepressor activity transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus regulation of double-strand break repair response to stimulus regulation of cellular response to stress cellular response to stress response to stress regulation of response to stress DNA repair double-strand break repair DNA metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus regulation of DNA metabolic process protein localization regulation of localization cellular localization establishment of protein localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of biological process positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus positive regulation of intracellular transport positive regulation of cellular process regulation of intracellular transport regulation of transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization establishment of protein localization to organelle positive regulation of transport regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport response to alcohol response to chemical response to oxygen-containing compound response to ethanol regulation of DNA recombination positive regulation of double-strand break repair via homologous recombination positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair recombinational repair positive regulation of macromolecule metabolic process double-strand break repair via homologous recombination positive regulation of DNA recombination positive regulation of nucleobase-containing compound metabolic process DNA recombination positive regulation of double-strand break repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process cell cycle regulation of cell cycle transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis	protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure organelle membraneless organelle protein acetyltransferase complex intracellular protein-containing complex cytoplasm cytosol protein-DNA complex nucleosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen replication fork ATPase complex nuclear protein-containing complex nuclear chromosome histone deacetylase complex SWI/SNF superfamily-type complex INO80-type complex Swr1 complex
J	Actin, cytoplasmic 1	structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding structural constituent of postsynapse structural constituent of cytoskeleton structural molecule activity structural constituent of synapse structural constituent of postsynaptic actin cytoskeleton binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cytoskeletal protein binding protein binding tau protein binding nitric-oxide synthase binding enzyme binding identical protein binding kinesin binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding Tat protein binding kinase binding protein kinase binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation regulation of chromosome segregation regulation of cell cycle phase transition regulation of cellular process regulation of metaphase/anaphase transition of cell cycle regulation of cellular component organization cell cycle phase transition regulation of mitotic metaphase/anaphase transition mitotic cell cycle cellular component organization regulation of mitotic cell cycle cell cycle cellular component organization or biogenesis regulation of cell cycle chromosome segregation cell cycle process regulation of biological process regulation of cell cycle process biological regulation chromosome organization sister chromatid segregation regulation of chromosome organization regulation of organelle organization regulation of mitotic cell cycle phase transition organelle organization mitotic cell cycle process regulation of sister chromatid segregation nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle cellular process metaphase/anaphase transition of cell cycle mitotic cell cycle phase transition developmental process regulation of developmental process cellular developmental process positive regulation of biological process regulation of cell differentiation positive regulation of myoblast differentiation muscle structure development positive regulation of developmental process positive regulation of cell differentiation cell differentiation anatomical structure development regulation of myoblast differentiation myoblast differentiation positive regulation of cellular process multicellular organismal process regulation of body fluid levels wound healing response to stimulus homotypic cell-cell adhesion cell activation hemostasis platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to nitrogen compound cellular response to stimulus response to cytochalasin B response to oxygen-containing compound response to nitrogen compound cellular response to oxygen-containing compound cellular response to cytochalasin B cellular response to chemical stimulus response to chemical regulation of localization import into cell cellular localization transport synaptic vesicle cycle regulation of synaptic vesicle recycling vesicle-mediated transport presynaptic endocytosis vesicle-mediated transport in synapse localization synaptic vesicle recycling regulation of synaptic vesicle endocytosis establishment of localization in cell regulation of endocytosis synaptic vesicle endocytosis regulation of transport regulation of vesicle-mediated transport establishment of localization endocytosis axonogenesis cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis multicellular organism development cell projection morphogenesis neuron differentiation neuron projection morphogenesis system development plasma membrane bounded cell projection organization nervous system development axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development tissue morphogenesis epithelium development morphogenesis of a polarized epithelium morphogenesis of an epithelium tissue development regulation of DNA recombination regulation of double-strand break repair regulation of cellular response to stress positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination DNA repair positive regulation of DNA recombination double-strand break repair positive regulation of nucleobase-containing compound metabolic process DNA recombination primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process monoamine transport norepinephrine transport nitrogen compound transport organic hydroxy compound transport organic cation transport catecholamine uptake catecholamine transport regulation of norepinephrine uptake norepinephrine uptake establishment or maintenance of cell polarity protein localization protein localization to cell periphery regulation of protein localization protein localization to plasma membrane regulation of protein localization to cell periphery localization within membrane protein localization to membrane regulation of cellular localization cellular macromolecule localization macromolecule localization regulation of protein localization to plasma membrane regulation of protein localization to membrane negative regulation of developmental process negative regulation of biological process negative regulation of cellular process negative regulation of cell differentiation cell motility regulation of protein modification process regulation of catalytic activity regulation of protein phosphorylation regulation of transferase activity regulation of cyclin-dependent protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process protein metabolic process phosphorus metabolic process protein modification process protein phosphorylation phosphorylation regulation of protein metabolic process regulation of protein kinase activity regulation of molecular function regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorylation regulation of phosphorus metabolic process adherens junction organization adherens junction assembly cellular component biogenesis cell junction organization cellular component assembly cell junction assembly cell-cell junction assembly cell-cell junction organization transepithelial transport regulation of transepithelial transport apical protein localization positive regulation of norepinephrine uptake positive regulation of transport regulation of transmembrane transporter activity regulation of transporter activity transmembrane transport regulation of transmembrane transport regulation of stem cell population maintenance stem cell population maintenance positive regulation of stem cell population maintenance positive regulation of multicellular organismal process regulation of multicellular organismal process maintenance of cell number cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation head development animal organ development brain development substantia nigra development central nervous system development midbrain development neural nucleus development nucleotide-excision repair regulation of nucleotide-excision repair positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of G0 to G1 transition G0 to G1 transition maintenance of blood-brain barrier multicellular organismal-level homeostasis homeostatic process anatomical structure homeostasis tissue homeostasis protein localization to cell junction protein localization to adherens junction protein localization to cell-cell junction transcription by RNA polymerase II regulation of transcription by RNA polymerase II regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation mononuclear cell differentiation lymphocyte differentiation positive regulation of T cell differentiation regulation of cell development positive regulation of cell activation T cell activation positive regulation of leukocyte activation T cell differentiation regulation of immune system process positive regulation of immune system process positive regulation of T cell activation positive regulation of cell development regulation of leukocyte cell-cell adhesion leukocyte differentiation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of hemopoiesis regulation of cell-cell adhesion regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation immune system process regulation of hemopoiesis positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation chromatin organization chromatin remodeling	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure catalytic complex cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium membrane cell-cell junction anchoring junction cell junction membrane-bounded organelle ATPase complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex intracellular membraneless organelle chromatin chromosome intracellular membrane-bounded organelle intracellular organelle organelle membraneless organelle SWI/SNF superfamily-type complex brahma complex GBAF complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytoskeleton actin cytoskeleton cytoplasm cytosol SWI/SNF complex cluster of actin-based cell projections brush border synapse glutamatergic synapse apical junction complex adherens junction nBAF complex axon neuron projection axon terminus presynapse distal axon calyx of Held neuron projection terminus npBAF complex polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex cell cortex cortical cytoskeleton cell periphery membrane-enclosed lumen intracellular organelle lumen organelle lumen nuclear periphery nuclear lumen nuclear matrix focal adhesion cell-substrate junction postsynapse postsynaptic cytoskeleton postsynaptic actin cytoskeleton NuA4 histone acetyltransferase complex transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex RSC-type complex dense body plasma membrane protein-DNA complex nucleosome nucleoplasm bBAF complex cytoplasmic ribonucleoprotein granule ribonucleoprotein granule blood microparticle chromosomal region kinetochore chromosome, centromeric region condensed chromosome, centromeric region condensed chromosome Schaffer collateral - CA1 synapse tight junction ribonucleoprotein complex
K	Vacuolar protein sorting-associated protein 72 homolog	DNA binding binding nucleic acid binding protein binding histone binding protein carrier chaperone histone chaperone activity molecular carrier activity	cellular response to stimulus regulation of DNA recombination regulation of cellular process response to stimulus regulation of double-strand break repair regulation of cellular response to stress positive regulation of biological process positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress cellular response to stimulus regulation of DNA recombination regulation of cellular process response to stimulus regulation of double-strand break repair regulation of cellular response to stress positive regulation of biological process positive regulation of double-strand break repair via homologous recombination regulation of primary metabolic process nucleobase-containing compound metabolic process positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair cellular response to stress response to stress regulation of response to stress recombinational repair positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process double-strand break repair via homologous recombination positive regulation of cellular process DNA repair positive regulation of DNA recombination double-strand break repair regulation of biological process positive regulation of nucleobase-containing compound metabolic process DNA recombination biological regulation primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process positive regulation of double-strand break repair regulation of DNA repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process DNA damage response regulation of response to stimulus metabolic process cellular process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling cellular component organization or biogenesis transcription initiation at RNA polymerase II promoter regulation of biosynthetic process epigenetic regulation of gene expression gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process developmental process multicellular organismal process somatic stem cell population maintenance maintenance of cell number stem cell population maintenance regulation of apoptotic process apoptotic process regulation of programmed cell death cell death programmed cell death cell cycle regulation of cell cycle negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process	protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure organelle membraneless organelle protein acetyltransferase complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen protein-DNA complex nucleosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth E], E [auth C], M [auth A]	IPR010339	TIP49, P-loop domain	Domain
A [auth E], E [auth C], M [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth E], E [auth C], M [auth A]	IPR041048	RuvB-like, AAA-lid domain	Domain
A [auth E], E [auth C], M [auth A]	IPR042487	RuvBL1/2, DNA/RNA binding domain	Homologous Superfamily
A [auth E], E [auth C], M [auth A]	IPR003593	AAA+ ATPase domain	Domain
A [auth E], E [auth C], M [auth A]	IPR027238	RuvB-like	Family
B [auth H]	IPR024943	Enhancer of polycomb protein	Family
B [auth H]	IPR019542	Enhancer of polycomb-like, N-terminal	Domain
B [auth H]	IPR009607	Enhancer of polycomb, C-terminal	Domain
C [auth M], L	IPR004001	Actin, conserved site	Conserved Site
C [auth M], L	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
C [auth M], L	IPR004000	Actin family	Family
D [auth B], F [auth D], G [auth F]	IPR010339	TIP49, P-loop domain	Domain
D [auth B], F [auth D], G [auth F]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
D [auth B], F [auth D], G [auth F]	IPR041048	RuvB-like, AAA-lid domain	Domain
D [auth B], F [auth D], G [auth F]	IPR042487	RuvBL1/2, DNA/RNA binding domain	Homologous Superfamily
D [auth B], F [auth D], G [auth F]	IPR003593	AAA+ ATPase domain	Domain
D [auth B], F [auth D], G [auth F]	IPR027238	RuvB-like	Family
H [auth G]	IPR000330	SNF2, N-terminal	Domain
H [auth G]	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
H [auth G]	IPR031575	E1A-binding protein p400, N-terminal	Domain
H [auth G]	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
H [auth G]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
H [auth G]	IPR001650	Helicase, C-terminal domain-like	Domain
H [auth G]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
H [auth G]	IPR001005	SANT/Myb domain	Domain
H [auth G]	IPR014012	Helicase/SANT-associated domain	Domain
I	IPR027109	SWR1-complex protein 4/DNA methyltransferase 1-associated protein 1	Family
I	IPR032563	DAMP1, SANT/Myb-like domain	Domain
I	IPR008468	DNA methyltransferase 1-associated 1	Domain
J	IPR020902	Actin/actin-like conserved site	Conserved Site
J	IPR004001	Actin, conserved site	Conserved Site
J	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
J	IPR004000	Actin family	Family
K	IPR013272	Vps72/YL1, C-terminal	Domain
K	IPR046757	Vps72/YL1, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth E], E [auth C], M [auth A]	Pharos: Q9Y265	atypical teratoid rhabdoid tumor hypospadias lung cancer malignant glioma non-small cell lung carcinoma prostate carcinoma chronic obstructive pulmonary disease invasive ductal breast carcinoma malignant colon neoplasm malignant mesothelioma ovarian cancer glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma atypical teratoid rhabdoid tumor hypospadias lung cancer malignant glioma non-small cell lung carcinoma prostate carcinoma chronic obstructive pulmonary disease invasive ductal breast carcinoma malignant colon neoplasm malignant mesothelioma ovarian cancer glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma primitive neuroectodermal tumor
B [auth H]	Pharos: Q9H2F5	breast cancer osteosarcoma tuberculosis hepatocellular carcinoma ovarian cancer medulloblastoma rheumatoid arthritis
C [auth M], L	Pharos: O96019	pilocytic astrocytoma acute myeloid leukemia breast cancer glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor gastric cancer hepatocellular carcinoma lung adenocarcinoma malignant glioma non-small cell lung carcinoma pilocytic astrocytoma acute myeloid leukemia breast cancer glioblastoma large cell medulloblastoma malignant ependymoma medulloblastoma osteosarcoma primitive neuroectodermal tumor astrocytic tumor gastric cancer hepatocellular carcinoma lung adenocarcinoma malignant glioma non-small cell lung carcinoma ovarian cancer psoriasis atypical teratoid rhabdoid tumor gastric carcinoma intellectual disability lung cancer malignant mesothelioma oligodendroglioma
D [auth B], F [auth D], G [auth F]	Pharos: Q9Y230	diabetes mellitus osteosarcoma Sjogren syndrome lung cancer ovarian cancer malignant colon neoplasm plasma cell myeloma
H [auth G]	Pharos: Q96L91	lung cancer ovarian cancer rheumatoid arthritis medulloblastoma pancreatic intraductal papillary-mucinous carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia
I	Pharos: Q9NPF5	medulloblastoma ovarian cancer
J	Pharos: P60709	developmental malformations-deafness-dystonia syndrome coloboma dystonic disorder Baraitser-Winter cerebrofrontofacial syndrome intellectual disability Neoplasm Invasiveness Baraitser-Winter syndrome 1 carcinoma dysostosis esophageal cancer sarcomatoid carcinoma ovarian cancer central nervous system malformation pancreatic intraductal papillary-mucinous neoplasm large cell medulloblastoma developmental malformations-deafness-dystonia syndrome coloboma dystonic disorder Baraitser-Winter cerebrofrontofacial syndrome intellectual disability Neoplasm Invasiveness Baraitser-Winter syndrome 1 carcinoma dysostosis esophageal cancer sarcomatoid carcinoma ovarian cancer central nervous system malformation pancreatic intraductal papillary-mucinous neoplasm large cell medulloblastoma plasma cell myeloma liver disease prostate disease lung disease schizophrenia drug-induced liver injury mammary neoplasms, animal arthritic joint disease stomach disease multiple endocrine neoplasia type 2A atypical teratoid rhabdoid tumor uterine disease glioblastoma obesity disorder Borst-Jadassohn intraepidermal carcinoma hepatocellular carcinoma ovarian disease cerebrovascular disorder pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia colonic disease linear and whorled nevoid hypermelanosis primary cutaneous amyloidosis coronary artery disease lung adenocarcinoma rheumatoid arthritis craniosynostosis malignant ependymoma seborrheic keratosis malignant pancreatic neoplasm skin basal cell carcinoma astrocytic tumor type 2 diabetes mellitus mycosis fungoides autoimmune disease vertebral column disease neoplasm of esophagus Becker nevus syndrome head and neck cancer osteoarthritis breast disease hyperglycemia osteosarcoma pancreatic ductal adenocarcinoma chronic obstructive pulmonary disease kidney disease pilocytic astrocytoma primitive neuroectodermal tumor lung benign neoplasm lymphatic system disease dermatomyositis malignant glioma Down syndrome skin disease medulloblastoma atherosclerosis undifferentiated carcinoma myocardial ischemia X-linked mixed deafness with perilymphatic gusher eye disease neurodegenerative disease bipolar disorder hematologic disease osteoarthritis susceptibility 1 cancer hypertensive disorder
K	Pharos: Q15906	acute myeloid leukemia lung cancer medulloblastoma ovarian cancer heart disease malignant mesothelioma myocardial infarction tuberculosis lung adenocarcinoma Malignant neoplasm of breast osteosarcoma