Annotations: 9C47

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF20206	Tra1 HEAT repeat ring region (Tra1_ring)	Tra1 HEAT repeat ring region	-	Repeat
A [auth C]	PF00454	Phosphatidylinositol 3- and 4-kinase (PI3_PI4_kinase)	Phosphatidylinositol 3- and 4-kinase	-	Family
A [auth C]	PF02259	FAT domain (FAT)	FAT domain	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	Transformation/transcription domain-associated protein	transcription regulator activity transcription coregulator activity protein-macromolecule adaptor activity molecular adaptor activity	cellular response to stimulus DNA repair-dependent chromatin remodeling response to stimulus cellular component organization cellular response to stress DNA damage response chromatin organization response to stress chromatin remodeling cellular process cellular component organization or biogenesis regulation of biological process regulation of cellular process regulation of apoptotic process cellular response to stimulus DNA repair-dependent chromatin remodeling response to stimulus cellular component organization cellular response to stress DNA damage response chromatin organization response to stress chromatin remodeling cellular process cellular component organization or biogenesis regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation apoptotic process regulation of programmed cell death cell death programmed cell death regulation of double-strand break repair regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process regulation of response to stress regulation of nucleobase-containing compound metabolic process DNA repair double-strand break repair primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA recombination positive regulation of biological process positive regulation of double-strand break repair via homologous recombination positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair recombinational repair positive regulation of macromolecule metabolic process double-strand break repair via homologous recombination positive regulation of cellular process positive regulation of DNA recombination positive regulation of nucleobase-containing compound metabolic process DNA recombination positive regulation of double-strand break repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process RNA metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process transcription by RNA polymerase II regulation of transcription by RNA polymerase II cell cycle regulation of cell cycle RNA processing RNA splicing regulation of RNA splicing	protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure organelle membraneless organelle protein acetyltransferase complex intracellular protein-containing complex protein-DNA complex nucleosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen peptidase complex SAGA-type complex SAGA complex RNA polymerase II transcription regulator complex transcription factor TFTC complex RNA polymerase II, holoenzyme nuclear protein-containing complex transcription regulator complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex Golgi apparatus cytoplasm endomembrane system ATPase complex nuclear chromosome histone deacetylase complex SWI/SNF superfamily-type complex INO80-type complex Swr1 complex
B [auth G]	E1A-binding protein p400	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein antigen binding protein binding binding antigen binding chromatin binding hydrolase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity protein antigen binding protein binding binding antigen binding chromatin binding hydrolase activity adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding nucleic acid binding	regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation cellular process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus regulation of double-strand break repair response to stimulus regulation of cellular response to stress regulation of primary metabolic process regulation of biological process regulation of cellular process regulation of apoptotic process biological regulation cellular process apoptotic process regulation of programmed cell death cell death programmed cell death cellular response to stimulus regulation of double-strand break repair response to stimulus regulation of cellular response to stress regulation of primary metabolic process nucleobase-containing compound metabolic process cellular response to stress response to stress regulation of response to stress regulation of nucleobase-containing compound metabolic process DNA repair double-strand break repair primary metabolic process DNA metabolic process regulation of macromolecule metabolic process nucleic acid metabolic process regulation of DNA repair DNA damage response regulation of response to stimulus metabolic process macromolecule metabolic process regulation of metabolic process regulation of DNA metabolic process regulation of DNA recombination positive regulation of biological process positive regulation of double-strand break repair via homologous recombination positive regulation of response to stimulus positive regulation of metabolic process positive regulation of DNA repair recombinational repair positive regulation of macromolecule metabolic process double-strand break repair via homologous recombination positive regulation of cellular process positive regulation of DNA recombination positive regulation of nucleobase-containing compound metabolic process DNA recombination positive regulation of double-strand break repair regulation of double-strand break repair via homologous recombination positive regulation of DNA metabolic process positive regulation of DNA-templated transcription RNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process positive regulation of biosynthetic process regulation of RNA biosynthetic process regulation of biosynthetic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process positive regulation of RNA metabolic process regulation of gene expression biosynthetic process positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cell cycle regulation of cell cycle cellular component organization chromatin organization cellular component organization or biogenesis	protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure protein-containing complex intracellular anatomical structure catalytic complex NuA4 histone acetyltransferase complex intracellular membraneless organelle chromatin chromosome transferase complex H4/H2A histone acetyltransferase complex histone acetyltransferase complex acetyltransferase complex H4 histone acetyltransferase complex intracellular organelle cellular anatomical structure organelle membraneless organelle protein acetyltransferase complex intracellular protein-containing complex membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body nucleoplasm organelle lumen nuclear lumen protein-DNA complex nucleosome ATPase complex nuclear protein-containing complex nuclear chromosome histone deacetylase complex SWI/SNF superfamily-type complex INO80-type complex Swr1 complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR016024	Armadillo-type fold	Homologous Superfamily
A [auth C]	IPR003152	FATC domain	Domain
A [auth C]	IPR011989	Armadillo-like helical	Homologous Superfamily
A [auth C]	IPR046805	Tra1, HEAT repeat ring region	Repeat
A [auth C]	IPR000403	Phosphatidylinositol 3-/4-kinase, catalytic domain	Domain
A [auth C]	IPR046807	Tra1, HEAT repeat central region	Repeat
A [auth C]	IPR050517	DNA Damage Response and Repair Kinase	Family
A [auth C]	IPR003151	PIK-related kinase, FAT	Domain
A [auth C]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A [auth C]	IPR014009	PIK-related kinase	Domain
B [auth G]	IPR000330	SNF2, N-terminal	Domain
B [auth G]	IPR049730	SNF2/RAD5-like, C-terminal helicase domain	Domain
B [auth G]	IPR031575	E1A-binding protein p400, N-terminal	Domain
B [auth G]	IPR038718	SNF2-like, N-terminal domain superfamily	Homologous Superfamily
B [auth G]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth G]	IPR001650	Helicase, C-terminal domain-like	Domain
B [auth G]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
B [auth G]	IPR001005	SANT/Myb domain	Domain
B [auth G]	IPR014012	Helicase/SANT-associated domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth C]	Pharos: Q9Y4A5	melanoma schizophrenia cutaneous melanoma ovarian mucinous adenocarcinoma adenoma atypical teratoid rhabdoid tumor gastric adenocarcinoma large cell medulloblastoma malignant ependymoma osteosarcoma ovarian serous adenocarcinoma subependymal giant cell astrocytoma adrenal cortex carcinoma colorectal adenocarcinoma Gaucher disease melanoma schizophrenia cutaneous melanoma ovarian mucinous adenocarcinoma adenoma atypical teratoid rhabdoid tumor gastric adenocarcinoma large cell medulloblastoma malignant ependymoma osteosarcoma ovarian serous adenocarcinoma subependymal giant cell astrocytoma adrenal cortex carcinoma colorectal adenocarcinoma Gaucher disease lung adenocarcinoma malignant mesothelioma nonsyndromic genetic deafness ovarian cancer primitive neuroectodermal tumor astrocytic tumor glioblastoma lung large cell carcinoma medulloblastoma oligodendroglioma
B [auth G]	Pharos: Q96L91	lung cancer ovarian cancer rheumatoid arthritis medulloblastoma pancreatic intraductal papillary-mucinous carcinoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.