8RO7

Human cohesin SMC1A-HD(longCC)/RAD21-C complex - Open/closed P-loop conformation

External Resource: Annotation

Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Structural maintenance of chromosomes protein 1A (SMC1A)	chromatin binding binding protein heterodimerization activity protein binding protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding protein-containing complex binding mediator complex binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding chromatin binding binding protein heterodimerization activity protein binding protein dimerization activity RNA binding organic cyclic compound binding nucleic acid binding protein-containing complex binding mediator complex binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding DNA binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity ATP-dependent activity	cellular process cell division cellular response to biotic stimulus cellular response to stimulus cellular response to endogenous stimulus response to stimulus response to DNA integrity checkpoint signaling response to DNA damage checkpoint signaling response to endogenous stimulus response to cell cycle checkpoint signaling response to biotic stimulus response to radiation response to abiotic stimulus cellular component organization cellular process cell division cellular response to biotic stimulus cellular response to stimulus cellular response to endogenous stimulus response to stimulus response to DNA integrity checkpoint signaling response to DNA damage checkpoint signaling response to endogenous stimulus response to cell cycle checkpoint signaling response to biotic stimulus response to radiation response to abiotic stimulus cellular component organization organelle organization chromosome organization sister chromatid cohesion cellular component organization or biogenesis cell cycle cell cycle process mitotic nuclear division organelle fission sister chromatid segregation mitotic cell cycle nuclear division mitotic cell cycle process mitotic sister chromatid segregation nuclear chromosome segregation chromosome segregation mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion establishment of sister chromatid cohesion primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process cellular response to stress DNA damage response response to stress metabolic process macromolecule metabolic process DNA repair establishment of meiotic sister chromatid cohesion meiotic sister chromatid cohesion microtubule cytoskeleton organization membraneless organelle assembly cellular component biogenesis cellular component assembly microtubule cytoskeleton organization involved in mitosis spindle organization organelle assembly spindle assembly mitotic spindle organization mitotic spindle assembly microtubule-based process cytoskeleton organization developmental process multicellular organismal process somatic stem cell population maintenance maintenance of cell number stem cell population maintenance sexual reproduction reproductive process meiotic cell cycle	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix condensed nuclear chromosome membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix condensed nuclear chromosome intracellular membraneless organelle nuclear chromosome chromosome membraneless organelle condensed chromosome cytoplasm cytosol chromosome, centromeric region chromosomal region protein-containing complex mitotic cohesin complex cohesin complex nucleoplasm kinetochore condensed chromosome, centromeric region supramolecular complex mitotic spindle spindle cytoskeleton mitotic spindle pole spindle pole microtubule cytoskeleton meiotic cohesin complex
B	64-kDa C-terminal product	RNA binding binding organic cyclic compound binding lncRNA binding nucleic acid binding chromatin binding DNA binding transcription factor binding protein binding DNA-binding transcription factor binding	cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process replication-born double-strand break repair via sister chromatid exchange cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular response to stimulus double-strand break repair response to stimulus DNA recombination primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process replication-born double-strand break repair via sister chromatid exchange cellular response to stress DNA damage response response to stress recombinational repair metabolic process cellular process macromolecule metabolic process double-strand break repair via homologous recombination DNA repair multicellular organismal process regulation of tumor necrosis factor production regulation of cellular process negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process regulation of multicellular organismal process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process regulation of metabolic process homologous recombination sexual reproduction reproductive process meiotic cell cycle process cellular component organization meiosis I meiotic nuclear division cell cycle cellular component organization or biogenesis reciprocal homologous recombination cell cycle process meiotic cell cycle organelle fission reciprocal meiotic recombination nuclear division organelle organization meiosis I cell cycle process cell division regulation of cell cycle phase transition G2/M transition of mitotic cell cycle negative regulation of cell cycle cell cycle phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle negative regulation of cell cycle phase transition regulation of cell cycle cell cycle G2/M phase transition negative regulation of mitotic cell cycle phase transition regulation of G2/M transition of mitotic cell cycle regulation of cell cycle process regulation of cell cycle G2/M phase transition negative regulation of cell cycle process regulation of mitotic cell cycle phase transition mitotic cell cycle process negative regulation of cell cycle G2/M phase transition negative regulation of G2/M transition of mitotic cell cycle mitotic cell cycle phase transition chromosome segregation protein localization localization protein localization to chromatin cellular localization protein localization to chromosome protein localization to organelle cellular macromolecule localization macromolecule localization apoptotic process cell death programmed cell death interleukin-1 production regulation of interleukin-1 beta production negative regulation of interleukin-1 beta production negative regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production chromosome organization sister chromatid cohesion positive regulation of organelle organization regulation of cellular component organization positive regulation of cellular component organization positive regulation of biological process positive regulation of cell cycle process positive regulation of cellular process regulation of chromosome organization positive regulation of sister chromatid cohesion regulation of organelle organization positive regulation of cell cycle positive regulation of chromosome organization regulation of sister chromatid cohesion mitotic sister chromatid cohesion establishment of mitotic sister chromatid cohesion establishment of sister chromatid cohesion neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death negative regulation of apoptotic process regulation of neuron apoptotic process chromatin looping chromatin organization interleukin-10 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of interleukin-10 production positive regulation of interleukin-10 production positive regulation of gene expression positive regulation of multicellular organismal process positive regulation of cytokine production response to decreased oxygen levels response to hypoxia response to oxygen levels response to abiotic stimulus establishment of meiotic sister chromatid cohesion meiotic sister chromatid cohesion regulation of glial cell apoptotic process negative regulation of glial cell apoptotic process glial cell apoptotic process RNA metabolic process regulation of primary metabolic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process regulation of DNA-templated transcription regulation of mitotic nuclear division negative regulation of mitotic sister chromatid segregation negative regulation of chromosome organization mitotic sister chromatid separation negative regulation of sister chromatid segregation negative regulation of cellular component organization sister chromatid segregation regulation of mitotic sister chromatid segregation regulation of chromosome separation negative regulation of mitotic nuclear division regulation of chromosome segregation regulation of mitotic sister chromatid separation regulation of metaphase/anaphase transition of cell cycle regulation of mitotic metaphase/anaphase transition mitotic sister chromatid segregation negative regulation of mitotic metaphase/anaphase transition negative regulation of chromosome separation mitotic nuclear division negative regulation of chromosome segregation chromosome separation negative regulation of organelle organization negative regulation of nuclear division regulation of sister chromatid segregation negative regulation of mitotic sister chromatid separation regulation of nuclear division negative regulation of metaphase/anaphase transition of cell cycle nuclear chromosome segregation metaphase/anaphase transition of mitotic cell cycle metaphase/anaphase transition of cell cycle	midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix midbody cellular anatomical structure membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle organelle lumen organelle nuclear periphery nuclear lumen nuclear matrix cytoskeleton spindle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane condensed nuclear chromosome nuclear chromosome chromosome condensed chromosome cytoplasm cytosol chromosome, centromeric region chromosomal region protein-containing complex mitotic cohesin complex cohesin complex nucleoplasm chromatin meiotic cohesin complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028468	Smc1, ATP-binding cassette domain	Domain
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A	IPR010935	SMCs flexible hinge	Domain
A	IPR036277	SMCs flexible hinge superfamily	Homologous Superfamily
A	IPR003395	RecF/RecN/SMC, N-terminal	Domain
A	IPR024704	Structural maintenance of chromosomes protein	Family
B	IPR023093	ScpA-like, C-terminal	Homologous Superfamily
B	IPR049589	NXP-1, middle HEAT-repeat binding domain	Domain
B	IPR039781	Rad21/Rec8-like protein	Family
B	IPR006910	Rad21/Rec8-like protein, N-terminal	Domain
B	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
B	IPR006909	Rad21/Rec8-like protein, C-terminal, eukaryotic	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q14683	Cornelia de Lange syndrome myeloid leukemia Cornelia de Lange syndrome 2 adenoid cystic carcinoma salivary gland adenoid cystic carcinoma epilepsy chronic monocytic leukemia urinary bladder cancer intellectual disability lung adenocarcinoma malignant glioma myopathy neurofibromatosis type 1 osteosarcoma atypical teratoid rhabdoid tumor Cornelia de Lange syndrome myeloid leukemia Cornelia de Lange syndrome 2 adenoid cystic carcinoma salivary gland adenoid cystic carcinoma epilepsy chronic monocytic leukemia urinary bladder cancer intellectual disability lung adenocarcinoma malignant glioma myopathy neurofibromatosis type 1 osteosarcoma atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia congenital anemia primitive neuroectodermal tumor Roberts syndrome Cornelia de Lange syndrome 3 urinary bladder neoplasm Down syndrome glioblastoma juvenile dermatomyositis lymphoplasmacytic lymphoma medulloblastoma nasopharyngeal carcinoma oligodendroglioma adenoma ovarian cancer breast cancer pilocytic astrocytoma psoriasis Cytopenia Wiedemann-Steiner syndrome large cell medulloblastoma malignant ependymoma osteogenesis imperfecta astrocytic tumor pancreatic intraductal papillary-mucinous carcinoma dermatomyositis
B	Pharos: O60216	Cornelia de Lange syndrome myeloid leukemia Leukemia, Megakaryoblastic, of Down Syndrome Cornelia de Lange syndrome 4 chronic monocytic leukemia intellectual disability lung carcinoma malignant mesothelioma medulloblastoma acute myeloid leukemia oligodendroglioma breast cancer rheumatoid arthritis colorectal adenoma endometrium carcinoma in situ Cornelia de Lange syndrome myeloid leukemia Leukemia, Megakaryoblastic, of Down Syndrome Cornelia de Lange syndrome 4 chronic monocytic leukemia intellectual disability lung carcinoma malignant mesothelioma medulloblastoma acute myeloid leukemia oligodendroglioma breast cancer rheumatoid arthritis colorectal adenoma endometrium carcinoma in situ invasive ductal breast carcinoma lung adenocarcinoma Mungan syndrome astrocytic tumor osteosarcoma primitive neuroectodermal tumor Roberts syndrome colorectal cancer Cornelia de Lange syndrome 2 glioblastoma large cell medulloblastoma lung cancer malignant ependymoma plasma cell myeloma atypical teratoid rhabdoid tumor colorectal adenocarcinoma trichorhinophalangeal syndrome type II congenital anemia Cornelia de Lange syndrome 3 endometrial carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.