Annotations: 8KHR

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
E [auth B]	SCOP2B Superfamily	Interleukin 8-like chemokines	8105475	3001955	SCOP2B (2022-06-29)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth H]	Heavy Chain	IGHV1	-	soluble gp42 \| envelope glycoprotein h \| envelope glycoprotein l	SAbDab (2025-03-21)
C [auth L]	Light Chain	IGKV1	Kappa	soluble gp42 \| envelope glycoprotein h \| envelope glycoprotein l	SAbDab (2025-03-21)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
D [auth A]	PF17488	Herpesvirus glycoprotein H C-terminal domain (Herpes_glycoH_C)	Herpesvirus glycoprotein H C-terminal domain	Herpesvirus glycoprotein H (gH) is a virion associated envelope glycoprotein [2]. Complex formation between gH and gL has been demonstrated in both virions and infected cells [1]. This entry represents the C-terminal domain.	Domain
E [auth B]	PF11108	Viral glycoprotein L (Phage_glycop_gL)	Viral glycoprotein L	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	Soluble gp42	binding carbohydrate binding	-	cellular anatomical structure membrane virion component virion membrane
B [auth H]	2C1 heavy chain	-	-	-
C [auth L]	2C1 light chain	-	-	-
D [auth A]	Envelope glycoprotein H	-	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	virion component viral membrane viral envelope cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular membrane-bounded organelle host intracellular part host cell cytoplasm part host intracellular organelle virion component viral membrane viral envelope cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular membrane-bounded organelle host intracellular part host cell cytoplasm part host intracellular organelle host cell endosome membrane host cell cytoplasm host cell endosome host intracellular region
E [auth B]	Envelope glycoprotein L	-	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	virion component viral membrane viral envelope cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell cytoplasm host cell Golgi apparatus host intracellular region virion component viral membrane viral envelope cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane virion membrane host intracellular part host cell cytoplasm host cell Golgi apparatus host intracellular region host cell cytoplasm part

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR016186	C-type lectin-like/link domain superfamily	Homologous Superfamily
A [auth C]	IPR016187	C-type lectin fold	Homologous Superfamily
D [auth A]	IPR038172	Herpesvirus glycoprotein H, C-terminal domain superfamily	Homologous Superfamily
D [auth A]	IPR003493	Herpesvirus glycoprotein H	Family
D [auth A]	IPR035305	Herpesvirus glycoprotein H, C-terminal	Domain
E [auth B]	IPR034708	Envelope glycoprotein L	Family
E [auth B]	IPR038313	Herpesvirus glycoprotein L, rhadinovirus-type superfamily	Homologous Superfamily
E [auth B]	IPR020175	Herpesvirus glycoprotein L, rhadinovirus-type	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.