Annotations: 8JYA

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.120.920	Mainly Beta	Sandwich	Jelly Rolls	SPRY domain	CATH (utative)
B	2.60.120.920	Mainly Beta	Sandwich	Jelly Rolls	SPRY domain	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00622	SPRY domain (SPRY)	SPRY domain	-	Family
A, B	PF13765	SPRY-associated domain (PRY)	SPRY-associated domain	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Butyrophylin 3	protein binding binding signaling receptor binding	cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process cellular response to stimulus immune response-regulating cell surface receptor signaling pathway regulation of cellular process response to stimulus signaling positive regulation of biological process cell communication positive regulation of response to stimulus immune response-activating signaling pathway immune response-regulating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process regulation of biological process cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway immune response biological regulation T cell receptor signaling pathway regulation of response to stimulus immune system process regulation of immune response cellular process antigen receptor-mediated signaling pathway activation of immune response regulation of biosynthetic process multicellular organismal process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process regulation of cytokine production cytokine production regulation of macromolecule biosynthetic process metabolic process regulation of multicellular organismal process macromolecule metabolic process regulation of metabolic process	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
A, B	IPR001870	B30.2/SPRY domain	Domain
A, B	IPR006574	SPRY-associated	Domain
A, B	IPR003879	Butyrophylin-like, SPRY domain	Domain
A, B	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily
A, B	IPR053896	Butyrophilin subfamily 3 member A2-like, Ig-C domain	Domain
A, B	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A, B	IPR013106	Immunoglobulin V-set domain	Domain
A, B	IPR050504	Immunoglobulin superfamily BTN/MOG domain-containing protein	Family
A, B	IPR003599	Immunoglobulin domain subtype	Domain
A, B	IPR043136	B30.2/SPRY domain superfamily	Homologous Superfamily
A, B	IPR007110	Immunoglobulin-like domain	Domain
A, B	IPR037954	Butyrophilin subfamily 3, PRY/SPRY domain	Domain
A, B	IPR003877	SPRY domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.