Annotations: 8J0Q

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03299	Transcription factor AP-2 (TF_AP-2)	Transcription factor AP-2	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transcription factor AP-2-beta	sequence-specific DNA binding DNA binding binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding cis-regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity sequence-specific DNA binding DNA binding binding nucleic acid binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding cis-regulatory region sequence-specific DNA binding transcription regulatory region nucleic acid binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding protein heterodimerization activity protein binding protein dimerization activity identical protein binding protein homodimerization activity	response to stimulus response to chemical response to xenobiotic stimulus developmental process multicellular organismal process animal organ development renal system development multicellular organism development metanephros development anatomical structure development nephron development metanephric nephron development kidney development system development response to stimulus response to chemical response to xenobiotic stimulus developmental process multicellular organismal process animal organ development renal system development multicellular organism development metanephros development anatomical structure development nephron development metanephric nephron development kidney development system development regulation of biological process neuron apoptotic process positive regulation of programmed cell death regulation of cellular process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process cellular process apoptotic process positive regulation of neuron apoptotic process programmed cell death positive regulation of cellular process regulation of neuron apoptotic process sympathetic nervous system development autonomic nervous system development nervous system development monosaccharide metabolic process carbohydrate metabolic process hexose metabolic process small molecule metabolic process metabolic process primary metabolic process glucose metabolic process cellular response to stimulus cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction cell communication cellular response to endogenous stimulus signal transduction BMP signaling pathway enzyme-linked receptor protein signaling pathway cellular response to BMP stimulus regulation of signaling regulation of BMP signaling pathway cell surface receptor signaling pathway response to endogenous stimulus regulation of cellular response to growth factor stimulus response to BMP regulation of response to stimulus regulation of cell communication response to growth factor transforming growth factor beta receptor superfamily signaling pathway protein localization regulation of localization establishment of protein localization nitrogen compound transport localization cellular macromolecule localization regulation of biological quality regulation of peptide hormone secretion regulation of hormone levels establishment of protein localization to extracellular region protein secretion establishment of localization regulation of protein secretion regulation of secretion cellular localization regulation of hormone secretion regulation of protein localization regulation of peptide secretion transport hormone secretion protein localization to extracellular region peptide secretion regulation of secretion by cell secretion by cell amide transport signal release regulation of transport secretion regulation of peptide transport regulation of establishment of protein localization export from cell cell-cell signaling regulation of protein transport peptide transport protein transport regulation of cellular localization regulation of insulin secretion peptide hormone secretion macromolecule localization hormone transport insulin secretion fat cell differentiation cellular developmental process cell differentiation negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process blood vessel morphogenesis tube development artery development ductus arteriosus closure vasculature development circulatory system development anatomical structure morphogenesis tube morphogenesis artery morphogenesis blood vessel development aorta morphogenesis aorta development skin development negative regulation of programmed cell death negative regulation of apoptotic process collecting duct development negative regulation of neuron apoptotic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation negative regulation of cell population proliferation muscle tissue development smooth muscle tissue development tissue development retina layer formation camera-type eye morphogenesis sensory organ development eye development retina development in camera-type eye visual system development neural retina development retina morphogenesis in camera-type eye eye morphogenesis sensory organ morphogenesis camera-type eye development anatomical structure formation involved in morphogenesis animal organ morphogenesis sensory system development forelimb morphogenesis limb development appendage development appendage morphogenesis limb morphogenesis hindlimb morphogenesis epithelium development kidney epithelium development nephron tubule development distal tubule development renal tubule development nephron epithelium development regulation of developmental process regulation of cell differentiation	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004979	Transcription factor AP-2	Family
A, B	IPR013854	Transcription factor AP-2, C-terminal	Domain
A, B	IPR008122	Transcription factor AP-2 beta	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q92481	Char syndrome patent ductus arteriosus Craniofacial Abnormalities Sjogren syndrome breast cancer ductal breast carcinoma in situ malignant ependymoma polydactyly attention deficit hyperactivity disorder, inattentive type breast fibroadenoma metabolic syndrome X patent ductus arteriosus 2 psoriasis cutaneous lupus erythematosus intellectual disability Char syndrome patent ductus arteriosus Craniofacial Abnormalities Sjogren syndrome breast cancer ductal breast carcinoma in situ malignant ependymoma polydactyly attention deficit hyperactivity disorder, inattentive type breast fibroadenoma metabolic syndrome X patent ductus arteriosus 2 psoriasis cutaneous lupus erythematosus intellectual disability obesity disorder

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.