Annotations: 8J0L

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF03299	Transcription factor AP-2 (TF_AP-2)	Transcription factor AP-2	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Transcription factor AP-2-alpha	DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription repressor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding nucleic acid binding transcription regulatory region nucleic acid binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity identical protein binding protein binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process developmental process multicellular organismal process animal organ development multicellular organism development anatomical structure morphogenesis skeletal system development anatomical structure development skeletal system morphogenesis animal organ morphogenesis bone morphogenesis bone development system development limb development appendage development embryonic forelimb morphogenesis embryonic limb morphogenesis embryonic morphogenesis embryonic appendage morphogenesis embryo development forelimb morphogenesis appendage morphogenesis limb morphogenesis optic cup structural organization sensory organ development embryonic eye morphogenesis visual system development embryonic camera-type eye development eye morphogenesis embryonic organ development sensory system development embryonic organ morphogenesis camera-type eye morphogenesis morphogenesis of embryonic epithelium epithelium development eye development morphogenesis of an epithelium tissue development embryonic camera-type eye morphogenesis tissue morphogenesis sensory organ morphogenesis optic cup morphogenesis involved in camera-type eye development embryonic camera-type eye formation camera-type eye development anatomical structure formation involved in morphogenesis anatomical structure arrangement ear morphogenesis ear development inner ear development inner ear morphogenesis negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of gene expression positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process cellular response to stimulus cellular response to iron ion cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to iron ion response to chemical embryonic cranial skeleton morphogenesis chordate embryonic development embryo development ending in birth or egg hatching cranial skeletal system development embryonic skeletal system development embryonic skeletal system morphogenesis neuron apoptotic process positive regulation of programmed cell death positive regulation of apoptotic process positive regulation of neuron apoptotic process regulation of neuron apoptotic process regulation of multicellular organismal development regulation of developmental process tooth mineralization odontogenesis regulation of biomineral tissue development positive regulation of developmental process regulation of tooth mineralization positive regulation of biomineral tissue development positive regulation of tooth mineralization regulation of multicellular organismal process biomineral tissue development regulation of bone mineralization positive regulation of ossification ossification bone mineralization positive regulation of bone mineralization positive regulation of multicellular organismal process regulation of ossification cranial nerve formation cranial nerve morphogenesis parasympathetic nervous system development nervous system development nerve development oculomotor nerve formation cranial nerve development central nervous system development oculomotor nerve morphogenesis preganglionic parasympathetic fiber development oculomotor nerve development autonomic nervous system development trigeminal nerve development reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process negative regulation of transcription by competitive promoter binding negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus positive regulation of DNA-templated transcription positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process eyelid development in camera-type eye retina layer formation retina development in camera-type eye neural retina development retina morphogenesis in camera-type eye transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II kidney development renal system development positive regulation of transcription by RNA polymerase II roof of mouth development optic vesicle morphogenesis cellular developmental process cell differentiation regulation of cell differentiation	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membraneless organelle intracellular membraneless organelle chromatin chromosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR004979	Transcription factor AP-2	Family
A, B	IPR013854	Transcription factor AP-2, C-terminal	Domain
A, B	IPR008121	Transcription factor AP-2 alpha, N-terminal	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P05549	branchiooculofacial syndrome breast carcinoma branchio-oto-renal syndrome kidney disease Craniofacial Abnormalities breast cancer lung cancer malignant pancreatic neoplasm medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor polydactyly spina bifida cystic fibrosis intellectual disability branchiooculofacial syndrome breast carcinoma branchio-oto-renal syndrome kidney disease Craniofacial Abnormalities breast cancer lung cancer malignant pancreatic neoplasm medulloblastoma osteosarcoma atypical teratoid rhabdoid tumor polydactyly spina bifida cystic fibrosis intellectual disability malignant colon neoplasm non-small cell lung carcinoma ovarian cancer psoriasis branchiootorenal syndrome 2 cataract ductal breast carcinoma in situ interstitial cystitis lung adenocarcinoma oligodendroglioma pancreatic intraductal papillary-mucinous carcinoma schizophrenia coloboma cutaneous lupus erythematosus invasive ductal breast carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.