8EE8 | pdb_00008ee8

Crystal structure of a NHP anti-ZIKV neutralizing antibody rhMZ100-C in complex with ZIKV E glycoprotein

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: CATH
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth Z]	SCOP2B Superfamily	E set domains	8073018	3000070	SCOP2B (2022-06-29)
D [auth E]	SCOP2B Superfamily	E set domains	8073018	3000070	SCOP2B (2022-06-29)
E [auth B]	SCOP2B Superfamily	E set domains	8073018	3000070	SCOP2B (2022-06-29)
G [auth A]	SCOP2B Superfamily	E set domains	8073018	3000070	SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth Z]	2.60.40.350	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (utative)
D [auth E]	2.60.40.350	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (utative)
E [auth B]	2.60.40.350	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (utative)
G [auth A]	2.60.40.350	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (utative)
B [auth H]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
H [auth D]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
C [auth L]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)
F [auth C]	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (utative)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
B [auth H], H [auth D]	Heavy Chain	IGHV3	-	envelope protein e \| envelope protein e, envelope protein e	SAbDab (2025-03-21)
C [auth L], F [auth C]	Light Chain	IGLV11	Lambda	envelope protein e \| envelope protein e, envelope protein e	SAbDab (2025-03-21)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth Z], D [auth E], E [auth B], G [auth A]	PF00869	Flavivirus glycoprotein, central and dimerisation domains (Flavi_glycoprot)	Flavivirus glycoprotein, central and dimerisation domains		Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	PF02832	Flavivirus glycoprotein, immunoglobulin-like domain (Flavi_glycop_C)	Flavivirus glycoprotein, immunoglobulin-like domain		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth Z], D [auth E], E [auth B], G [auth A]	Envelope protein E	ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity ATP-dependent activity, acting on DNA catalytic activity, acting on DNA DNA translocase activity catalytic activity, acting on a nucleic acid chromatin extrusion motor activity catalytic activity ATP-dependent activity ATP-dependent H3-H4 histone complex chaperone activity catalytic activity, acting on a protein histone chaperone activity ATP-dependent chromatin remodeler activity H3-H4 histone complex chaperone activity protein carrier chaperone ATP-dependent histone chaperone activity molecular carrier activity RNA binding double-stranded RNA binding binding nucleic acid binding peptidase activity serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity endopeptidase activity iron-sulfur cluster binding 4 iron, 4 sulfur cluster binding metal cluster binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding molecular adaptor activity nucleic acid conformation isomerase activity isomerase activity catalytic activity, acting on RNA helicase activity RNA helicase activity ATP-dependent activity, acting on RNA macromolecular conformation isomerase activity protein binding protein dimerization activity cation binding metal ion binding RNA methyltransferase activity O-methyltransferase activity transferase activity, transferring one-carbon groups mRNA (nucleoside-2'-O-)-methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity methyltransferase activity mRNA methyltransferase activity RNA-directed RNA polymerase activity 5'-3' RNA polymerase activity RNA polymerase activity nucleotidyltransferase activity transferase activity, transferring phosphorus-containing groups cohesin loader activity mRNA 5'-cap (guanine-N7-)-methyltransferase activity N-methyltransferase activity DNA clamp loader activity ATP-dependent H2AZ histone chaperone activity guanyl nucleotide binding GTP binding guanyl ribonucleotide binding lipid binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides structural molecule activity	RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process cellular process macromolecule metabolic process symbiont-mediated perturbation of host cellular process biological process involved in interspecies interaction between organisms symbiont-mediated suppression of host JAK-STAT cascade biological process involved in interaction with host biological process involved in symbiotic interaction symbiont-mediated suppression of host signal transduction pathway symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT activity symbiont-mediated perturbation of host process symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT1 activity symbiont-mediated perturbation of host signal transduction pathway modulation of process of another organism symbiont-mediated perturbation of host autophagy symbiont-mediated activation of host autophagy symbiont-mediated suppression of host interferon-mediated signaling pathway symbiont-mediated suppression of host type I interferon-mediated signaling pathway fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell symbiont-mediated suppression of host JAK-STAT cascade via inhibition of STAT2 activity import into cell receptor-mediated endocytosis of virus by host cell transport establishment of localization vesicle-mediated transport localization symbiont entry into host cell clathrin-dependent endocytosis symbiont entry into host clathrin-dependent endocytosis of virus by host cell receptor-mediated endocytosis endocytosis endocytosis involved in viral entry into host cell regulation of defense response regulation of response to biotic stimulus negative regulation of response to biotic stimulus response to stimulus regulation of response to external stimulus negative regulation of biological process response to biotic stimulus response to stress regulation of response to stress innate immune response regulation of immune system process response to external biotic stimulus regulation of biological process negative regulation of response to stimulus immune response response to other organism defense response regulation of innate immune response negative regulation of immune response biological regulation defense response to symbiont response to external stimulus regulation of response to stimulus negative regulation of immune system process immune system process defense response to other organism negative regulation of response to external stimulus negative regulation of defense response regulation of immune response negative regulation of innate immune response virion attachment to host cell adhesion of symbiont to host cell adhesion of symbiont to host symbiont-mediated perturbation of host defense response symbiont-mediated perturbation of host immune response symbiont-mediated suppression of host immune response symbiont-mediated suppression of host innate immune response symbiont-mediated suppression of host JAK-STAT cascade via inhibition of host TYK2 activity symbiont-mediated perturbation of host innate immune response proteolysis protein metabolic process	cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum host cell membrane host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell endomembrane system host intracellular region host cell endoplasmic reticulum membrane cellular anatomical structure membrane host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum host cell membrane host cell cytoplasm part host intracellular organelle host cell cytoplasm host cell part host cell endomembrane system host intracellular region host cell endoplasmic reticulum membrane intracellular organelle centrosome microtubule organizing center intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle microtubule cytoskeleton viral capsid virion component host cell perinuclear region of cytoplasm virion membrane extracellular region host cell nucleus viral membrane viral envelope
B [auth H], H [auth D]	rhMZ100-C antibody heavy chain	-	-	-
C [auth L], F [auth C]	rhMZ100-C antibody light chain	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR000208	RNA-directed RNA polymerase, fingers/palm subdomains, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR001122	Capsid protein C, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR027287	Glycoprotein E, immunoglobulin-like domain, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR014412	Genome polyprotein, Flavivirus	Family
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR026490	mRNA cap 0/1 methyltransferase	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR001650	Helicase, C-terminal domain-like	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR013755	Flaviviral glycoprotein E, central domain, subdomain 1	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR000752	Flavivirus non-structural protein NS2A	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR047530	RNA-dependent RNA polymerase, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR049486	Flavivridae NS3 helicase, C-terminal helical domain	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR046811	RNA-directed RNA polymerase, thumb subdomain, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR002877	Ribosomal RNA methyltransferase, FtsJ domain	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR038302	Envelope glycoprotein M superfamily, flavivirus	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR000069	Envelope glycoprotein M, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR011492	Non-structural protein NS3-like, DEAD box helicase, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR038345	Flavivirus envelope glycoprotein E, Stem/Anchor domain superfamily	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR038688	Flavivirus polyprotein propeptide superfamily	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR029063	S-adenosyl-L-methionine-dependent methyltransferase superfamily	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR026470	Flavivirus envelope glycoprotein E, Stem/Anchor domain	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR011998	Envelope glycoprotein E, central and dimerisation domain, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR043502	DNA/RNA polymerase superfamily	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR037172	Flavivirus capsid protein C superfamily	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR000404	Flavivirus non-structural protein NS4A	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR000487	Non-structural protein NS2B, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR001528	Flavivirus non-structural protein NS4B	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR001157	Non-structural protein NS1, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR013756	Flaviviral glycoprotein E, central domain, subdomain 2	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR001850	Non-structural protein NS3, peptidase S7, flavivirus	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR002535	Flavivirus polyprotein propeptide	Domain
A [auth Z], D [auth E], E [auth B], G [auth A]	IPR007094	RNA-directed RNA polymerase, catalytic domain	Domain