Annotations: 8E3R

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth F]	PF00178	Ets-domain (Ets)	Ets-domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	DNA (5'-D(APAPTPAPAPAPAPGPGPAPAPGPTPGPGPG)-3')	-	-	-
B [auth D]	DNA (5'-D(TPCPCPCPAPCPTPTPCPCPTPTPTPTPAPT)-3')	-	-	-
C [auth F]	Transcription factor PU.1	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding STAT family protein binding DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding organic cyclic compound binding nucleic acid binding transcription regulatory region nucleic acid binding transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding DNA-binding transcription factor binding STAT family protein binding histone deacetylase binding enzyme binding transcription regulator activity DNA-binding transcription repressor activity DNA-binding transcription factor activity DNA-binding transcription factor activity, RNA polymerase II-specific cis-regulatory region sequence-specific DNA binding molecular adaptor activity RNA polymerase II transcription regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding chromatin binding NFAT protein binding DNA-binding transcription activator activity molecular sequestering activity protein sequestering activity RNA binding	response to tumor cell response to stimulus defense response response to stress defense response to tumor cell response to biotic stimulus regulation of cellular process positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process response to tumor cell response to stimulus defense response response to stress defense response to tumor cell response to biotic stimulus regulation of cellular process positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process positive regulation of gene expression, epigenetic cellular component organization RNA biosynthetic process nucleobase-containing compound metabolic process positive regulation of metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II positive regulation of biosynthetic process chromatin organization chromatin remodeling positive regulation of macromolecule metabolic process cellular component organization or biogenesis positive regulation of cellular process transcription initiation at RNA polymerase II promoter regulation of biosynthetic process regulation of biological process epigenetic regulation of gene expression biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation regulation of gene expression biosynthetic process positive regulation of gene expression transcription initiation-coupled chromatin remodeling regulation of macromolecule biosynthetic process metabolic process cellular process macromolecule metabolic process regulation of metabolic process developmental process multicellular organismal process cellular developmental process hemopoiesis cell activation cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation leukocyte activation T cell activation immune system process cell differentiation lymphoid progenitor cell differentiation anatomical structure development T cell differentiation pro-T cell differentiation leukocyte differentiation hematopoietic progenitor cell differentiation regulation of cell adhesion negative regulation of biological process cell morphogenesis negative regulation of cell adhesion endothelial to hematopoietic transition anatomical structure morphogenesis cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion delamination positive regulation of DNA-templated transcription positive regulation of miRNA transcription positive regulation of miRNA metabolic process regulation of primary metabolic process regulation of RNA metabolic process miRNA transcription regulation of miRNA metabolic process regulation of nucleobase-containing compound metabolic process miRNA metabolic process regulation of RNA biosynthetic process positive regulation of nucleobase-containing compound metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of miRNA transcription regulation of developmental process homeostatic process regulation of cell differentiation regulation of cell development multicellular organism development regulation of immune system process regulation of multicellular organismal process myeloid cell homeostasis erythrocyte homeostasis regulation of multicellular organismal development regulation of myeloid cell differentiation erythrocyte differentiation regulation of erythrocyte differentiation multicellular organismal-level homeostasis myeloid cell differentiation regulation of hemopoiesis homeostasis of number of cells negative regulation of adipose tissue development connective tissue development adipose tissue development negative regulation of developmental process animal organ development tissue development regulation of adipose tissue development negative regulation of multicellular organismal process regulation of myeloid progenitor cell differentiation myeloid progenitor cell differentiation regulation of hematopoietic progenitor cell differentiation regulation of defense response regulation of response to biotic stimulus positive regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus positive regulation of antifungal innate immune response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of immune response regulation of response to stress innate immune response regulation of antifungal innate immune response response to external biotic stimulus positive regulation of immune system process antifungal innate immune response positive regulation of innate immune response immune response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus defense response to fungus regulation of defense response to fungus regulation of response to stimulus defense response to other organism positive regulation of defense response regulation of immune response response to fungus myeloid leukocyte differentiation negative regulation of RNA biosynthetic process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of transcription by RNA polymerase II negative regulation of DNA-templated transcription negative regulation of transcription by RNA polymerase II negative regulation of metabolic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process regulation of leukocyte differentiation regulation of leukocyte activation regulation of cell activation positive regulation of B cell differentiation positive regulation of developmental process positive regulation of cell activation positive regulation of leukocyte activation positive regulation of cell development positive regulation of multicellular organismal process positive regulation of lymphocyte activation regulation of B cell differentiation B cell differentiation positive regulation of hemopoiesis positive regulation of cell differentiation regulation of B cell activation regulation of lymphocyte differentiation B cell activation positive regulation of B cell activation positive regulation of leukocyte differentiation positive regulation of lymphocyte differentiation regulation of lymphocyte activation positive regulation of transcription by RNA polymerase II regulation of immune effector process neutrophil activation regulation of localization regulation of myeloid leukocyte mediated immunity regulated exocytosis negative regulation of transport cell activation involved in immune response leukocyte degranulation myeloid leukocyte mediated immunity vesicle-mediated transport myeloid leukocyte activation localization neutrophil activation involved in immune response negative regulation of secretion establishment of localization in cell leukocyte mediated immunity negative regulation of secretion by cell negative regulation of myeloid leukocyte mediated immunity negative regulation of immune response negative regulation of immune effector process establishment of localization immune effector process regulation of secretion regulation of leukocyte mediated immunity exocytosis cellular localization transport negative regulation of neutrophil degranulation negative regulation of regulated secretory pathway negative regulation of leukocyte degranulation regulation of regulated secretory pathway neutrophil mediated immunity secretion by cell regulation of secretion by cell negative regulation of exocytosis regulation of neutrophil degranulation leukocyte activation involved in immune response neutrophil degranulation regulation of leukocyte degranulation secretion regulation of transport negative regulation of response to stimulus export from cell regulation of vesicle-mediated transport myeloid cell activation involved in immune response negative regulation of immune system process regulation of exocytosis negative regulation of leukocyte mediated immunity granulocyte activation regulation of molecular function regulation of DNA-binding transcription factor activity pericyte cell differentiation microglial cell mediated cytotoxicity positive regulation of leukocyte mediated immunity positive regulation of leukocyte mediated cytotoxicity positive regulation of immune effector process regulation of leukocyte mediated cytotoxicity positive regulation of microglial cell mediated cytotoxicity leukocyte mediated cytotoxicity positive regulation of myeloid leukocyte mediated immunity regulation of cell killing positive regulation of cell killing regulation of microglial cell mediated cytotoxicity cell killing negative regulation of DNA-binding transcription factor activity negative regulation of NF-kappaB transcription factor activity negative regulation of molecular function protein localization protein localization to chromatin regulation of protein localization negative regulation of protein localization to chromatin protein localization to chromosome regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle regulation of protein localization to chromatin negative regulation of protein localization interleukin-6-mediated signaling pathway cellular response to stimulus response to interleukin-6 cell surface receptor signaling pathway signaling cellular response to interleukin-6 response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus signal transduction cellular response to stress cellular senescence oncogene-induced cell senescence positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction p38MAPK cascade intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade positive regulation of p38MAPK cascade regulation of p38MAPK cascade MAPK cascade regulation of cell communication positive regulation of signaling negative regulation of gene expression negative regulation of signaling negative regulation of intracellular signal transduction regulation of non-canonical NF-kappaB signal transduction negative regulation of cell communication negative regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction negative regulation of signal transduction extrinsic apoptotic signaling pathway via death domain receptors cell death extrinsic apoptotic signaling pathway apoptotic signaling pathway TRAIL-activated apoptotic signaling pathway apoptotic process programmed cell death	protein-containing complex transcription regulator complex intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle protein-containing complex transcription regulator complex intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromatin chromosome membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth F]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
C [auth F]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
C [auth F]	IPR000418	Ets domain	Domain
C [auth F]	IPR046328	ETS family	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C [auth F]	Pharos: P17947	acute myeloid leukemia myeloid leukemia cancer chronic monocytic leukemia Precursor T-Cell Lymphoblastic Leukemia-Lymphoma endogenous depression lung carcinoma open-angle glaucoma prostate carcinoma salmonellosis cerebrovascular disorder hematologic disease osteosarcoma psoriasis typhoid fever acute myeloid leukemia myeloid leukemia cancer chronic monocytic leukemia Precursor T-Cell Lymphoblastic Leukemia-Lymphoma endogenous depression lung carcinoma open-angle glaucoma prostate carcinoma salmonellosis cerebrovascular disorder hematologic disease osteosarcoma psoriasis typhoid fever hypertensive disorder non-small cell lung carcinoma rheumatoid arthritis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.