Annotations: 8BB8

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	ALDH-like	8076887	3001479	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	ALDH-like	8076887	3001479	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	F_UNCLASSIFIED	e8bb8B1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: F_UNCLASSIFIED	ECOD (1.6)
A	F_UNCLASSIFIED	e8bb8A1	A: a/b three-layered sandwiches	X: ALDH-like (From Topology)	H: ALDH-like (From Topology)	T: ALDH-like	F: F_UNCLASSIFIED	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF05893	Acyl-CoA reductase (LuxC) (LuxC)	Acyl-CoA reductase (LuxC)	-	Family
A, B	PF00171	Aldehyde dehydrogenase family (Aldedh)	Aldehyde dehydrogenase family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Aldehyde dehydrogenase, dimeric NADP-preferring	oxidoreductase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity aldehyde dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor aldo-keto reductase (NADPH) activity alcohol dehydrogenase [NAD(P)+] activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors alcohol dehydrogenase (NADP+) activity benzaldehyde dehydrogenase (NAD+) activity aldehyde dehydrogenase (NAD+) activity benzaldehyde dehydrogenase [NAD(P)+] activity 3-chloroallyl aldehyde dehydrogenase activity	cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus metabolic process cellular process xenobiotic metabolic process response to xenobiotic stimulus aldehyde metabolic process primary metabolic process lipid metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane extracellular region extracellular space membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum intracellular membrane-bounded organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane extracellular region extracellular space membrane-bounded organelle intracellular organelle organelle endoplasmic reticulum intracellular membrane-bounded organelle endomembrane system

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012394	Aldehyde dehydrogenase NAD(P)-dependent	Family
A, B	IPR015590	Aldehyde dehydrogenase domain	Domain
A, B	IPR016161	Aldehyde/histidinol dehydrogenase	Homologous Superfamily
A, B	IPR016162	Aldehyde dehydrogenase, N-terminal	Homologous Superfamily
A, B	IPR029510	Aldehyde dehydrogenase, glutamic acid active site	Conserved Site
A, B	IPR016163	Aldehyde dehydrogenase, C-terminal	Homologous Superfamily
A, B	IPR016160	Aldehyde dehydrogenase, cysteine active site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P30838	cataract Corneal Scar head and neck cancer pancreatic intraductal papillary-mucinous neoplasm schizophrenia chronic obstructive pulmonary disease Crohn disease nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia esophageal adenocarcinoma interstitial cystitis non-small cell lung carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.