Annotations: 7ZD5

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	1.20.1560.10	Mainly Alpha	Up-down Bundle	ABC transporter transmembrane region fold	ABC transporter type 1, transmembrane domain	CATH (utative)
A [auth C]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
B [auth D]	1.20.1560.10	Mainly Alpha	Up-down Bundle	ABC transporter transmembrane region fold	ABC transporter type 1, transmembrane domain	CATH (utative)
B [auth D]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF00664	ABC transporter transmembrane region (ABC_membrane)	ABC transporter transmembrane region	-	Family
A [auth C]	PF00005	ABC transporter (ABC_tran)	ABC transporter	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	Domain
B [auth D]	PF00664	ABC transporter transmembrane region (ABC_membrane)	ABC transporter transmembrane region	-	Family
B [auth D]	PF00005	ABC transporter (ABC_tran)	ABC transporter	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are comp ...	ABC transporters for a large family of proteins responsible for translocation of a variety of compounds across biological membranes. ABC transporters are the largest family of proteins in many completely sequenced bacteria. ABC transporters are composed of two copies of this domain and two copies of a transmembrane domain Pfam:PF00664. These four domains may belong to a single polypeptide as in Swiss:P13569, or belong in different polypeptide chains.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	ATP-binding/permease protein CydC	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ABC-type transporter activity active transmembrane transporter activity heme transmembrane transporter activity ABC-type heme transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity transporter activity transmembrane transporter activity ATP-dependent activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	biosynthetic process cytochrome biosynthetic process cytochrome metabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process cell redox homeostasis cellular homeostasis homeostatic process nitrogen compound transport organic anion transport biosynthetic process cytochrome biosynthetic process cytochrome metabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process cell redox homeostasis cellular homeostasis homeostatic process nitrogen compound transport organic anion transport transport oligopeptide transport glutathione transport establishment of localization tripeptide transmembrane transport glutathione transmembrane transport peptide transport transmembrane transport oligopeptide transmembrane transport localization tripeptide transport amide transport sulfur compound transport modified amino acid transport carboxylic acid transmembrane transport amino acid transmembrane transport export across plasma membrane sulfur amino acid transport organic acid transmembrane transport carboxylic acid transport export from cell neutral amino acid transport organic cation transport organic acid transport amino acid transport cysteine transport amino acid export across plasma membrane cysteine export across plasma membrane cysteine transmembrane transport heme transmembrane transport monoatomic ion transmembrane transport iron ion transport iron ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport monoatomic cation transmembrane transport heme transport transition metal ion transport monoatomic ion transport monoatomic cation transport iron coordination entity transport	ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex transporter complex ATP-binding cassette (ABC) transporter complex cell periphery cellular anatomical structure transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, integrated substrate binding
B [auth D]	ATP-binding/permease protein CydD	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding lipid transporter activity active transmembrane transporter activity lipid transmembrane transporter activity ATPase-coupled lipid transmembrane transporter activity primary active transmembrane transporter activity ATPase-coupled transmembrane transporter activity transporter activity transmembrane transporter activity ATP-dependent activity ABC-type transporter activity heme transmembrane transporter activity ABC-type heme transporter activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	biosynthetic process cytochrome biosynthetic process cytochrome metabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process cell redox homeostasis cellular homeostasis homeostatic process nitrogen compound transport organic anion transport biosynthetic process cytochrome biosynthetic process cytochrome metabolic process metabolic process cellular process primary metabolic process macromolecule metabolic process protein metabolic process macromolecule biosynthetic process cell redox homeostasis cellular homeostasis homeostatic process nitrogen compound transport organic anion transport transport oligopeptide transport glutathione transport establishment of localization tripeptide transmembrane transport glutathione transmembrane transport peptide transport transmembrane transport oligopeptide transmembrane transport localization tripeptide transport amide transport sulfur compound transport modified amino acid transport carboxylic acid transmembrane transport amino acid transmembrane transport export across plasma membrane sulfur amino acid transport organic acid transmembrane transport carboxylic acid transport export from cell neutral amino acid transport organic cation transport organic acid transport amino acid transport cysteine transport amino acid export across plasma membrane cysteine export across plasma membrane cysteine transmembrane transport heme transmembrane transport monoatomic ion transmembrane transport iron ion transport iron ion transmembrane transport inorganic ion transmembrane transport metal ion transport inorganic cation transmembrane transport monoatomic cation transmembrane transport heme transport transition metal ion transport monoatomic ion transport monoatomic cation transport iron coordination entity transport	ATPase dependent transmembrane transport complex protein-containing complex plasma membrane protein complex membrane plasma membrane membrane protein complex transporter complex ATP-binding cassette (ABC) transporter complex cell periphery cellular anatomical structure transmembrane transporter complex ATP-binding cassette (ABC) transporter complex, integrated substrate binding

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR017871	ABC transporter-like, conserved site	Conserved Site
A [auth C]	IPR003439	ABC transporter-like, ATP-binding domain	Domain
A [auth C]	IPR036640	ABC transporter type 1, transmembrane domain superfamily	Homologous Superfamily
A [auth C]	IPR003593	AAA+ ATPase domain	Domain
A [auth C]	IPR014223	Glutathione/L-cysteine transport system ATP-binding/permease protein CydC/D	Family
A [auth C]	IPR011527	ABC transporter type 1, transmembrane domain	Domain
A [auth C]	IPR039421	Type 1 protein exporter	Family
A [auth C]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
B [auth D]	IPR017871	ABC transporter-like, conserved site	Conserved Site
B [auth D]	IPR003439	ABC transporter-like, ATP-binding domain	Domain
B [auth D]	IPR036640	ABC transporter type 1, transmembrane domain superfamily	Homologous Superfamily
B [auth D]	IPR003593	AAA+ ATPase domain	Domain
B [auth D]	IPR011527	ABC transporter type 1, transmembrane domain	Domain
B [auth D]	IPR039421	Type 1 protein exporter	Family
B [auth D]	IPR014216	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease/ATP-binding protein CydD	Family
B [auth D]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Membrane Protein Annotation: OPM OPM Database Homepage

Chains	External Link	Type	Class	Superfamily	Family
A [auth C], B [auth D]	OPM	Transmembrane	Alpha-helical polytopic	ABC transporters	Multidrug resistance exporter (MDR)

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

Chains	External Link	Comment
A [auth C], B [auth D]	PDBTM	Annotated as membrane protein by PDBTM

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.