7WF3 | pdb_00007wf3

Composite map of human Kv1.3 channel in apo state with beta subunits

External Resource: Annotation


Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
J [auth N]SCOP2B SuperfamilyPOZ domain 8067483 3000894 SCOP2B (2022-06-29)
K [auth O]SCOP2B SuperfamilyPOZ domain 8067483 3000894 SCOP2B (2022-06-29)
L [auth P]SCOP2B SuperfamilyPOZ domain 8067483 3000894 SCOP2B (2022-06-29)
H [auth J]SCOP2B SuperfamilyPOZ domain 8067483 3000894 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
B [auth C]Aldo_ket_rede7wf3C1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Aldo_ket_redECOD (1.6)
E [auth G]Aldo_ket_rede7wf3G1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Aldo_ket_redECOD (1.6)
G [auth I]Aldo_ket_rede7wf3I1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Aldo_ket_redECOD (1.6)
I [auth M]Aldo_ket_rede7wf3M1 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Aldo_ket_redECOD (1.6)
J [auth N]BTB_2e7wf3N1 A: a+b two layersX: POZ domain (From Topology)H: POZ domain (From Topology)T: POZ domainF: BTB_2ECOD (1.6)
K [auth O]BTB_2e7wf3O1 A: a+b two layersX: POZ domain (From Topology)H: POZ domain (From Topology)T: POZ domainF: BTB_2ECOD (1.6)
L [auth P]BTB_2e7wf3P1 A: a+b two layersX: POZ domain (From Topology)H: POZ domain (From Topology)T: POZ domainF: BTB_2ECOD (1.6)
H [auth J]BTB_2e7wf3J1 A: a+b two layersX: POZ domain (From Topology)H: POZ domain (From Topology)T: POZ domainF: BTB_2ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth B]1.20.120.350 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) Voltage-gated potassium channels. Chain CCATH (utative)
A [auth B]1.10.287.70 Mainly Alpha Orthogonal Bundle Helix Hairpins CATH (utative)
C [auth D]1.20.120.350 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) Voltage-gated potassium channels. Chain CCATH (utative)
C [auth D]1.10.287.70 Mainly Alpha Orthogonal Bundle Helix Hairpins CATH (utative)
F [auth H]1.20.120.350 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) Voltage-gated potassium channels. Chain CCATH (utative)
F [auth H]1.10.287.70 Mainly Alpha Orthogonal Bundle Helix Hairpins CATH (utative)
D [auth F]1.20.120.350 Mainly Alpha Up-down Bundle Four Helix Bundle (Hemerythrin (Met), subunit A) Voltage-gated potassium channels. Chain CCATH (utative)
D [auth F]1.10.287.70 Mainly Alpha Orthogonal Bundle Helix Hairpins CATH (utative)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A [auth B],
C [auth D],
D [auth F],
F [auth H]		PF07885Ion channel (Ion_trans_2)Ion channel- Family
A [auth B],
C [auth D],
D [auth F],
F [auth H]		PF00520Ion transport protein (Ion_trans)Ion transport protein- Family
B [auth C],
E [auth G],
G [auth I],
I [auth M]		PF00248Aldo/keto reductase family (Aldo_ket_red)Aldo/keto reductase familyThis family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity [2]. Domain
H [auth J],
J [auth N],
K [auth O],
L [auth P]		PF02214BTB/POZ domain (BTB_2)BTB/POZ domainIn voltage-gated K+ channels this domain is responsible for subfamily-specific assembly of alpha-subunits into functional tetrameric channels [1]. In KCTD1 (Swiss:Q719H9) this domain functions as a transcriptional repressor [2]. It also mediates homo ...Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A [auth B],
C [auth D],
D [auth F],
F [auth H]		Potassium voltage-gated channel subfamily A member 3
B [auth C],
E [auth G],
G [auth I],
I [auth M]		Voltage-gated potassium channel subunit beta-2
H [auth J],
J [auth N],
K [auth O],
L [auth P]		Potassium voltage-gated channel subfamily A member 3

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR003972Potassium channel, voltage dependent, Kv1Family
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR004050Potassium channel, voltage dependent, Kv1.3Family
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR028325Voltage-gated potassium channelFamily
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR000210BTB/POZ domainDomain
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR003968Potassium channel, voltage dependent, KvFamily
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR005821Ion transport domainDomain
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR003131Potassium channel tetramerisation-type BTB domainDomain
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR011333SKP1/BTB/POZ domain superfamilyHomologous Superfamily
A [auth B],
C [auth D],
D [auth F],
F [auth H]		IPR027359Voltage-dependent channel domain superfamilyHomologous Superfamily
B [auth C],
E [auth G],
G [auth I],
I [auth M]		IPR005399Potassium channel, voltage-dependent, beta subunit, KCNAB-relatedFamily
B [auth C],
E [auth G],
G [auth I],
I [auth M]		IPR036812NADP-dependent oxidoreductase domain superfamilyHomologous Superfamily
B [auth C],
E [auth G],
G [auth I],
I [auth M]		IPR005401Potassium channel, voltage-dependent, beta subunit, KCNAB2Family
B [auth C],
E [auth G],
G [auth I],
I [auth M]		IPR023210NADP-dependent oxidoreductase domainDomain
B [auth C],
E [auth G],
G [auth I],
I [auth M]		IPR005983Potassium channel, voltage-dependent, beta subunit, KCNABFamily
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR003972Potassium channel, voltage dependent, Kv1Family
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR004050Potassium channel, voltage dependent, Kv1.3Family
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR028325Voltage-gated potassium channelFamily
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR000210BTB/POZ domainDomain
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR003968Potassium channel, voltage dependent, KvFamily
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR005821Ion transport domainDomain
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR003131Potassium channel tetramerisation-type BTB domainDomain
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR011333SKP1/BTB/POZ domain superfamilyHomologous Superfamily
H [auth J],
J [auth N],
K [auth O],
L [auth P]		IPR027359Voltage-dependent channel domain superfamilyHomologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A [auth B],
C [auth D],
D [auth F],
F [auth H]		Pharos:  P22001
B [auth C],
E [auth G],
G [auth I],
I [auth M]		Pharos:  Q13303
H [auth J],
J [auth N],
K [auth O],
L [auth P]		Pharos:  P22001

Membrane Protein Annotation: OPM OPM Database Homepage

ChainsExternal LinkTypeClassSuperfamilyFamily
OPMTransmembraneAlpha-helical polytopicIon channel (VIC) superfamilyKvAP voltage-regulated K channels

Membrane Protein Annotation: PDBTM PDBTM Database Homepage

ChainsExternal LinkComment
PDBTMAnnotated as membrane protein by PDBTM

Membrane Protein Annotation: MemProtMD MemProtMD Database Homepage

ChainsExternal LinkComment
MemProtMDAnnotated as membrane protein by MemProtMD

Membrane Protein Annotation: mpstruc mpstruc Database Homepage

ChainsResource LinkGroupSubgroupProtein
mpstrucTRANSMEMBRANE PROTEINS: ALPHA-HELICALChannels: Potassium, Sodium, & Proton Ion-SelectiveKv1.3 lymphocyte Voltage-gated potassium Channel with beta subunits, apo state