7UPA | pdb_00007upa

Prefusion-stabilized Nipah virus fusion protein complexed with Fab 1H8

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth A]	SCOP2B Superfamily	Virus ectodomain	8072297	3001628	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Virus ectodomain	8072297	3001628	SCOP2B (2022-06-29)
E [auth G]	SCOP2B Superfamily	Virus ectodomain	8072297	3001628	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth H]	F_UNCLASSIFIED	e7upaH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
F [auth B]	F_UNCLASSIFIED	e7upaB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
H [auth C]	F_UNCLASSIFIED	e7upaC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
B [auth L]	F_UNCLASSIFIED	e7upaL1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
G [auth E]	F_UNCLASSIFIED	e7upaE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
I [auth F]	F_UNCLASSIFIED	e7upaF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth A]	F_UNCLASSIFIED	e7upaA2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-like domain in paramyxoviruses fusion protein (From Topology)	T: Immunoglobulin-like domain in paramyxoviruses fusion protein	F: F_UNCLASSIFIED	ECOD (1.6)
C [auth A]	F_UNCLASSIFIED	e7upaA1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7upaD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-like domain in paramyxoviruses fusion protein (From Topology)	T: Immunoglobulin-like domain in paramyxoviruses fusion protein	F: F_UNCLASSIFIED	ECOD (1.6)
D	F_UNCLASSIFIED	e7upaD1	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth G]	F_UNCLASSIFIED	e7upaG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-like domain in paramyxoviruses fusion protein (From Topology)	T: Immunoglobulin-like domain in paramyxoviruses fusion protein	F: F_UNCLASSIFIED	ECOD (1.6)
E [auth G]	F_UNCLASSIFIED	e7upaG2	A: a+b complex topology	X: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	H: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein (From Topology)	T: Head and neck region of the ectodomain of paramyxoviruses fusion glycoprotein	F: F_UNCLASSIFIED	ECOD (1.6)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
A [auth H], F [auth B], H [auth C]	Heavy Chain	IGHV1	-	fusion glycoprotein f0	SAbDab (2025-04-04)
B [auth L], G [auth E], I [auth F]	Light Chain	IGKV10	Kappa	fusion glycoprotein f0	SAbDab (2025-04-04)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C [auth A], D, E [auth G]	PF00523	Fusion glycoprotein F0 (Fusion_gly)	Fusion glycoprotein F0	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth H], F [auth B], H [auth C]	Fab 1H8 heavy chain	-	-	-
B [auth L], G [auth E], I [auth F]	Fab 1H8 light chain	-	-	-
C [auth A], D, E [auth G]	Fusion glycoprotein F0	-	membrane organization cellular component organization membrane fusion fusion of virus membrane with host plasma membrane viral process cellular process cellular component organization or biogenesis membrane fusion involved in viral entry into host cell biological process involved in interspecies interaction between organisms symbiont entry into host cell symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction	virion component viral membrane viral envelope cellular anatomical structure membrane host cell plasma membrane host cellular component host cell part host cell membrane virion membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C [auth A], D, E [auth G]	IPR000776	Precursor fusion glycoprotein F0, Paramyxoviridae	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.