7QLQ

CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT N151G, L259V COMPLEXED WITH FE, NAD, AND DIMETHOXYPHENYL ACETAMIDE

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth BBB]	SCOP2B Superfamily	Dehydroquinate synthase-like	8038927	3001905	SCOP2B (2022-06-29)
A [auth AAA]	SCOP2B Superfamily	Dehydroquinate synthase-like	8038927	3001905	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth BBB]	Fe-ADH_C	e7qlqBBB2	A: alpha bundles	X: alpha-helical domain in dehydroquinate synthase-like enzymes (From Topology)	H: alpha-helical domain in dehydroquinate synthase-like enzymes (From Topology)	T: alpha-helical domain in dehydroquinate synthase-like enzymes	F: Fe-ADH_C	ECOD (1.6)
B [auth BBB]	Fe-ADH_N	e7qlqBBB1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Rossmann-like domain in dehydroquinate synthase-like enzymes	F: Fe-ADH_N	ECOD (1.6)
A [auth AAA]	Fe-ADH_C	e7qlqAAA2	A: alpha bundles	X: alpha-helical domain in dehydroquinate synthase-like enzymes (From Topology)	H: alpha-helical domain in dehydroquinate synthase-like enzymes (From Topology)	T: alpha-helical domain in dehydroquinate synthase-like enzymes	F: Fe-ADH_C	ECOD (1.6)
A [auth AAA]	Fe-ADH_N	e7qlqAAA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Class I glutamine amidotransferase-like	T: Rossmann-like domain in dehydroquinate synthase-like enzymes	F: Fe-ADH_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA], B [auth BBB]	PF00465	Iron-containing alcohol dehydrogenase (Fe-ADH)	Iron-containing alcohol dehydrogenase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA], B [auth BBB]	Lactaldehyde reductase	oxidoreductase activity lactaldehyde reductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors R-lactaldehyde reductase activity catalytic activity cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding oxidoreductase activity lactaldehyde reductase activity oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor oxidoreductase activity, acting on CH-OH group of donors R-lactaldehyde reductase activity catalytic activity cation binding transition metal ion binding iron ion binding ion binding binding ferrous iron binding metal ion binding small molecule binding identical protein binding protein binding protein homodimerization activity protein dimerization activity nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding S-lactaldehyde reductase activity alcohol dehydrogenase [NAD(P)+] activity alcohol dehydrogenase (NAD+) activity	polyol metabolic process diol metabolic process propanediol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular process glycol metabolic process diol catabolic process alcohol catabolic process catabolic process polyol catabolic process organic hydroxy compound catabolic process polyol metabolic process diol metabolic process propanediol metabolic process organic hydroxy compound metabolic process alcohol metabolic process small molecule metabolic process metabolic process cellular process glycol metabolic process diol catabolic process alcohol catabolic process catabolic process polyol catabolic process organic hydroxy compound catabolic process glycol catabolic process small molecule catabolic process monosaccharide metabolic process carbohydrate metabolic process hexose catabolic process carbohydrate catabolic process hexose metabolic process primary metabolic process fucose metabolic process L-fucose metabolic process fucose catabolic process L-fucose catabolic process monosaccharide catabolic process rhamnose catabolic process rhamnose metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA], B [auth BBB]	IPR001670	Alcohol dehydrogenase, iron-type/glycerol dehydrogenase GldA	Domain
A [auth AAA], B [auth BBB]	IPR013460	Lactaldehyde reductase	Family
A [auth AAA], B [auth BBB]	IPR039697	Iron-type alcohol dehydrogenase-like	Family
A [auth AAA], B [auth BBB]	IPR018211	Alcohol dehydrogenase, iron-type, conserved site	Conserved Site

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.