7PKS | pdb_00007pks

Structural basis of Integrator-mediated transcription regulation

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
J	SCOP2B Superfamily	RNA polymerase subunit RPB10	8105377	3001213	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	RBP11-like subunits of RNA polymerase	8080728	3001655	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	RNA polymerase subunits	8103068	3001823	SCOP2B (2022-06-29)
Q [auth U]	SCOP2B Superfamily	MgtE/FliG domain-like	8102749	3000127	SCOP2B (2022-06-29)
S [auth W]	SCOP2B Superfamily	ARM repeat-like	8102747	3000116	SCOP2B (2022-06-29)
U [auth Z]	SCOP2B Superfamily	Translation proteins SH3-like KOW motif containing domain	8039849	3000334	SCOP2B (2022-06-29)
EA [auth p]	SCOP2B Superfamily	ARM repeat-like	8038568	3000116	SCOP2B (2022-06-29)
FA [auth q]	SCOP2B Superfamily	Metallo-dependent phosphatases	8039778	3001067	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	HRDC-like	8101241	3000132	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	RPB6/omega subunit-like	8106082	3000189	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	RNA_pol_Rpb1_2	e7pksA3	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RNA_pol_Rpb1_2	ECOD (1.6)
A	RNA_pol_Rpb1_2_1	e7pksA6	A: a+b two layers	X: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase (From Topology)	H: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase (From Topology)	T: MoeA-I/Ornithine decarboxylase-C/Reverse ferredoxin-like domain in RNA-polymerase	F: RNA_pol_Rpb1_2_1	ECOD (1.6)
A	RNA_pol_Rpb1_7	e7pksA7	A: a+b two layers	X: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)	H: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)	T: permuted ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_7	ECOD (1.6)
A	RNAP_II_Rpb1_C	e7pksA9	A: a+b two layers	X: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)	H: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit (From Topology)	T: ferredoxin-like domain in yeast RNA-polymerase beta-prime subunit	F: RNAP_II_Rpb1_C	ECOD (1.6)
A	RNA_pol_Rpb1_1	e7pksA1	A: a+b complex topology	X: N-terminal domain in RNA-polymerase beta-prime subunit (From Topology)	H: N-terminal domain in RNA-polymerase beta-prime subunit (From Topology)	T: N-terminal domain in RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_1	ECOD (1.6)
A	RNA_pol_Rpb1_5_3rd	e7pksA8	A: a+b complex topology	X: central helical domain in RNA-polymerase beta-prime subunit (From Topology)	H: central helical domain in RNA-polymerase beta-prime subunit (From Topology)	T: central helical domain in RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_5_3rd	ECOD (1.6)
A	RNA_pol_Rpb1_6	e7pksA5	A: a+b complex topology	X: helical domain in yeast RNA-polymerases	H: third helical domain in yeast RNA-polymerase II beta-prime subunit (From Topology)	T: third helical domain in yeast RNA-polymerase II beta-prime subunit	F: RNA_pol_Rpb1_6	ECOD (1.6)
A	RNA_pol_Rpb1_4	e7pksA2	A: a+b complex topology	X: second helical domain in RNA-polymerase beta-prime subunit (From Topology)	H: second helical domain in RNA-polymerase beta-prime subunit (From Topology)	T: second helical domain in RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_4	ECOD (1.6)
A	RNA_pol_Rpb1_3	e7pksA4	A: a+b complex topology	X: first helical domain in RNA-polymerase beta-prime subunit (From Topology)	H: first helical domain in RNA-polymerase beta-prime subunit (From Topology)	T: first helical domain in RNA-polymerase beta-prime subunit	F: RNA_pol_Rpb1_3	ECOD (1.6)
J	RNA_pol_N	e7pksJ1	A: alpha arrays	X: HTH	H: RPB10 (From Topology)	T: RPB10	F: RNA_pol_N	ECOD (1.6)
K	RNA_pol_L_2	e7pksK1	A: a+b two layers	X: DCoH-like	H: RBP11-like subunits of RNA polymerase (From Topology)	T: RBP11-like subunits of RNA polymerase	F: RNA_pol_L_2	ECOD (1.6)
L	DNA_RNApol_7kD	e7pksL1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: DNA_RNApol_7kD	ECOD (1.6)
B	RNA_pol_Rpb2_6_3rd_2	e7pksB2	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: double psi	F: RNA_pol_Rpb2_6_3rd_2	ECOD (1.6)
B	RNA_pol_Rpb2_6_2nd_1	e7pksB7	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: Single hybrid motif	F: RNA_pol_Rpb2_6_2nd_1	ECOD (1.6)
B	RNA_pol_Rpb2_3	e7pksB1	A: a+b complex topology	X: N-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	H: N-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	T: N-terminal domain in beta subunit of DNA dependent RNA-polymerase	F: RNA_pol_Rpb2_3	ECOD (1.6)
B	RNA_pol_Rpb2_1	e7pksB5	A: a+b complex topology	X: insertion domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	H: insertion domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	T: insertion domain in beta subunit of DNA dependent RNA-polymerase	F: RNA_pol_Rpb2_1	ECOD (1.6)
B	RNA_pol_Rpb2_45_1	e7pksB4	A: a+b complex topology	X: barrel domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	H: barrel domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	T: barrel domain in beta subunit of DNA dependent RNA-polymerase	F: RNA_pol_Rpb2_45_1	ECOD (1.6)
B	RNA_pol_Rpb2_7	e7pksB3	A: a+b complex topology	X: C-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	H: C-terminal domain in beta subunit of DNA dependent RNA-polymerase (From Topology)	T: C-terminal domain in beta subunit of DNA dependent RNA-polymerase	F: RNA_pol_Rpb2_7	ECOD (1.6)
B	RNA_pol_Rpb2_4	e7pksB6	A: a+b complex topology	X: inserted a+b domain in yeast RNA polymerase beta subunit (From Topology)	H: inserted a+b domain in yeast RNA polymerase beta subunit (From Topology)	T: inserted a+b domain in yeast RNA polymerase beta subunit	F: RNA_pol_Rpb2_4	ECOD (1.6)
U [auth Z]	F_UNCLASSIFIED	e7pksZ5	A: beta barrels	X: SH3	H: SH3	T: SH3	F: F_UNCLASSIFIED	ECOD (1.6)
U [auth Z]	KOW	e7pksZ2	A: beta barrels	X: SH3	H: SH3	T: SH3	F: KOW	ECOD (1.6)
CA [auth i]	Lactamase_B_6	e7pksi1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_6	ECOD (1.6)
CA [auth i]	Beta-Casp	e7pksi2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Beta-Casp	ECOD (1.6)
C	RNA_pol_L_1	e7pksC2	A: a+b two layers	X: DCoH-like	H: RBP11-like subunits of RNA polymerase (From Topology)	T: RBP11-like subunits of RNA polymerase	F: RNA_pol_L_1	ECOD (1.6)
C	RNA_pol_A_bac_1	e7pksC1	A: a+b complex topology	X: Ribosomal protein TL5/L25 C-terminal domain-like	H: Insert subdomain of RNA polymerase alpha subunit (From Topology)	T: Insert subdomain of RNA polymerase alpha subunit	F: RNA_pol_A_bac_1	ECOD (1.6)
EA [auth p]	CLASP_N_1	e7pksp1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: CLASP_N_1	ECOD (1.6)
FA [auth q]	Metallophos_2_1	e7pksq1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Metallo-dependent phosphatases (From Topology)	T: Metallo-dependent phosphatases	F: Metallophos_2_1	ECOD (1.6)
D	RNA_pol_Rpb4	e7pksD1	A: alpha arrays	X: HhH/H2TH	H: SAM/DNA-glycosylase	T: SAM domain-like	F: RNA_pol_Rpb4	ECOD (1.6)
E	RNA_pol_Rpb5_C	e7pksE2	A: a+b two layers	X: RPB5-like RNA polymerase subunit (From Topology)	H: RPB5-like RNA polymerase subunit (From Topology)	T: RPB5-like RNA polymerase subunit	F: RNA_pol_Rpb5_C	ECOD (1.6)
E	RNA_pol_Rpb5_N	e7pksE1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Eukaryotic RPB5 N-terminal domain (From Topology)	T: Eukaryotic RPB5 N-terminal domain	F: RNA_pol_Rpb5_N	ECOD (1.6)
F	RNA_pol_Rpb6_1	e7pksF1	A: alpha arrays	X: RPB6/omega subunit-like (From Homology)	H: RPB6/omega subunit-like	T: RPB6	F: RNA_pol_Rpb6_1	ECOD (1.6)
G	S1_1	e7pksG1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: S1_1	ECOD (1.6)
G	SHS2_Rpb7-N	e7pksG2	A: a+b two layers	X: Dodecin subunit-like	H: Flavin-binding protein dodecin-like (From Topology)	T: Flavin-binding protein dodecin-like	F: SHS2_Rpb7-N	ECOD (1.6)
H	RNA_pol_Rpb8	e7pksH1	A: beta barrels	X: OB-fold	H: Nucleic acid-binding proteins (From Topology)	T: Nucleic acid-binding proteins	F: RNA_pol_Rpb8	ECOD (1.6)
I	RNA_POL_M_15KD	e7pksI2	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: RNA_POL_M_15KD	ECOD (1.6)
I	TFIIS_C	e7pksI1	A: few secondary structure elements	X: Rubredoxin-like	H: Rubredoxin-related	T: Rubredoxin-related	F: TFIIS_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00623	RNA polymerase Rpb1, domain 2 (RNA_pol_Rpb1_2)	RNA polymerase Rpb1, domain 2	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 2, contains the active site ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 2, contains the active site. The invariant motif -NADFDGD- binds the active site magnesium ion [1,2].	Domain
A	PF04990	RNA polymerase Rpb1, domain 7 (RNA_pol_Rpb1_7)	RNA polymerase Rpb1, domain 7	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 7, represents a mobile modu ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 7, represents a mobile module of the RNA polymerase. Domain 7 forms a substantial interaction with the lobe domain of Rpb2 (Pfam:PF04561) [1,2].	Domain
A	PF22929	Integrator complex subunit 1, INTS2-binding domain (INTS1_INTS2-bd)	Integrator complex subunit 1, INTS2-binding domain	-	Repeat
A	PF05000	RNA polymerase Rpb1, domain 4 (RNA_pol_Rpb1_4)	RNA polymerase Rpb1, domain 4	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 4, represents the funnel do ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 4, represents the funnel domain. The funnel contain the binding site for some elongation factors [1,2].	Domain
A	PF04983	RNA polymerase Rpb1, domain 3 (RNA_pol_Rpb1_3)	RNA polymerase Rpb1, domain 3	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 3, represents the pore doma ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 3, represents the pore domain. The 3' end of RNA is positioned close to this domain. The pore delimited by this domain is thought to act as a channel through which nucleotides enter the active site and/or where the 3' end of the RNA may be extruded during back-tracking [1,2].	Domain
A	PF04992	RNA polymerase Rpb1, domain 6 (RNA_pol_Rpb1_6)	RNA polymerase Rpb1, domain 6	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 6, represents a mobile modu ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 6, represents a mobile module of the RNA polymerase. Domain 6 forms part of the shelf module [1,2]. This family appears to be specific to the largest subunit of RNA polymerase II.	Domain
A	PF04998	RNA polymerase Rpb1, domain 5 (RNA_pol_Rpb1_5)	RNA polymerase Rpb1, domain 5	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 5, represents the discontin ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 5, represents the discontinuous cleft domain that is required to from the central cleft or channel where the DNA is bound [1,2].	Domain
A	PF04997	RNA polymerase Rpb1, domain 1 (RNA_pol_Rpb1_1)	RNA polymerase Rpb1, domain 1	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 1, represents the clamp dom ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain, domain 1, represents the clamp domain, which a mobile domain involved in positioning the DNA, maintenance of the transcription bubble and positioning of the nascent RNA strand [1,2].	Domain
J	PF01194	RNA polymerases N / 8 kDa subunit (RNA_pol_N)	RNA polymerases N / 8 kDa subunit		Domain
K	PF16661	Metallo-beta-lactamase superfamily domain (Lactamase_B_6)	Metallo-beta-lactamase superfamily domain	This family is part of the metallo-beta-lactamase superfamily.	Domain
K	PF13656	RNA polymerase Rpb3/Rpb11 dimerisation domain (RNA_pol_L_2)	RNA polymerase Rpb3/Rpb11 dimerisation domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation do ...	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000). Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp. Many of the members of this family carry only the N-terminal region of Rpb11.	Domain
L	PF03604	DNA directed RNA polymerase, 7 kDa subunit (Zn_ribbon_RPAB4)	DNA directed RNA polymerase, 7 kDa subunit		Domain
M	PF05001	RNA polymerase Rpb1 C-terminal repeat (RNA_pol_Rpb1_R)	RNA polymerase Rpb1 C-terminal repeat	-	Repeat
R [auth V]	PF06209	Cofactor of BRCA1 (COBRA1) (COBRA1)	Cofactor of BRCA1 (COBRA1)	-	Family
B	PF04561	RNA polymerase Rpb2, domain 2 (RNA_pol_Rpb2_2)	RNA polymerase Rpb2, domain 2	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA po ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain forms one of the two distinctive lobes of the Rpb2 structure. This domain is also known as the lobe domain [1]. DNA has been demonstrated to bind to the concave surface of the lobe domain, and plays a role in maintaining the transcription bubble [1]. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 1 (DRI).	Domain
B	PF04560	RNA polymerase Rpb2, domain 7 (RNA_pol_Rpb2_7)	RNA polymerase Rpb2, domain 7	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA p ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Rpb2 is the second largest subunit of the RNA polymerase. This domain comprised of the structural domains anchor and clamp [1]. The clamp region (C-terminal) contains a zinc-binding motif [1]. The clamp region is named due to its interaction with the clamp domain found in Rpb1. The domain also contains a region termed "switch 4". The switches within the polymerase are thought to signal different stages of transcription [1].	Domain
B	PF04565	RNA polymerase Rpb2, domain 3 (RNA_pol_Rpb2_3)	RNA polymerase Rpb2, domain 3	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 3, s also known as the fork domain and is proximal to catalytic site [1].	Domain
B	PF04566	RNA polymerase Rpb2, domain 4 (RNA_pol_Rpb2_4)	RNA polymerase Rpb2, domain 4	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 4, is also known as the external 2 domain [1].	Domain
B	PF14750	Integrator complex subunit 2 (INTS2)	Integrator complex subunit 2	-	Family
B	PF04563	RNA polymerase beta subunit (RNA_pol_Rpb2_1)	RNA polymerase beta subunit	-	Family
B	PF00562	RNA polymerase Rpb2, domain 6 (RNA_pol_Rpb2_6)	RNA polymerase Rpb2, domain 6	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). This domain represents the hybrid binding domain and the wall domain [1]. The hybrid binding domain binds the nascent RNA strand / template DNA strand in the Pol II transcription elongation complex. This domain contains the important structural motifs, switch 3 and the flap loop and binds an active site metal ion[1]. This domain is also involved in binding to Rpb1 and Rpb3 [1]. Many of the bacterial members contain large insertions within this domain, as region known as dispensable region 2 (DRII).	Domain
B	PF04567	RNA polymerase Rpb2, domain 5 (RNA_pol_Rpb2_5)	RNA polymerase Rpb2, domain 5	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain ...	RNA polymerases catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Domain 5, is also known as the external 2 domain [1].	Domain
U [auth Z]	PF00467	KOW motif (KOW)	KOW motif	-	Family
C	PF01193	RNA polymerase Rpb3/Rpb11 dimerisation domain (RNA_pol_L)	RNA polymerase Rpb3/Rpb11 dimerisation domain	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation do ...	The two eukaryotic subunits Rpb3 and Rpb11 dimerise to from a platform onto which the other subunits of the RNA polymerase assemble (D/L in archaea). The prokaryotic equivalent of the Rpb3/Rpb11 platform is the alpha-alpha dimer. The dimerisation domain of the alpha subunit/Rpb3 is interrupted by an insert domain (Pfam:PF01000). Some of the alpha subunits also contain iron-sulphur binding domains (Pfam:PF00037). Rpb11 is found as a continuous domain. Members of this family include: alpha subunit from eubacteria, alpha subunits from chloroplasts, Rpb3 subunits from eukaryotes, Rpb11 subunits from eukaryotes, RpoD subunits from archaeal spp, and RpoL subunits from archaeal spp.	Domain
C	PF01000	RNA polymerase Rpb3/RpoA insert domain (RNA_pol_A_bac)	RNA polymerase Rpb3/RpoA insert domain	Members of this family include: alpha subunit from eubacteria alpha subunits from chloroplasts Rpb3 subunits from eukaryotes RpoD subunits from archaeal	Domain
D	PF03874	RNA polymerase Rpb4 (RNA_pol_Rpb4)	RNA polymerase Rpb4	-	Family
E	PF01191	RNA polymerase Rpb5, C-terminal domain (RNA_pol_Rpb5_C)	RNA polymerase Rpb5, C-terminal domain	The assembly domain of Rpb5 [1]. The archaeal equivalent to this domain is subunit H. Subunit H lacks the N-terminal domain.	Domain
E	PF03871	RNA polymerase Rpb5, N-terminal domain (RNA_pol_Rpb5_N)	RNA polymerase Rpb5, N-terminal domain	Rpb5 has a bipartite structure which includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H [1,2]. The N-terminal domain is involved in DNA binding and is part of the jaw module in the RNA p ...	Rpb5 has a bipartite structure which includes a eukaryote-specific N-terminal domain and a C-terminal domain resembling the archaeal RNAP subunit H [1,2]. The N-terminal domain is involved in DNA binding and is part of the jaw module in the RNA pol II structure [3]. This module is important for positioning the downstream DNA.	Domain
F	PF01192	RNA polymerase Rpb6 (RNA_pol_Rpb6)	RNA polymerase Rpb6	-	Family
F	PF13519	von Willebrand factor type A domain (VWA_2)	von Willebrand factor type A domain		Domain
H	PF03870	RNA polymerase Rpb8 (RNA_pol_Rpb8)	RNA polymerase Rpb8	-	Family
I	PF02150	RNA polymerases M/15 Kd subunit (Zn_ribbon_RPB9)	RNA polymerases M/15 Kd subunit		Domain
I	PF16661	Metallo-beta-lactamase superfamily domain (Lactamase_B_6)	Metallo-beta-lactamase superfamily domain	This family is part of the metallo-beta-lactamase superfamily.	Domain
I	PF01096	Transcription factor S-II (TFIIS) (Zn_ribbon_TFIIS)	Transcription factor S-II (TFIIS)		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	DNA-directed RNA polymerase subunit	DNA binding binding nucleic acid binding cation binding ion binding metal ion binding small molecule binding	-	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle nuclear lumen transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
J	DNA-directed RNA polymerases I, II, and III subunit RPABC5	DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process tRNA metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process tRNA transcription tRNA transcription by RNA polymerase III RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process tRNA metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process tRNA transcription tRNA transcription by RNA polymerase III metabolic process cellular process macromolecule metabolic process transcription by RNA polymerase III	membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen RNA polymerase III complex RNA polymerase II, holoenzyme nucleoplasm RNA polymerase II, core complex
K	RNA_pol_L_2 domain-containing protein	DNA binding binding nucleic acid binding protein binding protein dimerization activity	-	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
L	RNA polymerase II subunit K	DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity DNA binding binding nucleic acid binding cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus intracellular membrane-bounded organelle
M	RPBI C-terminal domain peptide	DNA binding sequence-specific DNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding binding double-stranded DNA binding core promoter sequence-specific DNA binding nucleic acid binding transcription regulatory region nucleic acid binding cation binding ion binding metal ion binding small molecule binding	-	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen euchromatin membraneless organelle intracellular membraneless organelle chromatin chromosome
N	Non-template DNA	-	-	-
O [auth P]	TAR RNA	-	-	-
P [auth T]	DNA Template	-	-	-
Q [auth U]	Negative elongation factor A	chromatin binding binding molecular adaptor activity	transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of biological process regulation of transcription elongation by RNA polymerase II negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of DNA-templated transcription, elongation regulation of gene expression DNA-templated transcription elongation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process regulation of protein modification process positive regulation of protein metabolic process regulation of protein metabolic process positive regulation of biological process positive regulation of metabolic process positive regulation of protein modification process macromolecule modification positive regulation of macromolecule metabolic process protein metabolic process protein modification process positive regulation of cellular process positive regulation of DNA-templated transcription positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle protein-containing complex transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle protein-containing complex transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen nuclear body
R [auth V]	Negative elongation factor B	RNA binding binding nucleic acid binding	cell population proliferation cellular process transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process cell population proliferation cellular process transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of biological process regulation of transcription elongation by RNA polymerase II negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of DNA-templated transcription, elongation regulation of gene expression DNA-templated transcription elongation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process developmental process stem cell differentiation cellular developmental process cell differentiation negative regulation of stem cell differentiation regulation of developmental process negative regulation of developmental process regulation of cell differentiation regulation of stem cell differentiation negative regulation of cell differentiation	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen cytoplasm
S [auth W]	Negative elongation factor C/D	RNA binding binding nucleic acid binding	transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process transcription elongation by RNA polymerase II regulation of cellular process negative regulation of biological process RNA metabolic process negative regulation of transcription elongation by RNA polymerase II regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase II negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of DNA-templated transcription elongation negative regulation of DNA-templated transcription regulation of biological process regulation of transcription elongation by RNA polymerase II negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process negative regulation of DNA-templated transcription, elongation regulation of gene expression DNA-templated transcription elongation biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle NELF complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen membrane
B	DNA-directed RNA polymerase subunit beta	DNA binding binding nucleic acid binding ribonucleoside binding nucleoside binding heterocyclic compound binding carbohydrate derivative binding small molecule binding cation binding ion binding metal ion binding	-	transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
T [auth X]	Negative elongation factor E	-	-	-
U [auth Z]	Transcription elongation factor SPT5	chromatin binding binding protein heterodimerization activity protein binding protein dimerization activity RNA binding nucleic acid binding mRNA binding enzyme binding	regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of DNA-templated transcription, elongation positive regulation of biosynthetic process regulation of cellular process positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process positive regulation of macromolecule biosynthetic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process positive regulation of metabolic process DNA-templated transcription regulation of RNA metabolic process positive regulation of DNA-templated transcription, elongation positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process positive regulation of nucleobase-containing compound metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression DNA-templated transcription elongation biosynthetic process positive regulation of RNA biosynthetic process cellular process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of biological process negative regulation of RNA biosynthetic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of metabolic process negative regulation of DNA-templated transcription, elongation negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process transcription elongation by RNA polymerase II transcription by RNA polymerase II regulation of transcription elongation by RNA polymerase II positive regulation of autophagy catabolic process macroautophagy autophagy regulation of catabolic process regulation of autophagy positive regulation of catabolic process regulation of macroautophagy positive regulation of macroautophagy process utilizing autophagic mechanism transcription elongation-coupled chromatin remodeling cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II	membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex DSIF complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen membrane-bounded organelle protein-containing complex intracellular anatomical structure transcription elongation factor complex DSIF complex nucleus membrane-enclosed lumen nuclear protein-containing complex intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen
V [auth a]	Integrator complex subunit 1	-	regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death RNA metabolic process regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process U2 snRNA 3'-end processing snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process developmental process multicellular organismal process inner cell mass cell proliferation cell population proliferation developmental growth chordate embryonic development growth embryo development in utero embryonic development multicellular organism development embryo development ending in birth or egg hatching anatomical structure development blastocyst growth blastocyst development multi-multicellular organism process reproductive process female pregnancy embryo implantation multi-organism reproductive process	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane protein-containing complex cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane protein-containing complex integrator complex nuclear protein-containing complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
W [auth b]	Integrator complex subunit 2	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane cytoplasm nuclear membrane endomembrane system membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane cytoplasm nuclear membrane endomembrane system organelle envelope nuclear envelope organelle membrane membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
X [auth d]	Integrator complex subunit 4	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen protein-containing complex integrator complex nuclear protein-containing complex nucleoplasm
Y [auth e]	Integrator complex subunit 5	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cellular anatomical structure membrane membrane-bounded organelle intracellular anatomical structure nuclear membrane nucleus intracellular membrane-bounded organelle endomembrane system intracellular organelle organelle envelope organelle nuclear envelope organelle membrane cytoplasm cytosol protein-containing complex integrator complex nuclear protein-containing complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
Z [auth f]	Integrator complex subunit 6	molecular transducer activity transmembrane signaling receptor activity signaling receptor activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen cytoskeleton membraneless organelle intracellular membraneless organelle actin cytoskeleton
AA [auth g]	Integrator complex subunit 7	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA 3'-end processing macromolecule metabolic process RNA processing cellular response to stimulus response to ionizing radiation response to stimulus cellular response to ionizing radiation response to radiation response to abiotic stimulus cellular response to radiation cellular response to abiotic stimulus cellular response to environmental stimulus transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process DNA damage checkpoint signaling regulation of cell cycle phase transition signaling negative regulation of biological process negative regulation of cell cycle cell cycle phase transition intracellular signal transduction cell communication cellular response to stress response to stress negative regulation of cellular process negative regulation of cell cycle phase transition signal transduction cell cycle regulation of cell cycle cell cycle process regulation of cell cycle process DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling DNA damage response signal transduction in response to DNA damage	intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle protein-containing complex integrator complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm intracellular organelle cellular anatomical structure intracellular anatomical structure organelle membraneless organelle intracellular membraneless organelle chromosome membrane-bounded organelle protein-containing complex integrator complex nucleus nuclear protein-containing complex intracellular membrane-bounded organelle cytoplasm membrane-enclosed lumen intracellular organelle lumen nuclear body nucleoplasm organelle lumen nuclear lumen
BA [auth h]	Integrator complex subunit 8	-	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process snRNA 3'-end processing RNA 3'-end processing	membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen membrane-bounded organelle intracellular organelle protein-containing complex cellular anatomical structure intracellular anatomical structure integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
CA [auth i]	Integrator complex subunit 9	-	cellular response to stimulus negative regulation of transforming growth factor beta receptor signaling pathway regulation of cellular process cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to stimulus negative regulation of transforming growth factor beta receptor signaling pathway regulation of cellular process cell surface receptor protein serine/threonine kinase signaling pathway cellular response to growth factor stimulus response to stimulus negative regulation of signaling signaling cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of biological process regulation of signal transduction negative regulation of cell communication cell communication regulation of transforming growth factor beta receptor signaling pathway cellular response to endogenous stimulus negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway regulation of signaling regulation of biological process cell surface receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation negative regulation of signal transduction response to transforming growth factor beta regulation of response to stimulus transforming growth factor beta receptor signaling pathway regulation of cell communication cellular process response to growth factor transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process snRNA 3'-end processing nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process RNA 3'-end processing macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of transcription elongation by RNA polymerase II regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
C	DNA-directed RNA polymerase II subunit RPB3	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups protein binding protein dimerization activity	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen transferase complex, transferring phosphorus-containing groups protein-containing complex membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
DA [auth k]	Integrator complex subunit 11	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity	RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process snRNA metabolic process biosynthetic process snRNA processing metabolic process cellular process macromolecule metabolic process RNA processing transcription elongation by RNA polymerase II regulation of cellular process regulation of primary metabolic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of DNA-templated transcription elongation regulation of biological process regulation of transcription elongation by RNA polymerase II biological regulation regulation of macromolecule metabolic process regulation of gene expression DNA-templated transcription elongation regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process	cellular anatomical structure extracellular region extracellular space blood microparticle intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex cellular anatomical structure extracellular region extracellular space blood microparticle intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle protein-containing complex integrator complex organelle nucleus nuclear protein-containing complex intracellular membrane-bounded organelle membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
EA [auth p]	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	protein antigen binding protein binding binding antigen binding phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity protein antigen binding protein binding binding antigen binding phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity protein serine/threonine phosphatase activity protein heterodimerization activity protein dimerization activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process meiotic nuclear division cell cycle chromosome segregation spindle organization cell cycle process meiotic cell cycle organelle fission meiotic spindle organization organelle organization nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization mitotic nuclear division chromosome organization sister chromatid segregation mitotic cell cycle mitotic cell cycle process chromosome separation mitotic sister chromatid segregation mitotic sister chromatid separation sister chromatid cohesion meiotic sister chromatid cohesion, centromeric centromeric sister chromatid cohesion meiotic sister chromatid cohesion cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signal transduction in absence of ligand signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process biological regulation positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of growth growth multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis multicellular organismal reproductive process female gamete generation gamete generation female meiotic nuclear division hippo signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction negative regulation of cellular process negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of hippo signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction meiotic cell cycle process involved in oocyte maturation cellular developmental process regulation of reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction oocyte development cell differentiation anatomical structure development cell maturation regulation of cell cycle developmental process regulation of cell cycle process oogenesis regulation of meiotic cell cycle process involved in oocyte maturation developmental maturation anatomical structure maturation germ cell development oocyte maturation oocyte differentiation regulation of developmental process regulation of cell differentiation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol membraneless organelle chromosome, centromeric region intracellular membraneless organelle chromosome chromosomal region somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection synapse cell junction glutamatergic synapse cytoskeleton microtubule cytoskeleton cell body neuronal cell body cell periphery plasma membrane lateral plasma membrane FAR/SIN/STRIPAK complex nucleus
FA [auth q]	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXS140 phosphatase activity myosin phosphatase activity cytoskeletal protein binding protein binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity histone modifying activity histone phosphatase activity histone H2AXS140 phosphatase activity myosin phosphatase activity cytoskeletal protein binding protein binding binding tau protein binding RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity RNA polymerase II CTD heptapeptide repeat modifying activity RNA polymerase II CTD heptapeptide repeat phosphatase activity RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity cation binding ion binding metal ion binding small molecule binding calmodulin-dependent protein phosphatase activity calcium-dependent protein serine/threonine phosphatase activity RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity protein heterodimerization activity protein dimerization activity signaling receptor binding GABA receptor binding protein tyrosine phosphatase activity RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity MAP kinase serine/threonine phosphatase activity MAP kinase phosphatase activity	developmental process anatomical structure development tissue development mesoderm development protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process developmental process anatomical structure development tissue development mesoderm development protein dephosphorylation dephosphorylation primary metabolic process macromolecule modification phosphate-containing compound metabolic process metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process phosphorus metabolic process regulation of growth regulation of biological process biological regulation growth cellular response to stimulus hippo signaling regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction negative regulation of cellular process signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of hippo signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of epithelial to mesenchymal transition multicellular organismal process regulation of developmental process cellular developmental process regulation of cell differentiation mesenchyme development cell differentiation negative regulation of cell differentiation regulation of multicellular organismal process negative regulation of developmental process animal organ development negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of multicellular organismal process peptidyl-serine dephosphorylation regulation of protein modification process positive regulation of phosphorylation regulation of catalytic activity regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of biological process regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process positive regulation of molecular function positive regulation of protein modification process regulation of phosphate metabolic process positive regulation of macromolecule metabolic process positive regulation of protein kinase activity positive regulation of protein phosphorylation positive regulation of cellular process protein phosphorylation positive regulation of transferase activity positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity regulation of phosphorylation regulation of phosphorus metabolic process regulation of metabolic process regulation of protein binding positive regulation of protein binding regulation of binding positive regulation of microtubule binding regulation of microtubule binding positive regulation of binding cell cycle mitotic cell cycle multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction pattern recognition receptor signaling pathway regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly response to biotic stimulus cellular component biogenesis immune response-activating signaling pathway cellular component assembly inflammasome-mediated signaling pathway positive regulation of immune response canonical inflammasome complex assembly regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus positive regulation of intracellular signal transduction positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway defense response to other organism regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly positive regulation of defense response activation of innate immune response regulation of immune response inflammatory response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular component organization positive regulation of cellular component organization regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress response to stress innate immune response protein-containing complex assembly response to external biotic stimulus cellular component organization or biogenesis positive regulation of innate immune response defense response protein-containing complex organization positive regulation of cellular component biogenesis defense response to symbiont regulation of cellular component biogenesis positive regulation of signaling response to metal ion response to chemical response to lead ion ribonucleotide catabolic process pyridine nucleotide catabolic process negative regulation of small molecule metabolic process negative regulation of glycolytic process oxoacid metabolic process carbohydrate catabolic process organophosphate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleoside phosphate catabolic process organic acid metabolic process negative regulation of ATP metabolic process regulation of ATP metabolic process nucleobase-containing compound metabolic process regulation of purine nucleotide catabolic process negative regulation of nucleotide metabolic process regulation of small molecule metabolic process glycolytic process regulation of nucleotide metabolic process pyridine-containing compound metabolic process small molecule metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process purine ribonucleotide catabolic process pyridine nucleotide metabolic process negative regulation of carbohydrate metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process pyruvate metabolic process regulation of carbohydrate catabolic process negative regulation of metabolic process negative regulation of purine nucleotide catabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process catabolic process ATP metabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process regulation of carbohydrate metabolic process nucleotide catabolic process ribonucleoside triphosphate metabolic process negative regulation of nucleotide catabolic process negative regulation of catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate metabolic process carbohydrate derivative catabolic process regulation of glycolytic process through fructose-6-phosphate ADP catabolic process carboxylic acid metabolic process regulation of catabolic process generation of precursor metabolites and energy regulation of glycolytic process purine-containing compound metabolic process ADP metabolic process organophosphate metabolic process negative regulation of phosphorus metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process negative regulation of glycolytic process through fructose-6-phosphate glycolytic process through fructose-6-phosphate regulation of cell cycle phase transition regulation of cell cycle process cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition regulation of mitotic cell cycle phase transition regulation of mitotic cell cycle regulation of G1/S transition of mitotic cell cycle mitotic cell cycle process regulation of cell cycle G1/S transition of mitotic cell cycle cell cycle process mitotic cell cycle phase transition sexual reproduction reproductive process meiotic cell cycle peptidyl-threonine dephosphorylation	intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane extracellular exosome membrane-bounded organelle extracellular vesicle intracellular organelle cellular anatomical structure intracellular anatomical structure cytoskeleton spindle organelle membraneless organelle intracellular membraneless organelle spindle pole microtubule cytoskeleton membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein serine/threonine phosphatase complex cytoplasm cytosol FAR/SIN/STRIPAK complex mitochondrion intracellular membrane-bounded organelle protein phosphatase type 2A complex cell periphery plasma membrane chromosome, centromeric region chromosome chromosomal region membrane microdomain membrane raft synapse cell junction nucleus
GA [auth u]	Unknown	-	-	-
D	RNA polymerase II subunit D	protein binding binding translation initiation factor binding nucleoside phosphate binding nucleotide binding heterocyclic compound binding small molecule binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process transcription initiation at RNA polymerase II promoter	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen RNA polymerase II, holoenzyme protein-containing complex nuclear protein-containing complex transferase complex RNA polymerase II, core complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex
E	DNA-directed RNA polymerase II subunit E	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process nucleolar large rRNA transcription by RNA polymerase I transcription elongation by RNA polymerase I DNA-templated transcription elongation transcription by RNA polymerase I rRNA transcription rRNA metabolic process tRNA metabolic process tRNA transcription tRNA transcription by RNA polymerase III transcription by RNA polymerase III	membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen RNA polymerase II, holoenzyme nucleoplasm RNA polymerase II, core complex RNA polymerase III complex
F	DNA-directed RNA polymerase II subunit F	DNA binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle membrane-bounded organelle protein-containing complex intracellular anatomical structure RNA polymerase I complex nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure membraneless organelle catalytic complex intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen fibrillar center RNA polymerase III complex RNA polymerase II, holoenzyme nucleoplasm RNA polymerase II, core complex
G	DNA-directed RNA polymerase II subunit RPB7	-	-	-
H	DNA-directed RNA polymerases I, II, and III subunit RPABC3	DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process cellular process macromolecule metabolic process	membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex membrane-bounded organelle RNA polymerase II, holoenzyme protein-containing complex intracellular anatomical structure nucleus membrane-enclosed lumen nuclear protein-containing complex transferase complex intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm RNA polymerase II, core complex catalytic complex intracellular membrane-bounded organelle transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex organelle lumen organelle RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex nuclear lumen
I	DNA-directed RNA polymerase II subunit RPB9	binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding transition metal ion binding zinc ion binding binding nucleic acid binding DNA-directed RNA polymerase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding transition metal ion binding zinc ion binding ion binding metal ion binding small molecule binding	RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process DNA-templated transcription initiation RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process transcription initiation at RNA polymerase II promoter transcription elongation by RNA polymerase II maintenance of transcriptional fidelity during transcription elongation DNA-templated transcription elongation maintenance of transcriptional fidelity during transcription elongation by RNA polymerase II cellular response to stimulus response to stimulus transcription-coupled nucleotide-excision repair DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membraneless organelle intracellular membrane-bounded organelle nucleolus intracellular organelle lumen intracellular organelle cellular anatomical structure organelle lumen organelle membraneless organelle nuclear lumen RNA polymerase II, holoenzyme protein-containing complex nuclear protein-containing complex transferase complex nucleoplasm RNA polymerase II, core complex catalytic complex transferase complex, transferring phosphorus-containing groups nuclear DNA-directed RNA polymerase complex RNA polymerase complex DNA-directed RNA polymerase complex intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007081	RNA polymerase Rpb1, domain 5	Domain
A	IPR045867	DNA-directed RNA polymerase, subunit beta-prime	Family
A	IPR007075	RNA polymerase Rpb1, domain 6	Domain
A	IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic	Repeat
A	IPR007083	RNA polymerase Rpb1, domain 4	Domain
A	IPR044893	RNA polymerase Rpb1, clamp domain superfamily	Homologous Superfamily
A	IPR006592	RNA polymerase, N-terminal	Domain
A	IPR007066	RNA polymerase Rpb1, domain 3	Domain
A	IPR007073	RNA polymerase Rpb1, domain 7	Domain
A	IPR042102	RNA polymerase Rpb1, domain 3 superfamily	Homologous Superfamily
A	IPR038593	RNA polymerase Rpb1, domain 7 superfamily	Homologous Superfamily
A	IPR000722	RNA polymerase, alpha subunit	Domain
A	IPR038120	RNA polymerase Rpb1, funnel domain superfamily	Homologous Superfamily
A	IPR007080	RNA polymerase Rpb1, domain 1	Domain
J	IPR023580	RNA polymerase subunit RPB10	Homologous Superfamily
J	IPR020789	RNA polymerases, subunit N, zinc binding site	Binding Site
J	IPR000268	DNA-directed RNA polymerase subunit RPABC5/Rpb10	Family
K	IPR022905	DNA-directed RNA polymerase subunit Rpo11-like	Family
K	IPR009025	DNA-directed RNA polymerase, RBP11-like dimerisation domain	Domain
K	IPR036603	RNA polymerase, RBP11-like subunit	Homologous Superfamily
K	IPR008193	DNA-directed RNA polymerase Rpb11, 13-16kDa subunit, conserved site	Conserved Site
K	IPR037685	RNA polymerase RBP11	Family
L	IPR006591	RNA polymerase archaeal subunit P/eukaryotic subunit RPABC4	Family
L	IPR029040	RNA polymerase subunit RPABC4/transcription elongation factor Spt4	Homologous Superfamily
L	IPR039747	DNA-directed RNA polymerases I, II, and III subunit RPABC4	Family
M	IPR007081	RNA polymerase Rpb1, domain 5	Domain
M	IPR045867	DNA-directed RNA polymerase, subunit beta-prime	Family
M	IPR007075	RNA polymerase Rpb1, domain 6	Domain
M	IPR000684	RNA polymerase II, heptapeptide repeat, eukaryotic	Repeat
M	IPR007083	RNA polymerase Rpb1, domain 4	Domain
M	IPR044893	RNA polymerase Rpb1, clamp domain superfamily	Homologous Superfamily
M	IPR006592	RNA polymerase, N-terminal	Domain
M	IPR007066	RNA polymerase Rpb1, domain 3	Domain
M	IPR007073	RNA polymerase Rpb1, domain 7	Domain
M	IPR042102	RNA polymerase Rpb1, domain 3 superfamily	Homologous Superfamily
M	IPR038593	RNA polymerase Rpb1, domain 7 superfamily	Homologous Superfamily
M	IPR000722	RNA polymerase, alpha subunit	Domain
M	IPR038120	RNA polymerase Rpb1, funnel domain superfamily	Homologous Superfamily
M	IPR007080	RNA polymerase Rpb1, domain 1	Domain
Q [auth U]	IPR037517	Hepatitis delta antigen (HDAg) domain	Domain
Q [auth U]	IPR052828	Negative elongation factor A domain-containing protein	Family
R [auth V]	IPR010405	Cofactor of BRCA1	Family
S [auth W]	IPR006942	TH1 protein	Family
B	IPR007642	RNA polymerase Rpb2, domain 2	Domain
B	IPR015712	DNA-directed RNA polymerase, subunit 2	Family
B	IPR037033	DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily	Homologous Superfamily
B	IPR037034	RNA polymerase Rpb2, domain 2 superfamily	Homologous Superfamily
B	IPR007120	DNA-directed RNA polymerase, subunit 2, hybrid-binding domain	Domain
B	IPR007121	RNA polymerase, beta subunit, conserved site	Conserved Site
B	IPR007645	RNA polymerase Rpb2, domain 3	Domain
B	IPR007646	RNA polymerase Rpb2, domain 4	Domain
B	IPR007647	RNA polymerase Rpb2, domain 5	Domain
B	IPR014724	RNA polymerase Rpb2, OB-fold	Homologous Superfamily
B	IPR007644	RNA polymerase, beta subunit, protrusion	Domain
B	IPR007641	RNA polymerase Rpb2, domain 7	Domain
U [auth Z]	IPR041980	Spt5, KOW domain repeat 6	Domain
U [auth Z]	IPR041976	Spt5, KOW domain repeat 3	Domain
U [auth Z]	IPR039385	NGN domain, eukaryotic	Domain
U [auth Z]	IPR014722	Large ribosomal subunit protein uL2, domain 2	Homologous Superfamily
U [auth Z]	IPR022581	Spt5 transcription elongation factor, N-terminal	Domain
U [auth Z]	IPR024945	Spt5 C-terminal domain	Domain
U [auth Z]	IPR006645	NusG-like, N-terminal	Domain
U [auth Z]	IPR041975	Spt5, KOW domain repeat 2	Domain
U [auth Z]	IPR039659	Transcription elongation factor SPT5	Family
U [auth Z]	IPR036735	NusG, N-terminal domain superfamily	Homologous Superfamily
U [auth Z]	IPR008991	Translation protein SH3-like domain superfamily	Homologous Superfamily
U [auth Z]	IPR041973	Spt5, KOW domain repeat 1	Domain
U [auth Z]	IPR005100	NGN domain	Domain
U [auth Z]	IPR041977	Spt5, KOW domain repeat 4	Domain
U [auth Z]	IPR017071	Transcription elongation factor Spt5, eukaryote	Family
U [auth Z]	IPR005824	KOW	Domain
U [auth Z]	IPR041978	Spt5, KOW domain repeat 5	Domain
V [auth a]	IPR016024	Armadillo-type fold	Homologous Superfamily
V [auth a]	IPR053964	Integrator complex subunit 1, R3 domain	Domain
V [auth a]	IPR053966	Integrator complex subunit 1, INTS2-binding domain	Domain
V [auth a]	IPR022145	Integrator complex subunit 1, RPB2-binding domain	Domain
V [auth a]	IPR053965	Integrator complex subunit 1, R4 domain	Domain
V [auth a]	IPR038902	Integrator complex subunit 1	Family
W [auth b]	IPR026236	Integrator complex subunit 2, metazoa	Family
W [auth b]	IPR029321	Integrator complex subunit 2	Family
X [auth d]	IPR011989	Armadillo-like helical	Homologous Superfamily
X [auth d]	IPR016024	Armadillo-type fold	Homologous Superfamily
Y [auth e]	IPR040316	Integrator complex subunit 5	Family
Y [auth e]	IPR029445	Integrator complex subunit 5, N-terminal	Domain
Y [auth e]	IPR029444	Integrator complex subunit 5, C-terminal	Domain
Z [auth f]	IPR002035	von Willebrand factor, type A	Domain
Z [auth f]	IPR029307	INTS6/SAGE1/DDX26B/CT45, C-terminal	Domain
Z [auth f]	IPR036465	von Willebrand factor A-like domain superfamily	Homologous Superfamily
Z [auth f]	IPR051113	Integrator complex subunit 6	Family
AA [auth g]	IPR016024	Armadillo-type fold	Homologous Superfamily
AA [auth g]	IPR033060	Integrator complex subunit 7	Family
AA [auth g]	IPR054519	Integrator complex subunit 7, C-terminal domain	Domain
BA [auth h]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
BA [auth h]	IPR038751	Integrator complex subunit 8	Family
CA [auth i]	IPR027074	Integrator complex subunit 9	Family
CA [auth i]	IPR001279	Metallo-beta-lactamase	Domain
CA [auth i]	IPR022712	Beta-Casp domain	Domain
CA [auth i]	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
CA [auth i]	IPR048660	Integrator complex subunit 9-like, C-terminal domain	Domain
C	IPR011262	DNA-directed RNA polymerase, insert domain	Domain
C	IPR011263	DNA-directed RNA polymerase, RpoA/D/Rpb3-type	Domain
C	IPR050518	Archaeal Rpo3/Eukaryotic RPB3 RNA Polymerase Subunit	Family
C	IPR022842	DNA-directed RNA polymerase subunit Rpo3/Rpb3/RPAC1	Family
C	IPR036643	DNA-directed RNA polymerase, insert domain superfamily	Homologous Superfamily
C	IPR001514	DNA-directed RNA polymerase, 30-40kDa subunit, conserved site	Conserved Site
C	IPR036603	RNA polymerase, RBP11-like subunit	Homologous Superfamily
DA [auth k]	IPR001279	Metallo-beta-lactamase	Domain
DA [auth k]	IPR050698	RNA Processing Metallo-Beta-Lactamase Domain-Containing Protein	Family
DA [auth k]	IPR022712	Beta-Casp domain	Domain
DA [auth k]	IPR041897	Integrator complex subunit 11, MBL-fold	Domain
DA [auth k]	IPR048662	Integrator complex subunit 11, C-terminal domain	Domain
DA [auth k]	IPR011108	Zn-dependent metallo-hydrolase, RNA specificity domain	Domain
DA [auth k]	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
EA [auth p]	IPR054573	Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat	Domain
EA [auth p]	IPR016024	Armadillo-type fold	Homologous Superfamily
EA [auth p]	IPR021133	HEAT, type 2	Repeat
EA [auth p]	IPR011989	Armadillo-like helical	Homologous Superfamily
EA [auth p]	IPR051023	Protein Phosphatase 2A Regulatory Subunit A	Family
EA [auth p]	IPR000357	HEAT repeat	Repeat
FA [auth q]	IPR047129	Serine/Threonine protein phosphatase PP2A-like	Family
FA [auth q]	IPR004843	Calcineurin-like phosphoesterase domain, ApaH type	Domain
FA [auth q]	IPR029052	Metallo-dependent phosphatase-like	Homologous Superfamily
FA [auth q]	IPR006186	Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase	Domain
D	IPR005574	RNA polymerase subunit Rpb4/RPC9	Family
D	IPR010997	HRDC-like superfamily	Homologous Superfamily
D	IPR006590	RNA polymerase Rpb4/RPC9, core	Domain
D	IPR038324	Rpb4/RPC9 superfamily	Homologous Superfamily
D	IPR045222	DNA-directed RNA polymerase II subunit Rpb4-like	Family
E	IPR014381	DNA-directed RNA polymerase subunit Rpo5/Rpb5	Family
E	IPR036710	RNA polymerase Rpb5, N-terminal domain superfamily	Homologous Superfamily
E	IPR035913	RPB5-like RNA polymerase subunit superfamily	Homologous Superfamily
E	IPR000783	RNA polymerase, subunit H/Rpb5 C-terminal	Domain
E	IPR020608	RNA polymerase, subunit H/Rpb5, conserved site	Conserved Site
E	IPR005571	RNA polymerase, Rpb5, N-terminal	Domain
F	IPR020708	DNA-directed RNA polymerase, 14-18kDa subunit, conserved site	Conserved Site
F	IPR036161	RPB6/omega subunit-like superfamily	Homologous Superfamily
F	IPR028363	DNA-directed RNA polymerase, subunit RPB6	Family
F	IPR006110	RNA polymerase, subunit omega/Rpo6/RPB6	Family
F	IPR006111	Archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit	Family
H	IPR012340	Nucleic acid-binding, OB-fold	Homologous Superfamily
H	IPR005570	DNA-directed RNA polymerases I, II, and III subunit RPABC3	Family
I	IPR001529	DNA-directed RNA polymerase II subunit RPB9-like, zinc ribbon	Domain
I	IPR012164	DNA-directed RNA polymerase subunit/transcription factor S	Family
I	IPR001222	Zinc finger, TFIIS-type	Domain
I	IPR034012	Pol II subunit B9, C-terminal zinc ribbon	Domain
I	IPR019761	DNA-directed RNA polymerase M, 15kDa subunit, conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
Q [auth U]	Pharos: Q9H3P2	Wolf-Hirschhorn syndrome astrocytic tumor large cell medulloblastoma medulloblastoma atypical teratoid rhabdoid tumor lung cancer pilocytic astrocytoma glioblastoma malignant glioma primitive neuroectodermal tumor
R [auth V]	Pharos: Q8WX92	endogenous depression ovarian cancer psoriasis
S [auth W]	Pharos: Q8IXH7	colorectal cancer lung cancer diabetes mellitus ovarian cancer lung adenocarcinoma plasma cell myeloma
U [auth Z]	Pharos: O00267	diabetes mellitus ovarian cancer
V [auth a]	Pharos: Q8N201	intellectual disability malignant mesothelioma psoriasis
W [auth b]	Pharos: Q9H0H0	medulloblastoma ovarian carcinoma osteosarcoma ovarian cancer
X [auth d]	Pharos: Q96HW7	prostate cancer large cell medulloblastoma medulloblastoma Prostatic Neoplasms osteosarcoma Sjogren syndrome
Y [auth e]	Pharos: Q6P9B9	psoriasis
Z [auth f]	Pharos: Q9UL03	lung cancer ovarian cancer tuberculosis malignant mesothelioma Pick disease osteosarcoma sarcoidosis
AA [auth g]	Pharos: Q9NVH2	acute myeloid leukemia ductal breast carcinoma in situ hepatocellular carcinoma lung cancer osteosarcoma atypical teratoid rhabdoid tumor gastric cancer invasive ductal breast carcinoma medulloblastoma pituitary cancer breast cancer gastric carcinoma large cell medulloblastoma nasopharyngeal carcinoma psoriasis
BA [auth h]	Pharos: Q75QN2	intellectual disability lymphoplasmacytic lymphoma medulloblastoma type 2 diabetes mellitus invasive ductal breast carcinoma malignant mesothelioma non-alcoholic fatty liver disease lung cancer maturity-onset diabetes of the young ovarian cancer
CA [auth i]	Pharos: Q9NV88	astrocytic tumor medulloblastoma osteosarcoma
DA [auth k]	Pharos: Q5TA45	astrocytic tumor ulcerative colitis inflammatory bowel disease oligodendroglioma
EA [auth p]	Pharos: P30153	microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome intellectual disability Disease Exacerbation gastric neoplasm osteoarthritis hereditary diffuse gastric adenocarcinoma osteoarthritis susceptibility 1 rheumatoid arthritis gastric cancer
FA [auth q]	Pharos: P67775	asthma heart disease systemic lupus erythematosus adenoma astrocytic tumor coronary artery disease hereditary spastic paraplegia lymphoplasmacytic lymphoma osteosarcoma psoriasis tuberculosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma asthma heart disease systemic lupus erythematosus adenoma astrocytic tumor coronary artery disease hereditary spastic paraplegia lymphoplasmacytic lymphoma osteosarcoma psoriasis tuberculosis allergic rhinitis atypical teratoid rhabdoid tumor glioblastoma large cell medulloblastoma malignant glioma ovarian cancer subependymal giant cell astrocytoma breast cancer lung adenocarcinoma myocardial ischemia plasma cell myeloma