7LER

Netrin-1 filament assembly

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Laminin_N	e7lerA3	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
A	Laminin_EGF_1	e7lerA2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
A	Laminin_EGF	e7lerA4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF	ECOD (1.6)
A	Laminin_EGF_2	e7lerA1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)
C	Laminin_N	e7lerC2	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
C	Laminin_EGF_1	e7lerC4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
C	Laminin_EGF	e7lerC3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF	ECOD (1.6)
C	Laminin_EGF_2	e7lerC1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)
D [auth E]	Laminin_N	e7lerE4	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
D [auth E]	Laminin_EGF_1	e7lerE2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
D [auth E]	Laminin_EGF	e7lerE3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF	ECOD (1.6)
D [auth E]	Laminin_EGF_2	e7lerE1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)
E [auth D]	Laminin_N	e7lerD2	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
E [auth D]	Laminin_EGF_1	e7lerD3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
E [auth D]	Laminin_EGF	e7lerD1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF	ECOD (1.6)
E [auth D]	Laminin_EGF_2	e7lerD4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)
F	Laminin_N	e7lerF1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
F	Laminin_EGF_1	e7lerF3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
F	Laminin_EGF	e7lerF2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF	ECOD (1.6)
F	Laminin_EGF_2	e7lerF4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)
H	Laminin_N	e7lerH4	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
H	Laminin_EGF_1	e7lerH2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
H	Laminin_EGF	e7lerH3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF	ECOD (1.6)
H	Laminin_EGF_2	e7lerH1	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)
B	Laminin_N	e7lerB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
B	Laminin_EGF_1	e7lerB2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
B	Laminin_EGF	e7lerB3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF	ECOD (1.6)
B	Laminin_EGF_2	e7lerB4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)
G	Laminin_N	e7lerG1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Galactose-binding domain-like	F: Laminin_N	ECOD (1.6)
G	Laminin_EGF_1	e7lerG2	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_1	ECOD (1.6)
G	Laminin_EGF	e7lerG3	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF	ECOD (1.6)
G	Laminin_EGF_2	e7lerG4	A: few secondary structure elements	X: EGF-like	H: EGF-related	T: EGF/Laminin	F: Laminin_EGF_2	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	PF00053	Laminin EGF domain (Laminin_EGF)	Laminin EGF domain	This family is like Pfam:PF00008 but has 8 conserved cysteines instead of six.	Domain
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	PF00055	Laminin N-terminal (Domain VI) (Laminin_N)	Laminin N-terminal (Domain VI)	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	Netrin-1	-	developmental process anatomical structure development tissue development anatomical structure morphogenesis animal organ development animal organ morphogenesis ear morphogenesis embryonic organ morphogenesis multicellular organismal process ear development sensory organ development embryonic morphogenesis embryo development multicellular organism development developmental process anatomical structure development tissue development anatomical structure morphogenesis animal organ development animal organ morphogenesis ear morphogenesis embryonic organ morphogenesis multicellular organismal process ear development sensory organ development embryonic morphogenesis embryo development multicellular organism development sensory organ morphogenesis inner ear development inner ear morphogenesis embryonic organ development axon extension regulation of growth regulation of cellular process axonogenesis regulation of cellular component size developmental growth cell projection organization negative regulation of biological process regulation of cell differentiation regulation of neurogenesis neuron projection development regulation of cell development cell projection morphogenesis neuron differentiation negative regulation of growth neuron projection morphogenesis cell differentiation regulation of biological quality system development regulation of biological process negative regulation of cellular component organization regulation of cell projection organization negative regulation of cell growth nervous system development developmental growth involved in morphogenesis generation of neurons negative regulation of axonogenesis negative regulation of developmental growth negative regulation of multicellular organismal process regulation of neuron projection development regulation of cellular component organization cellular developmental process regulation of developmental process plasma membrane bounded cell projection morphogenesis cell development cell growth cell morphogenesis regulation of axon extension cellular component organization regulation of nervous system development neurogenesis negative regulation of neurogenesis regulation of extent of cell growth regulation of axonogenesis negative regulation of cellular process negative regulation of nervous system development regulation of multicellular organismal process negative regulation of cell differentiation cellular component organization or biogenesis negative regulation of cell projection organization regulation of anatomical structure morphogenesis regulation of cell size neuron projection extension regulation of multicellular organismal development regulation of developmental growth plasma membrane bounded cell projection organization developmental cell growth negative regulation of developmental process biological regulation growth negative regulation of axon extension axon development regulation of cell growth cell morphogenesis involved in neuron differentiation negative regulation of neuron projection development negative regulation of cell development neuron development cellular process regulation of plasma membrane bounded cell projection organization regulation of anatomical structure size axon guidance anterior/posterior axon guidance neuron projection guidance establishment of organelle localization cellular localization transport nucleus localization intracellular transport establishment of localization localization organelle localization establishment of localization in cell nuclear migration motor neuron axon guidance cellular response to stimulus negative chemotaxis response to stimulus taxis chemorepulsion of axon locomotion chemotaxis response to external stimulus cellular response to chemical stimulus response to chemical positive regulation of nervous system development positive regulation of developmental process positive regulation of cell projection organization positive regulation of developmental growth positive regulation of cell development positive regulation of multicellular organismal process positive regulation of cellular component organization positive regulation of biological process positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of axon extension positive regulation of cellular process positive regulation of axonogenesis positive regulation of cell growth positive regulation of growth epithelium development tube development mammary gland morphogenesis mammary gland development gland development morphogenesis of an epithelium mammary gland duct morphogenesis tissue morphogenesis tube morphogenesis gland morphogenesis mammary gland epithelium development epithelial tube morphogenesis neuron migration motor neuron migration cell migration cell motility substrate-dependent cell migration, cell extension plasma membrane bounded cell projection assembly cellular component biogenesis cellular component assembly substrate-dependent cell migration cell projection assembly small GTPase-mediated signal transduction signaling Ras protein signal transduction intracellular signal transduction cell communication intracellular signaling cassette signal transduction regulation of cell motility glial cell migration regulation of glial cell migration gliogenesis regulation of locomotion regulation of cell migration dendrite development Cdc42 protein signal transduction Rho protein signal transduction cell junction assembly regulation of synapse structure or activity regulation of synapse assembly synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly cell adhesion cell-cell adhesion positive regulation of locomotion positive regulation of cell motility positive regulation of cell population proliferation regulation of gliogenesis positive regulation of glial cell proliferation positive regulation of gliogenesis regulation of glial cell proliferation cell population proliferation regulation of cell population proliferation glial cell proliferation	basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm basement membrane cell periphery extracellular matrix cellular anatomical structure external encapsulating structure collagen-containing extracellular matrix intracellular organelle intracellular anatomical structure cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen synapse cell junction glutamatergic synapse extracellular region

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	IPR008211	Laminin, N-terminal	Domain
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	IPR002049	Laminin-type EGF domain	Domain
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	IPR018933	Netrin module, non-TIMP type	Domain
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	IPR001134	Netrin domain	Domain
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold	Homologous Superfamily
A, B, C, D [auth E], E [auth D], A, B, C, D [auth E], E [auth D], F, G, H	IPR050440	Laminin/Netrin Extracellular Matrix	Family