7LCZ | pdb_00007lcz

Crystal structure of the ARM domain from Drosophila SARM1 in complex with NMN

External Resource: Annotation

Domain Annotation: ECOD Classification
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Arm	e7lczA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Arm	ECOD (1.6)
B	Arm	e7lczB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Arm	ECOD (1.6)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Isoform B of NAD(+) hydrolase sarm1	protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding STAT family protein binding hydrolase activity, acting on glycosyl bonds NAD+ nucleosidase activity, cyclic ADP-ribose generating hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein-macromolecule adaptor activity molecular adaptor activity signaling adaptor activity transcription factor binding RNA polymerase II-specific DNA-binding transcription factor binding protein binding binding DNA-binding transcription factor binding STAT family protein binding hydrolase activity, acting on glycosyl bonds NAD+ nucleosidase activity, cyclic ADP-ribose generating hydrolase activity hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity NAD+ nucleosidase activity	response to stimulus response to stress response to wounding response to axon injury biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus immune system process defense response to other organism response to stimulus response to stress response to wounding response to axon injury biological process involved in interspecies interaction between organisms immune response response to other organism defense response defense response to symbiont response to external stimulus response to biotic stimulus defense response to virus immune system process defense response to other organism innate immune response antiviral innate immune response response to external biotic stimulus response to virus cellular response to stimulus positive regulation of response to biotic stimulus regulation of cellular process pattern recognition receptor signaling pathway toll-like receptor signaling pathway negative regulation of biological process regulation of signal transduction cell communication immune response-activating signaling pathway positive regulation of immune response regulation of MyD88-independent toll-like receptor signaling pathway regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process regulation of innate immune response regulation of response to stimulus regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response MyD88-independent toll-like receptor signaling pathway regulation of toll-like receptor signaling pathway activation of immune response regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus signaling negative regulation of signaling positive regulation of biological process negative regulation of cell communication positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress negative regulation of cellular process regulation of signaling positive regulation of innate immune response negative regulation of MyD88-independent toll-like receptor signaling pathway negative regulation of response to stimulus biological regulation negative regulation of signal transduction negative regulation of toll-like receptor signaling pathway negative regulation of immune system process regulation of cell communication cellular process positive regulation of cell communication cell surface receptor signaling pathway via STAT positive regulation of signal transduction positive regulation of receptor signaling pathway via STAT positive regulation of cellular process cell surface receptor signaling pathway regulation of receptor signaling pathway via STAT positive regulation of signaling pyridine nucleotide catabolic process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process NAD metabolic process nucleobase-containing compound metabolic process NAD catabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleotide catabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process purine nucleotide catabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process nucleobase-containing compound catabolic process purine-containing compound metabolic process organophosphate metabolic process metabolic process pyridine-containing compound catabolic process	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol somatodendritic compartment cell body neuronal cell body axon cell projection membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle cytosol somatodendritic compartment cell body neuronal cell body axon cell projection neuron projection plasma membrane bounded cell projection dendrite dendritic tree

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A, B	IPR013761	Sterile alpha motif/pointed domain superfamily	Homologous Superfamily
A, B	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A, B	IPR039184	Sterile alpha and TIR motif-containing protein 1	Family
A, B	IPR001660	Sterile alpha motif domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.