7JLG

Human PrimPol extending from the erroneous primer base A opposite the 8-oxoguanine lesion

External Resource: Annotation

Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	DNA_primase_S	e7jlgA1	A: a+b complex topology	X: Prim-pol domain (From Topology)	H: Prim-pol domain (From Topology)	T: Prim-pol domain	F: DNA_primase_S	ECOD (1.6)
D [auth B]	DNA_primase_S	e7jlgB1	A: a+b complex topology	X: Prim-pol domain (From Topology)	H: Prim-pol domain (From Topology)	T: Prim-pol domain	F: DNA_primase_S	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, D [auth B]	PF01896	DNA primase small subunit (DNA_primase_S)	DNA primase small subunit	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, D [auth B]	DNA-directed primase/polymerase protein	catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding catalytic activity, acting on DNA DNA-directed DNA polymerase activity DNA polymerase activity catalytic activity, acting on a nucleic acid transferase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups cation binding manganese ion binding transition metal ion binding ion binding binding metal ion binding small molecule binding chromatin binding DNA-directed 5'-3' RNA polymerase activity DNA primase activity 5'-3' RNA polymerase activity catalytic activity, acting on RNA RNA polymerase activity zinc ion binding	DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process cellular process macromolecule metabolic process replication fork processing translesion synthesis cellular response to stimulus postreplication repair DNA-templated DNA replication DNA-templated DNA replication maintenance of fidelity primary metabolic process DNA metabolic process nucleic acid metabolic process nucleobase-containing compound metabolic process DNA replication metabolic process cellular process macromolecule metabolic process replication fork processing translesion synthesis cellular response to stimulus postreplication repair response to stimulus nucleobase-containing compound biosynthetic process DNA synthesis involved in DNA repair macromolecule biosynthetic process nucleic acid biosynthetic process cellular response to stress biosynthetic process DNA damage response response to stress error-prone translesion synthesis DNA biosynthetic process DNA repair response to light stimulus response to radiation response to abiotic stimulus response to UV cellular component organization chromatin organization chromatin remodeling cellular component organization or biogenesis R-loop processing mitochondrial genome maintenance mitochondrial DNA metabolic process organelle organization mitochondrial DNA repair mitochondrion organization mitochondrial DNA replication	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membraneless organelle replication fork intracellular membraneless organelle chromosome membrane-enclosed lumen mitochondrial matrix membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle membraneless organelle replication fork intracellular membraneless organelle chromosome membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen nucleus transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex RNA polymerase complex DNA-directed RNA polymerase complex transferase complex intracellular protein-containing complex
B [auth C], E [auth G]	DNA (5'-D(PAPTP(8OG)PCPCPTPAPCPCPAPCPAPCPCP*C)-3')	-	-	-
C [auth D], F [auth H]	DNA (5'-D(PGPTPGPTPGPGPTPAPGPGP*A)-3')	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, D [auth B]	IPR002755	DNA primase, small subunit	Family
A, D [auth B]	IPR044917	DNA-directed primase/polymerase protein	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, D [auth B]	Pharos: Q96LW4	myopia 22, autosomal dominant myopia malignant ependymoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia medulloblastoma primitive neuroectodermal tumor mucocutaneous lymph node syndrome ovarian cancer progressive supranuclear palsy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.