Annotations: 7EJO

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	ER	e7ejoA1	A: a+b two layers	X: ERH-like (From Topology)	H: ERH-like (From Topology)	T: ERH-like	F: ER	ECOD (1.6)
B	ER	e7ejoB1	A: a+b two layers	X: ERH-like (From Topology)	H: ERH-like (From Topology)	T: ERH-like	F: ER	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.2260.10	Alpha Beta	2-Layer Sandwich	ERH-like fold	Enhancer of rudimentary	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01133	Enhancer of rudimentary (ER)	Enhancer of rudimentary	-	Family
B	PF01133	Enhancer of rudimentary (ER)	Enhancer of rudimentary	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Enhancer of rudimentary homolog 2,Protein tost-1	-	developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching anatomical structure development embryo development positive regulation of chromosome segregation regulation of chromosome segregation regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation positive regulation of biological process positive regulation of cell cycle developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching anatomical structure development embryo development positive regulation of chromosome segregation regulation of chromosome segregation regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation positive regulation of biological process positive regulation of cell cycle positive regulation of cell cycle process cellular process cell cycle regulation of cell cycle chromosome segregation positive regulation of cellular process cell cycle process positive regulation of cell division cell division regulation of cell division piRNA processing negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process 21U-RNA metabolic process	cellular anatomical structure intracellular anatomical structure perinuclear region of cytoplasm cytoplasm protein-containing complex RNA cap binding complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle
B	Enhancer of rudimentary homolog 2	-	cellular process cell division cell cycle chromosome segregation cell cycle process regulation of cellular process piRNA processing negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing cellular process cell division cell cycle chromosome segregation cell cycle process regulation of cellular process piRNA processing negative regulation of biological process RNA metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of cellular process RNA processing negative regulation of macromolecule metabolic process regulation of biosynthetic process regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of gene expression negative regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process developmental process multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching anatomical structure development embryo development 21U-RNA metabolic process positive regulation of chromosome segregation regulation of chromosome segregation regulation of cell cycle process positive regulation of biological process positive regulation of cell cycle positive regulation of cell cycle process regulation of cell cycle positive regulation of cellular process positive regulation of cell division regulation of cell division	cellular anatomical structure intracellular anatomical structure perinuclear region of cytoplasm cytoplasm protein-containing complex RNA cap binding complex intracellular protein-containing complex membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035912	Enhancer of rudimentary superfamily	Homologous Superfamily
A	IPR000781	Enhancer of rudimentary	Family
B	IPR035912	Enhancer of rudimentary superfamily	Homologous Superfamily
B	IPR000781	Enhancer of rudimentary	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.