7EB6 | pdb_00007eb6

Crystal structure of GTP-binding protein-like domain of AGAP1

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d7eb6a1	Alpha and beta proteins (a/b)	P-loop containing nucleoside triphosphate hydrolases	P-loop containing nucleoside triphosphate hydrolases	G proteins	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d7eb6a2	Artifacts	Tags	Tags	Tags	N-terminal Tags	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Ras-like monodomain GTPases	8102928	4004043	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Ras-like P-loop GTPases	8102929	3002022	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ras_1	e7eb6A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Ras_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00071	Ras family (Ras)	Ras family	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motili ...	Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1	pyrophosphatase activity enzyme regulator activity GTPase activity molecular function activator activity nucleoside-triphosphatase regulator activity hydrolase activity GTPase regulator activity enzyme activator activity ribonucleoside triphosphate phosphatase activity GTPase activator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular function regulator activity hydrolase activity, acting on acid anhydrides catalytic activity pyrophosphatase activity enzyme regulator activity GTPase activity molecular function activator activity nucleoside-triphosphatase regulator activity hydrolase activity GTPase regulator activity enzyme activator activity ribonucleoside triphosphate phosphatase activity GTPase activator activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides molecular function regulator activity hydrolase activity, acting on acid anhydrides catalytic activity binding phospholipid binding lipid binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding	protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process regulation of biological process regulation of cellular component organization regulation of cellular process protein localization establishment of protein localization cellular localization nitrogen compound transport transport establishment of localization localization protein transport cellular macromolecule localization macromolecule localization cellular process regulation of biological process regulation of cellular component organization regulation of cellular process biological regulation regulation of modification of synaptic structure cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity regulation of modification of postsynaptic structure synapse organization cellular component organization or biogenesis regulation of biological quality modification of synaptic structure modification of postsynaptic structure	membrane-bounded organelle intracellular anatomical structure endosome synapse intracellular vesicle intracellular membrane-bounded organelle postsynaptic endosome endomembrane system intracellular organelle postsynapse cellular anatomical structure cytoplasmic vesicle organelle cell junction membrane-bounded organelle intracellular anatomical structure endosome synapse intracellular vesicle intracellular membrane-bounded organelle postsynaptic endosome endomembrane system intracellular organelle postsynapse cellular anatomical structure cytoplasmic vesicle organelle cell junction cytoplasm vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR002110	Ankyrin repeat	Repeat
A	IPR001806	Small GTPase	Family
A	IPR001849	Pleckstrin homology domain	Domain
A	IPR036770	Ankyrin repeat-containing domain superfamily	Homologous Superfamily
A	IPR037278	ARFGAP/RecO-like zinc finger	Homologous Superfamily
A	IPR011993	PH-like domain superfamily	Homologous Superfamily
A	IPR051282	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein	Family
A	IPR001164	Arf GTPase activating protein	Domain
A	IPR038508	ArfGAP domain superfamily	Homologous Superfamily
A	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9UPQ3	astrocytic tumor Autistic Disorder Down syndrome invasive ductal breast carcinoma malignant glioma subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor breast cancer exocrine pancreatic carcinoma large cell medulloblastoma malignant pancreatic neoplasm tuberculosis autism cutaneous lupus erythematosus glioblastoma astrocytic tumor Autistic Disorder Down syndrome invasive ductal breast carcinoma malignant glioma subependymal giant cell astrocytoma atypical teratoid rhabdoid tumor breast cancer exocrine pancreatic carcinoma large cell medulloblastoma malignant pancreatic neoplasm tuberculosis autism cutaneous lupus erythematosus glioblastoma malignant ependymoma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.