7OA4

Crystal structure of the N-terminal endonuclease domain of La Crosse virus L-protein bound to compound L-742,001

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth AAA]	SCOP2B Superfamily	Restriction endonuclease-like	8090963	3000104	SCOP2B (2022-06-29)
B [auth BBB]	SCOP2B Superfamily	Restriction endonuclease-like	8090963	3000104	SCOP2B (2022-06-29)
D [auth GGG]	SCOP2B Superfamily	Restriction endonuclease-like	8090963	3000104	SCOP2B (2022-06-29)
C [auth DDD]	SCOP2B Superfamily	Restriction endonuclease-like	8090963	3000104	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth AAA]	L_protein_N	e7oa4AAA1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: L_protein_N	ECOD (1.6)
B [auth BBB]	L_protein_N	e7oa4BBB1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: L_protein_N	ECOD (1.6)
D [auth GGG]	L_protein_N	e7oa4GGG1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: L_protein_N	ECOD (1.6)
C [auth DDD]	L_protein_N	e7oa4DDD1	A: a/b three-layered sandwiches	X: Restriction endonuclease-like	H: Restriction endonuclease-like (From Topology)	T: Restriction endonuclease-like	F: L_protein_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth AAA], B [auth BBB], C [auth DDD], D [auth GGG]	PF15518	L protein N-terminus (L_protein_N)	L protein N-terminus	This endonuclease domain is found at the N-terminus of many bunyavirus L proteins [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth AAA], B [auth BBB], C [auth DDD], D [auth GGG]	N-terminal endonuclease domain of La Crosse virus L-protein	5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding 5'-3' RNA polymerase activity catalytic activity, acting on RNA catalytic activity, acting on a nucleic acid RNA polymerase activity transferase activity RNA-dependent RNA polymerase activity nucleotidyltransferase activity catalytic activity transferase activity, transferring phosphorus-containing groups binding nucleoside phosphate binding organic cyclic compound binding nucleotide binding heterocyclic compound binding small molecule binding hydrolase activity RNA binding nucleic acid binding cation binding ion binding metal ion binding	RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process RNA metabolic process viral life cycle primary metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process viral genome replication biosynthetic process viral RNA genome replication viral process metabolic process cellular process macromolecule metabolic process gene expression DNA-templated transcription	host intracellular membrane-bounded organelle host cellular component host intracellular part host cell endoplasmic reticulum-Golgi intermediate compartment cellular anatomical structure host cell cytoplasm host cell part host intracellular region host cell cytoplasm part host intracellular organelle host cell endoplasmic reticulum host cell Golgi apparatus virion component

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth AAA], B [auth BBB], C [auth DDD], D [auth GGG]	IPR014384	RNA-directed RNA polymerase, orthobunyavirus	Family
A [auth AAA], B [auth BBB], C [auth DDD], D [auth GGG]	IPR007099	RNA-directed RNA polymerase, negative-strand RNA virus	Domain
A [auth AAA], B [auth BBB], C [auth DDD], D [auth GGG]	IPR029124	RNA-directed RNA polymerase L, N-terminal	Domain
A [auth AAA], B [auth BBB], C [auth DDD], D [auth GGG]	IPR048547	RNA-directed RNA polymerase L, thumb ring domain, bunyaviral	Domain
A [auth AAA], B [auth BBB], C [auth DDD], D [auth GGG]	IPR007322	RNA-dependent RNA polymerase, bunyaviral	Domain
A [auth AAA], B [auth BBB], C [auth DDD], D [auth GGG]	IPR048006	RNA endonuclease, cap-snatching, bunyaviral	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.