6ZLF

Aerobic crystal structure of F420H2-Oxidase from Methanothermococcus thermolithotrophicus at 1.8A resolution under 125 bars of krypton

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6zlfa2	Alpha and beta proteins (a/b)	Flavodoxin-like	Flavoproteins	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
A	d6zlfa1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
C [auth G]	d6zlfg2	Alpha and beta proteins (a/b)	Flavodoxin-like	Flavoproteins	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
C [auth G]	d6zlfg1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
E [auth I]	d6zlfi2	Alpha and beta proteins (a/b)	Flavodoxin-like	Flavoproteins	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
E [auth I]	d6zlfi1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
F [auth J]	d6zlfj2	Alpha and beta proteins (a/b)	Flavodoxin-like	Flavoproteins	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
F [auth J]	d6zlfj1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
G [auth K]	d6zlfk2	Alpha and beta proteins (a/b)	Flavodoxin-like	Flavoproteins	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
G [auth K]	d6zlfk1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
H [auth L]	d6zlfl2	Alpha and beta proteins (a/b)	Flavodoxin-like	Flavoproteins	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
H [auth L]	d6zlfl1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
B [auth F]	d6zlff2	Alpha and beta proteins (a/b)	Flavodoxin-like	Flavoproteins	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
B [auth F]	d6zlff1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
D [auth H]	d6zlfh2	Alpha and beta proteins (a/b)	Flavodoxin-like	Flavoproteins	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)
D [auth H]	d6zlfh1	Alpha and beta proteins (a+b)	Metallo-hydrolase/oxidoreductase	Metallo-hydrolase/oxidoreductase	automated matches	automated matches	(Methanothermococcus thermolithotrophicus ) [TaxId: 2186 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lactamase_B_1	e6zlfA2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_1	ECOD (1.6)
A	Flavodoxin_1	e6zlfA1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: Flavodoxin_1	ECOD (1.6)
C [auth G]	Lactamase_B_1	e6zlfG1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_1	ECOD (1.6)
C [auth G]	Flavodoxin_1	e6zlfG2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: Flavodoxin_1	ECOD (1.6)
E [auth I]	Lactamase_B_1	e6zlfI1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_1	ECOD (1.6)
E [auth I]	Flavodoxin_1	e6zlfI2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: Flavodoxin_1	ECOD (1.6)
F [auth J]	Lactamase_B_1	e6zlfJ1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_1	ECOD (1.6)
F [auth J]	Flavodoxin_1	e6zlfJ2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: Flavodoxin_1	ECOD (1.6)
G [auth K]	Lactamase_B_1	e6zlfK2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_1	ECOD (1.6)
G [auth K]	Flavodoxin_1	e6zlfK1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: Flavodoxin_1	ECOD (1.6)
H [auth L]	Lactamase_B_1	e6zlfL2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_1	ECOD (1.6)
H [auth L]	Flavodoxin_1	e6zlfL1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: Flavodoxin_1	ECOD (1.6)
B [auth F]	Lactamase_B_1	e6zlfF2	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_1	ECOD (1.6)
B [auth F]	Flavodoxin_1	e6zlfF1	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: Flavodoxin_1	ECOD (1.6)
D [auth H]	Lactamase_B_1	e6zlfH1	A: a+b four layers	X: Metallo-hydrolase/oxidoreductase (From Topology)	H: Metallo-hydrolase/oxidoreductase (From Topology)	T: Metallo-hydrolase/oxidoreductase	F: Lactamase_B_1	ECOD (1.6)
D [auth H]	Flavodoxin_1	e6zlfH2	A: a/b three-layered sandwiches	X: Flavodoxin-like	H: Flavoproteins/Phosphotyrosine protein phosphatases-like	T: Flavoproteins	F: Flavodoxin_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	PF19583	ODP family beta lactamase (ODP)	ODP family beta lactamase	The ODP (Oxygen-binding Di-iron Protein) domain is a distinct member of the metallo-beta-lactamase superfamily recruited to various bacterial and archaeal signal transduction pathways, including chemotaxis, to function as oxygen and iron sensors (1). ...	The ODP (Oxygen-binding Di-iron Protein) domain is a distinct member of the metallo-beta-lactamase superfamily recruited to various bacterial and archaeal signal transduction pathways, including chemotaxis, to function as oxygen and iron sensors (1). ODP was shown to act as a sensor for chemotactic responses to both iron and oxygen in the human pathogen Treponema denticola (Td). The ODP di-iron site binds oxygen at high affinity to reversibly form an unusually stable peroxo adduct.	Domain
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	PF00258	Flavodoxin (Flavodoxin_1)	Flavodoxin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	Coenzyme F420H2 oxidase (FprA)	oxidoreductase activity catalytic activity binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding electron transfer activity oxidoreductase activity catalytic activity binding nucleotide binding FMN binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding electron transfer activity cation binding metal ion binding	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	IPR045761	ODP domain	Domain
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	IPR016440	Rubredoxin-oxygen oxidoreductase	Family
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	IPR036866	Ribonuclease Z/Hydroxyacylglutathione hydrolase-like	Homologous Superfamily
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	IPR029039	Flavoprotein-like superfamily	Homologous Superfamily
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	IPR001279	Metallo-beta-lactamase	Domain
A, B [auth F], C [auth G], D [auth H], E [auth I], A, B [auth F], C [auth G], D [auth H], E [auth I], F [auth J], G [auth K], H [auth L]	IPR008254	Flavodoxin/nitric oxide synthase	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.