6YPA

The C146A variant of an amidase from Pyrococcus horikoshii with bound glutaramide

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d6ypaa1	Alpha and beta proteins (a+b)	Carbon-nitrogen hydrolase	Carbon-nitrogen hydrolase	Carbamilase	Hypothetical protein PH0642	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
A	d6ypaa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
B	d6ypab1	Alpha and beta proteins (a+b)	Carbon-nitrogen hydrolase	Carbon-nitrogen hydrolase	Carbamilase	Hypothetical protein PH0642	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
B	d6ypab2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
C	d6ypac1	Alpha and beta proteins (a+b)	Carbon-nitrogen hydrolase	Carbon-nitrogen hydrolase	Carbamilase	Hypothetical protein PH0642	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
C	d6ypac2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
D	d6ypad1	Alpha and beta proteins (a+b)	Carbon-nitrogen hydrolase	Carbon-nitrogen hydrolase	Carbamilase	Hypothetical protein PH0642	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)
D	d6ypad2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Pyrococcus horikoshii ) [TaxId: 53953 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Carbon-nitrogen hydrolases	8036076	3001086	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Carbon-nitrogen hydrolases	8036076	3001086	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Carbon-nitrogen hydrolases	8036076	3001086	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Carbon-nitrogen hydrolases	8036076	3001086	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CN_hydrolase	e6ypaA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Carbon-nitrogen hydrolase (From Topology)	T: Carbon-nitrogen hydrolase	F: CN_hydrolase	ECOD (1.6)
B	CN_hydrolase	e6ypaB1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Carbon-nitrogen hydrolase (From Topology)	T: Carbon-nitrogen hydrolase	F: CN_hydrolase	ECOD (1.6)
C	CN_hydrolase	e6ypaC1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Carbon-nitrogen hydrolase (From Topology)	T: Carbon-nitrogen hydrolase	F: CN_hydrolase	ECOD (1.6)
D	CN_hydrolase	e6ypaD1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: Carbon-nitrogen hydrolase (From Topology)	T: Carbon-nitrogen hydrolase	F: CN_hydrolase	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.110.10	Alpha Beta	4-Layer Sandwich	Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase	Carbon-nitrogen hydrolase	CATH (utative)
B	3.60.110.10	Alpha Beta	4-Layer Sandwich	Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase	Carbon-nitrogen hydrolase	CATH (utative)
C	3.60.110.10	Alpha Beta	4-Layer Sandwich	Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase	Carbon-nitrogen hydrolase	CATH (utative)
D	3.60.110.10	Alpha Beta	4-Layer Sandwich	Nitrilase/N-carbamoyl-D-aminoacid amidohydrolase	Carbon-nitrogen hydrolase	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00795	Carbon-nitrogen hydrolase (CN_hydrolase)	Carbon-nitrogen hydrolase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	CN hydrolase domain-containing protein	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides hydrolase activity catalytic activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR036526	Carbon-nitrogen hydrolase superfamily	Homologous Superfamily
A, B, C, D	IPR050345	Aliphatic Amidase/Beta-Ureidopropionase	Family
A, B, C, D	IPR053613	Aliphatic Nitrilase	Family
A, B, C, D	IPR003010	Carbon-nitrogen hydrolase	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.