6WJ3 | pdb_00006wj3

CryoEM structure of the SLC38A9-RagA-RagC-Ragulator complex in the post-GAP state

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Roadblock/LC7 domain-like	8088845	3001810	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Roadblock/LC7 domain-like	8040242	3001810	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Roadblock/LC7 domain-like	8092495	3001810	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Ras-like P-loop GTPases	8093372	3002022	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Roadblock/LC7 domain-like	8093374	3001810	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ras-like P-loop GTPases	8093371	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Robl_LC7	e6wj3B1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Robl_LC7	ECOD (1.6)
C	MAPKK1_Int	e6wj3C1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: MAPKK1_Int	ECOD (1.6)
D	Robl_LC7	e6wj3D1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Robl_LC7	ECOD (1.6)
E	LAMTOR5	e6wj3E1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: LAMTOR5	ECOD (1.6)
F	Gtr1_RagA_C_1	e6wj3F2	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Gtr1_RagA_C_1	ECOD (1.6)
F	Gtr1_RagA_N	e6wj3F1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Gtr1_RagA_N	ECOD (1.6)
G	Gtr1_RagA_C	e6wj3G1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Gtr1_RagA_C	ECOD (1.6)
G	Gtr1_RagA_N	e6wj3G2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Gtr1_RagA_N	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF03259	Roadblock/LC7 domain (Robl_LC7)	Roadblock/LC7 domain	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is pro ...	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions [2]. This family also includes Swiss:Q9Y2Q5 Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus Swiss:Q50883, a protein involved in gliding motility [4]. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	Domain
C	PF08923	Mitogen-activated protein kinase kinase 1 interacting (MAPKK1_Int)	Mitogen-activated protein kinase kinase 1 interacting	Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a tw ...	Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer [1].	Domain
E	PF16672	Ragulator complex protein LAMTOR5 (LAMTOR5)	Ragulator complex protein LAMTOR5		Domain
F	PF04670	Gtr1/RagA G protein conserved region (Gtr1_RagA)	Gtr1/RagA G protein conserved region	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is ...	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].	Domain
G	PF04670	Gtr1/RagA G protein conserved region (Gtr1_RagA)	Gtr1/RagA G protein conserved region	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is ...	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Ragulator complex protein LAMTOR1	protein binding binding enzyme binding GTPase binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process organelle localization lysosome localization vacuolar localization cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process organelle localization lysosome localization vacuolar localization cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis TORC1 signaling regulation of sterol transport regulation of localization transport regulation of transport lipid localization lipid transport regulation of lipid transport regulation of cholesterol import organic hydroxy compound transport establishment of localization regulation of lipid localization cholesterol transport sterol transport regulation of cholesterol transport cholesterol import sterol homeostasis chemical homeostasis homeostatic process cholesterol homeostasis lipid homeostasis lysosome organization organelle organization vacuole organization lytic vacuole organization positive regulation of TORC1 signaling regulation of TORC1 signaling regulation of protein localization protein localization to vacuole regulation of protein localization to lysosome protein localization to lysosome positive regulation of protein localization to lysosome regulation of cellular localization protein localization to organelle positive regulation of protein localization establishment of localization in cell intracellular transport vesicle-mediated transport endosomal transport intracellular signaling cassette positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade regulation of cholesterol efflux cholesterol efflux cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid localization within membrane protein localization to membrane regulation of receptor recycling regulation of macromolecule metabolic process receptor recycling receptor metabolic process metabolic process macromolecule metabolic process regulation of metabolic process vesicle organization endosome organization endomembrane system organization	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle lytic vacuole lysosome vacuolar membrane azurophil granule vacuole lytic vacuole membrane lysosomal membrane primary lysosome azurophil granule membrane cell periphery plasma membrane membrane microdomain membrane raft Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex endosome membrane endosome late endosome membrane late endosome ficolin-1-rich granule membrane ficolin-1-rich granule tertiary granule
B	Ragulator complex protein LAMTOR2	enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding hydrolase activity, acting on acid anhydrides catalytic activity ribonucleotide binding pyrophosphatase activity GTPase activity binding nucleoside-triphosphatase regulator activity GTPase regulator activity purine ribonucleoside triphosphate binding guanyl-nucleotide exchange factor activity nucleoside phosphate binding purine nucleotide binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides small molecule binding molecular adaptor activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling intracellular signaling cassette positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid cellular component organization cell junction organization regulation of cellular component organization cell-substrate junction organization regulation of cell-substrate junction organization cellular component organization or biogenesis protein localization to cell junction regulation of growth growth regulation of cell growth cell growth ameboidal-type cell migration cell migration fibroblast migration cell motility	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule membrane specific granule vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex endosome membrane endosome cell periphery plasma membrane Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex late endosome late endosome membrane
C	Ragulator complex protein LAMTOR3	enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity kinase activity molecular function regulator activity transferase activity catalytic activity kinase regulator activity transferase activity, transferring phosphorus-containing groups	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling intracellular signaling cassette positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid protein localization to cell junction	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane anchoring junction cell junction focal adhesion cell-substrate junction specific granule membrane specific granule vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle endosome membrane endosome cell periphery plasma membrane Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex late endosome membrane late endosome
D	Ragulator complex protein LAMTOR4	-	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid protein localization to lysosome protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to vacuole cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane late endosome vesicle
E	Ragulator complex protein LAMTOR5	-	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling multicellular organismal process positive regulation of interleukin-8 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process regulation of multicellular organismal process regulation of biosynthetic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of interleukin-8 production positive regulation of canonical NF-kappaB signal transduction intracellular signaling cassette canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid protein localization to lysosome protein localization to vacuole negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size viral genome replication viral process viral life cycle biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus regulation of DNA binding regulation of binding regulation of transcription regulatory region DNA binding positive regulation of binding regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of DNA binding positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of transcription regulatory region DNA binding	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cytosol Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane late endosome vesicle
F	Ras-related GTP-binding protein A	pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity phosphoprotein binding protein binding binding protein heterodimerization activity pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity phosphoprotein binding protein binding binding protein heterodimerization activity protein dimerization activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein homodimerization activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling apoptotic process cell death programmed cell death positive regulation of TORC1 signaling regulation of TORC1 signaling TORC1 signaling cellular response to stress response to stress response to starvation cellular response to starvation cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid protein localization to lysosome protein localization to organelle protein localization to vacuole localization within membrane protein localization to membrane negative regulation of catabolic process catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of catabolic process regulation of autophagy negative regulation of autophagy negative regulation of cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor cellular response to amino acid starvation response to amino acid starvation chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis	GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen lytic vacuole vacuole lysosome catalytic complex GTPase complex Gtr1-Gtr2 GTPase complex vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane
G	Ras-related GTP-binding protein C	pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity protein heterodimerization activity protein binding binding protein dimerization activity pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity protein heterodimerization activity protein binding binding protein dimerization activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding enzyme binding GTPase binding enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity cation binding magnesium ion binding metal ion binding GDP binding protein-membrane adaptor activity	response to acid chemical response to stimulus response to chemical response to amino acid protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus cellular response to nutrient levels response to nutrient levels TOR signaling response to acid chemical response to stimulus response to chemical response to amino acid protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus cellular response to nutrient levels response to nutrient levels TOR signaling regulation of biological process regulation of signaling regulation of cellular process regulation of TOR signaling signaling biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication regulation of TORC1 signaling signal transduction TORC1 signaling apoptotic process cell death programmed cell death RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process macromolecule metabolic process positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of TORC1 signaling positive regulation of response to stimulus positive regulation of TOR signaling positive regulation of cellular process positive regulation of intracellular signal transduction positive regulation of signaling cellular response to stress response to stress response to starvation cellular response to starvation RNA splicing RNA processing cellular response to acid chemical cellular response to amino acid stimulus cellular response to chemical stimulus protein localization to lysosome protein localization to organelle protein localization to vacuole localization within membrane protein localization to membrane negative regulation of catabolic process catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of catabolic process regulation of autophagy negative regulation of autophagy negative regulation of cellular process process utilizing autophagic mechanism regulation of metabolic process cellular response to amino acid starvation response to amino acid starvation small GTPase-mediated signal transduction intracellular signaling cassette	GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen lytic vacuole vacuole lysosome catalytic complex GTPase complex Gtr1-Gtr2 GTPase complex vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane
H	Sodium-coupled neutral amino acid transporter 9	L-arginine transmembrane transporter activity L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity organic cation transmembrane transporter activity transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity basic amino acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity sterol binding binding alcohol binding steroid binding L-arginine transmembrane transporter activity L-amino acid transmembrane transporter activity amino acid transmembrane transporter activity organic cation transmembrane transporter activity transporter activity carboxylic acid transmembrane transporter activity organic acid transmembrane transporter activity basic amino acid transmembrane transporter activity transmembrane transporter activity organic anion transmembrane transporter activity sterol binding binding alcohol binding steroid binding lipid binding cholesterol binding small molecule binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding hydrolase activity, acting on acid anhydrides catalytic activity ribonucleotide binding pyrophosphatase activity GTPase activity nucleoside-triphosphatase regulator activity GTPase regulator activity purine ribonucleoside triphosphate binding guanyl-nucleotide exchange factor activity nucleoside phosphate binding purine nucleotide binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides L-glutamine transmembrane transporter activity neutral L-amino acid transmembrane transporter activity L-leucine transmembrane transporter activity branched-chain amino acid transmembrane transporter activity L-asparagine transmembrane transporter activity amide transmembrane transporter activity cation binding organic acid binding amino acid binding carboxylic acid binding arginine binding metal ion binding lipid sensor activity molecular sensor activity sterol sensor activity	organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport amino acid transmembrane transport L-amino acid transport establishment of localization organic cation transport basic amino acid transmembrane transport L-arginine transmembrane transport organic acid transport transmembrane transport amino acid transport organic acid transmembrane transport organic anion transport nitrogen compound transport carboxylic acid transmembrane transport carboxylic acid transport transport amino acid transmembrane transport L-amino acid transport establishment of localization organic cation transport basic amino acid transmembrane transport L-arginine transmembrane transport organic acid transport transmembrane transport amino acid transport localization basic amino acid transport L-alpha-amino acid transmembrane transport cellular process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication TORC1 signaling positive regulation of signaling cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid asparagine transport neutral amino acid transport glutamine transport	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex endosome intracellular vesicle endomembrane system cytoplasmic vesicle late endosome vesicle endosome membrane late endosome membrane cytoplasmic vesicle membrane vesicle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR028209	LAMTOR1/MEH1	Family
B	IPR037587	Ragulator complex protein LAMTOR2-like	Family
B	IPR004942	Roadblock/LAMTOR2 domain	Domain
C	IPR015019	Ragulator complex protein LAMTOR3	Family
D	IPR034601	Ragulator complex protein LAMTOR4	Family
E	IPR024135	Ragulator complex protein LAMTOR5	Family
F	IPR039397	RagA/B	Family
F	IPR006762	Gtr1/RagA G protein	Family
F	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G	IPR006762	Gtr1/RagA G protein	Family
G	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
G	IPR039400	RagC/D	Family
H	IPR013057	Amino acid transporter, transmembrane domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q6IAA8	malignant pancreatic neoplasm pancreatic ductal adenocarcinoma
B	Pharos: Q9Y2Q5	primary immunodeficiency syndrome due to p14 deficiency breast cancer osteosarcoma Sjogren syndrome pancreatic ductal adenocarcinoma tuberculosis
C	Pharos: Q9UHA4	atypical teratoid rhabdoid tumor interstitial cystitis pancreatic ductal adenocarcinoma psoriasis breast cancer large cell medulloblastoma pancreatic intraductal papillary-mucinous neoplasm glioblastoma ovarian cancer plasma cell myeloma
D	Pharos: Q0VGL1	osteosarcoma ovarian cancer psoriasis
E	Pharos: O43504	breast carcinoma breast cancer lymphoplasmacytic lymphoma Mammary Neoplasms, Human plasma cell myeloma ovarian cancer glucose intolerance pancreatic ductal adenocarcinoma
F	Pharos: Q7L523	large cell medulloblastoma prostate carcinoma ovarian cancer skin basal cell carcinoma pancreatic ductal adenocarcinoma
G	Pharos: Q9HB90	follicular lymphoma Lymphoma, Follicular, Grade 3 osteosarcoma
H	Pharos: Q8NBW4	liver cancer adrenal cortex carcinoma medulloblastoma Pick disease atypical teratoid rhabdoid tumor liver neoplasm ovarian cancer large cell medulloblastoma malignant glioma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.