Annotations: 6U62

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
E	d6u62e_	Alpha and beta proteins (a+b)	Profilin-like	Roadblock/LC7 domain	Roadblock/LC7 domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d6u62f_	Alpha and beta proteins (a+b)	Profilin-like	Roadblock/LC7 domain	Roadblock/LC7 domain	automated matches	Human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Ras-like P-loop GTPases	8093372	3002022	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Roadblock/LC7 domain-like	8093374	3001810	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Ras-like P-loop GTPases	8093371	3002022	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Roadblock/LC7 domain-like	8088845	3001810	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Roadblock/LC7 domain-like	8092495	3001810	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Roadblock/LC7 domain-like	8040242	3001810	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	KOG1517	e6u62A1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 7-bladed	F: KOG1517	ECOD (1.6)
A	Raptor_N,KOG1517,Arm	e6u62A3	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: Raptor_N,KOG1517,Arm	ECOD (1.6)
A	Raptor_N	e6u62A2	A: a/b three-layered sandwiches	X: Caspase-like (From Topology)	H: Caspase-like (From Topology)	T: Caspase-like	F: Raptor_N	ECOD (1.6)
B	Gtr1_RagA_C_1	e6u62B2	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Gtr1_RagA_C_1	ECOD (1.6)
B	Gtr1_RagA_N	e6u62B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Gtr1_RagA_N	ECOD (1.6)
C	Gtr1_RagA_C	e6u62C1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Gtr1_RagA_C	ECOD (1.6)
C	Gtr1_RagA_N	e6u62C2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Gtr1_RagA_N	ECOD (1.6)
E	Robl_LC7	e6u62E1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Robl_LC7	ECOD (1.6)
G	Robl_LC7	e6u62G1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Robl_LC7	ECOD (1.6)
H	LAMTOR5	e6u62H1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: LAMTOR5	ECOD (1.6)
F	MAPKK1_Int	e6u62F1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: MAPKK1_Int	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (utative)
B	3.30.450.190	Alpha Beta	2-Layer Sandwich	Beta-Lactamase		CATH (utative)
E	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (utative)
H	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (utative)
F	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF14538	Raptor N-terminal CASPase like domain (Raptor_N)	Raptor N-terminal CASPase like domain	This domain is found at the N-terminus of the Raptor protein. It has been identified to have a CASPase like structure [1]. It conserves the characteristic cys/his dyad of the caspases suggesting it may have a peptidase activity.	Domain
A	PF00400	WD domain, G-beta repeat (WD40)	WD domain, G-beta repeat	-	Repeat
A	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat
B	PF04670	Gtr1/RagA G protein conserved region (Gtr1_RagA)	Gtr1/RagA G protein conserved region	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is ...	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].	Domain
C	PF04670	Gtr1/RagA G protein conserved region (Gtr1_RagA)	Gtr1/RagA G protein conserved region	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is ...	GTR1 was first identified in S. cerevisiae as a suppressor of a mutation in RCC1. Biochemical analysis revealed that Gtr1 is in fact a G protein of the Ras family. The RagA/B proteins are the human homologues of Gtr1. Included in this family is the human Rag C, a novel protein that has been shown to interact with RagA/B [1,2,3,4].	Domain
E	PF03259	Roadblock/LC7 domain (Robl_LC7)	Roadblock/LC7 domain	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is pro ...	This family includes proteins that are about 100 amino acids long and have been shown to be related [3]. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions [2]. This family also includes Swiss:Q9Y2Q5 Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus Swiss:Q50883, a protein involved in gliding motility [4]. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.	Domain
H	PF16672	Ragulator complex protein LAMTOR5 (LAMTOR5)	Ragulator complex protein LAMTOR5		Domain
F	PF08923	Mitogen-activated protein kinase kinase 1 interacting (MAPKK1_Int)	Mitogen-activated protein kinase kinase 1 interacting	Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a tw ...	Mitogen-activated protein kinase kinase 1 interacting protein is a small subcellular adaptor protein required for MAPK signaling and ERK1/2 activation. The overall topology of this domain has a central five-stranded beta-sheet sandwiched between a two alpha-helix and a one alpha-helix layer [1].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Regulatory-associated protein of mTOR	small GTPase binding protein binding binding enzyme binding GTPase binding protein-macromolecule adaptor activity molecular adaptor activity 14-3-3 protein binding protein-containing complex binding enzyme regulator activity catalytic activity, acting on a protein molecular function activator activity kinase activity protein kinase activity small GTPase binding protein binding binding enzyme binding GTPase binding protein-macromolecule adaptor activity molecular adaptor activity 14-3-3 protein binding protein-containing complex binding enzyme regulator activity catalytic activity, acting on a protein molecular function activator activity kinase activity protein kinase activity transferase activity protein kinase regulator activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups kinase activator activity enzyme activator activity molecular function regulator activity protein kinase activator activity catalytic activity kinase regulator activity enzyme-substrate adaptor activity kinase binding protein kinase binding protein serine/threonine kinase activity enzyme inhibitor activity protein kinase inhibitor activity molecular function inhibitor activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process response to chemical response to xenobiotic stimulus response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to oxygen levels response to abiotic stimulus cellular component organization regulation of cellular component size biological regulation cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size cellular response to nutrient levels response to nutrient levels positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth TORC1 signaling positive regulation of phosphorylation regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification regulation of primary metabolic process positive regulation of metabolic process positive regulation of protein modification process peptidyl-serine phosphorylation regulation of phosphate metabolic process phosphate-containing compound metabolic process peptidyl-amino acid modification positive regulation of macromolecule metabolic process protein metabolic process positive regulation of protein phosphorylation phosphorus metabolic process protein modification process protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process positive regulation of peptidyl-serine phosphorylation macromolecule modification regulation of phosphorus metabolic process metabolic process regulation of phosphorylation macromolecule metabolic process regulation of metabolic process regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of cell cycle process positive regulation of mitotic cell cycle cell cycle regulation of cell cycle cell cycle process positive regulation of G1/S transition of mitotic cell cycle regulation of cell cycle process positive regulation of cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition regulation of amide metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy nucleobase-containing compound metabolic process regulation of small molecule metabolic process regulation of nucleotide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt pyridine-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process positive regulation of nucleobase-containing compound metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process positive regulation of pentose-phosphate shunt catabolic process positive regulation of nucleotide metabolic process glucose 6-phosphate metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process regulation of NADP metabolic process amide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process generation of precursor metabolites and energy regulation of catabolic process purine-containing compound metabolic process NADP metabolic process positive regulation of purine nucleotide metabolic process NADPH regeneration organophosphate metabolic process positive regulation of small molecule metabolic process response to starvation cellular response to starvation cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical response to amino acid negative regulation of catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of autophagy negative regulation of autophagy negative regulation of cellular process process utilizing autophagic mechanism response to osmotic stress cellular response to chemical stress cellular response to osmotic stress cellular response to environmental stimulus cellular response to abiotic stimulus cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound cellular response to L-leucine cellular response to oxygen-containing compound response to L-leucine positive regulation of cell growth positive regulation of growth ribonucleotide catabolic process pyridine nucleotide catabolic process oxoacid metabolic process organophosphate catabolic process nucleoside phosphate catabolic process organic acid metabolic process regulation of ATP metabolic process regulation of purine nucleotide catabolic process positive regulation of nucleotide catabolic process glycolytic process purine ribonucleotide catabolic process pyruvate metabolic process purine nucleoside diphosphate metabolic process purine-containing compound catabolic process nucleobase-containing compound catabolic process positive regulation of ATP metabolic process nucleoside diphosphate metabolic process purine nucleoside diphosphate catabolic process nucleoside diphosphate catabolic process regulation of nucleotide catabolic process positive regulation of carbohydrate metabolic process nucleoside triphosphate metabolic process monocarboxylic acid metabolic process purine ribonucleotide metabolic process pyridine-containing compound catabolic process ribose phosphate metabolic process ATP metabolic process positive regulation of purine nucleotide catabolic process ribonucleotide metabolic process purine ribonucleoside triphosphate metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process ribonucleoside triphosphate metabolic process nucleotide catabolic process purine nucleoside triphosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process positive regulation of glycolytic process ADP catabolic process carboxylic acid metabolic process regulation of glycolytic process positive regulation of catabolic process ADP metabolic process purine ribonucleoside diphosphate metabolic process purine ribonucleoside diphosphate catabolic process regulation of peptidyl-threonine phosphorylation peptidyl-threonine modification positive regulation of peptidyl-threonine phosphorylation peptidyl-threonine phosphorylation homeostatic process cellular response to glucose stimulus intracellular glucose homeostasis response to hexose cellular response to carbohydrate stimulus cellular homeostasis response to monosaccharide response to carbohydrate chemical homeostasis response to glucose glucose homeostasis carbohydrate homeostasis cellular response to hexose stimulus intracellular chemical homeostasis cellular response to monosaccharide stimulus regulation of biosynthetic process regulation of lipid metabolic process lipid biosynthetic process positive regulation of lipid biosynthetic process biosynthetic process positive regulation of biosynthetic process positive regulation of lipid metabolic process regulation of lipid biosynthetic process lipid metabolic process multicellular organismal process positive regulation of odontoblast differentiation cellular developmental process regulation of developmental process regulation of cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation positive regulation of developmental process multicellular organism development positive regulation of cell differentiation cell differentiation anatomical structure development neuroepithelial cell differentiation regulation of multicellular organismal process odontoblast differentiation developmental process epithelium development regulation of multicellular organismal development regulation of odontoblast differentiation tissue development positive regulation of epithelial cell differentiation columnar/cuboidal epithelial cell differentiation positive regulation of neuroepithelial cell differentiation behavior biological process involved in intraspecies interaction between organisms social behavior positive regulation of DNA-templated transcription positive regulation of transcription by RNA polymerase III RNA metabolic process positive regulation of macromolecule biosynthetic process RNA biosynthetic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process transcription by RNA polymerase III regulation of RNA biosynthetic process regulation of transcription by RNA polymerase III nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process regulation of gene expression positive regulation of RNA biosynthetic process regulation of macromolecule biosynthetic process regulation of DNA-templated transcription cell population proliferation positive regulation of cell population proliferation endothelial cell proliferation positive regulation of epithelial cell proliferation regulation of endothelial cell proliferation regulation of cell population proliferation positive regulation of endothelial cell proliferation regulation of epithelial cell proliferation epithelial cell proliferation myeloid leukocyte differentiation regulation of leukocyte differentiation cell development positive regulation of osteoclast differentiation regulation of cell development regulation of osteoclast differentiation positive regulation of hemopoiesis osteoclast differentiation regulation of immune system process positive regulation of immune system process hemopoiesis regulation of myeloid cell differentiation positive regulation of cell development regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation immune system process positive regulation of myeloid cell differentiation regulation of hemopoiesis positive regulation of multicellular organismal process positive regulation of leukocyte differentiation leukocyte differentiation	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection vacuolar membrane membrane-bounded organelle membrane lytic vacuole cellular anatomical structure intracellular anatomical structure cytoplasm cytosol somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection vacuolar membrane membrane-bounded organelle membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle organelle lysosomal membrane organelle membrane lysosome cell body neuronal cell body protein-containing complex TORC1 complex TOR complex intracellular protein-containing complex cytoplasmic ribonucleoprotein granule intracellular membraneless organelle ribonucleoprotein granule membraneless organelle supramolecular complex cytoplasmic stress granule nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen
B	Ras-related GTP-binding protein A	pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity phosphoprotein binding protein binding binding protein heterodimerization activity pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity phosphoprotein binding protein binding binding protein heterodimerization activity protein dimerization activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity identical protein binding protein homodimerization activity ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling apoptotic process cell death programmed cell death positive regulation of TORC1 signaling regulation of TORC1 signaling TORC1 signaling cellular response to stress response to stress response to starvation cellular response to starvation cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid protein localization to lysosome protein localization to organelle protein localization to vacuole localization within membrane protein localization to membrane negative regulation of catabolic process catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of catabolic process regulation of autophagy negative regulation of autophagy negative regulation of cellular process metabolic process process utilizing autophagic mechanism regulation of metabolic process cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor cellular response to amino acid starvation response to amino acid starvation chemical homeostasis homeostatic process glucose homeostasis carbohydrate homeostasis	GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen lytic vacuole vacuole lysosome catalytic complex GTPase complex Gtr1-Gtr2 GTPase complex vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane
C	Ras-related GTP-binding protein C	pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity protein heterodimerization activity protein binding binding protein dimerization activity pyrophosphatase activity GTPase activity GTPase motor activity ribonucleoside triphosphate phosphatase activity cytoskeletal motor activity membrane scission GTPase motor activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity protein heterodimerization activity protein binding binding protein dimerization activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding enzyme binding GTPase binding enzyme-substrate adaptor activity protein-macromolecule adaptor activity molecular adaptor activity cation binding magnesium ion binding metal ion binding GDP binding protein-membrane adaptor activity	response to acid chemical response to stimulus response to chemical response to amino acid protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus cellular response to nutrient levels response to nutrient levels TOR signaling response to acid chemical response to stimulus response to chemical response to amino acid protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process cellular response to stimulus cellular response to nutrient levels response to nutrient levels TOR signaling regulation of biological process regulation of signaling regulation of cellular process regulation of TOR signaling signaling biological regulation regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication regulation of TORC1 signaling signal transduction TORC1 signaling apoptotic process cell death programmed cell death RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process biosynthetic process metabolic process macromolecule metabolic process positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of TORC1 signaling positive regulation of response to stimulus positive regulation of TOR signaling positive regulation of cellular process positive regulation of intracellular signal transduction positive regulation of signaling cellular response to stress response to stress response to starvation cellular response to starvation RNA splicing RNA processing cellular response to acid chemical cellular response to amino acid stimulus cellular response to chemical stimulus protein localization to lysosome protein localization to organelle protein localization to vacuole localization within membrane protein localization to membrane negative regulation of catabolic process catabolic process negative regulation of metabolic process autophagy negative regulation of biological process regulation of catabolic process regulation of autophagy negative regulation of autophagy negative regulation of cellular process process utilizing autophagic mechanism regulation of metabolic process cellular response to amino acid starvation response to amino acid starvation small GTPase-mediated signal transduction intracellular signaling cassette	GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen lytic vacuole vacuole lysosome catalytic complex GTPase complex Gtr1-Gtr2 GTPase complex vacuolar membrane membrane lytic vacuole membrane bounding membrane of organelle lysosomal membrane organelle membrane
D	Ragulator complex protein LAMTOR1	protein binding binding enzyme binding GTPase binding protein-membrane adaptor activity protein-macromolecule adaptor activity molecular adaptor activity	protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process organelle localization lysosome localization vacuolar localization cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular process organelle localization lysosome localization vacuolar localization cellular response to stimulus cellular response to nutrient levels response to nutrient levels response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of signaling regulation of growth regulation of cellular component organization growth regulation of cell growth cell growth cellular component organization cellular component organization or biogenesis TORC1 signaling regulation of sterol transport regulation of localization transport regulation of transport lipid localization lipid transport regulation of lipid transport regulation of cholesterol import organic hydroxy compound transport establishment of localization regulation of lipid localization cholesterol transport sterol transport regulation of cholesterol transport cholesterol import sterol homeostasis chemical homeostasis homeostatic process cholesterol homeostasis lipid homeostasis lysosome organization organelle organization vacuole organization lytic vacuole organization positive regulation of TORC1 signaling regulation of TORC1 signaling regulation of protein localization protein localization to vacuole regulation of protein localization to lysosome protein localization to lysosome positive regulation of protein localization to lysosome regulation of cellular localization protein localization to organelle positive regulation of protein localization establishment of localization in cell intracellular transport vesicle-mediated transport endosomal transport intracellular signaling cassette positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade regulation of cholesterol efflux cholesterol efflux cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid localization within membrane protein localization to membrane regulation of receptor recycling regulation of macromolecule metabolic process receptor recycling receptor metabolic process metabolic process macromolecule metabolic process regulation of metabolic process vesicle organization endosome organization endomembrane system organization	membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle membrane-bounded organelle intracellular anatomical structure membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system specific granule membrane intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle lytic vacuole lysosome vacuolar membrane azurophil granule vacuole lytic vacuole membrane lysosomal membrane primary lysosome azurophil granule membrane cell periphery plasma membrane membrane microdomain membrane raft Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex endosome membrane endosome late endosome membrane late endosome ficolin-1-rich granule membrane ficolin-1-rich granule tertiary granule
E	Ragulator complex protein LAMTOR2	enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding enzyme regulator activity guanyl nucleotide binding GTP binding nucleotide binding hydrolase activity guanyl ribonucleotide binding GDP binding purine ribonucleotide binding ion binding ribonucleoside triphosphate phosphatase activity anion binding molecular function regulator activity heterocyclic compound binding carbohydrate derivative binding hydrolase activity, acting on acid anhydrides catalytic activity ribonucleotide binding pyrophosphatase activity GTPase activity binding nucleoside-triphosphatase regulator activity GTPase regulator activity purine ribonucleoside triphosphate binding guanyl-nucleotide exchange factor activity nucleoside phosphate binding purine nucleotide binding hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides small molecule binding molecular adaptor activity	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling intracellular signaling cassette positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid cellular component organization cell junction organization regulation of cellular component organization cell-substrate junction organization regulation of cell-substrate junction organization cellular component organization or biogenesis protein localization to cell junction regulation of growth growth regulation of cell growth cell growth ameboidal-type cell migration cell migration fibroblast migration cell motility	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane specific granule membrane specific granule vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex endosome membrane endosome cell periphery plasma membrane Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex late endosome late endosome membrane
G	Ragulator complex protein LAMTOR4	-	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid protein localization to lysosome protein localization localization cellular localization protein localization to organelle cellular macromolecule localization macromolecule localization protein localization to vacuole cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane late endosome vesicle
H	Ragulator complex protein LAMTOR5	-	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling multicellular organismal process positive regulation of interleukin-8 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process regulation of multicellular organismal process regulation of biosynthetic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression positive regulation of multicellular organismal process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of interleukin-8 production positive regulation of canonical NF-kappaB signal transduction intracellular signaling cassette canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction protein localization regulation of localization cellular localization regulation of protein localization positive regulation of protein localization to nucleus regulation of protein localization to nucleus protein localization to nucleus localization regulation of cellular localization cellular macromolecule localization macromolecule localization protein localization to organelle positive regulation of protein localization positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process primary metabolic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of molecular function regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid protein localization to lysosome protein localization to vacuole negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death cellular component organization regulation of cellular component size cellular component organization or biogenesis regulation of biological quality regulation of cell size regulation of anatomical structure size viral genome replication viral process viral life cycle biological process involved in interspecies interaction between organisms response to other organism response to external stimulus response to external biotic stimulus response to virus response to biotic stimulus regulation of DNA binding regulation of binding regulation of transcription regulatory region DNA binding positive regulation of binding regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of DNA binding positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding positive regulation of transcription regulatory region DNA binding	vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm vacuolar membrane membrane-bounded organelle intracellular anatomical structure membrane lytic vacuole vacuole intracellular membrane-bounded organelle intracellular organelle lytic vacuole membrane bounding membrane of organelle cellular anatomical structure organelle lysosomal membrane cytoplasm organelle membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex cytosol Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane cytoplasmic vesicle vesicle membrane late endosome vesicle
F	Ragulator complex protein LAMTOR3	enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity kinase activity molecular function regulator activity transferase activity catalytic activity kinase regulator activity transferase activity, transferring phosphorus-containing groups	cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction positive regulation of TORC1 signaling intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction positive regulation of TOR signaling signal transduction regulation of TORC1 signaling positive regulation of cellular process TOR signaling regulation of biological process regulation of signaling regulation of TOR signaling biological regulation positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication cellular process TORC1 signaling positive regulation of signaling intracellular signaling cassette positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade protein localization localization cellular localization cellular macromolecule localization macromolecule localization cellular response to acid chemical cellular response to amino acid stimulus response to acid chemical cellular response to chemical stimulus response to chemical response to amino acid protein localization to cell junction	membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle membrane-bounded organelle intracellular anatomical structure tertiary granule membrane membrane intracellular vesicle intracellular membrane-bounded organelle endomembrane system tertiary granule intracellular organelle cytoplasmic vesicle membrane cellular anatomical structure bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle secretory granule secretory vesicle cytoplasm vesicle organelle membrane secretory granule membrane anchoring junction cell junction focal adhesion cell-substrate junction specific granule membrane specific granule vacuolar membrane lytic vacuole vacuole lytic vacuole membrane lysosomal membrane lysosome GTPase activator complex protein-containing complex FNIP-folliculin RagC/D GAP enzyme activator complex extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space extracellular membrane-bounded organelle endosome membrane endosome cell periphery plasma membrane Ragulator complex membrane protein complex guanyl-nucleotide exchange factor complex intracellular protein-containing complex late endosome membrane late endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR016024	Armadillo-type fold	Homologous Superfamily
A	IPR004083	Regulatory associated protein of TOR	Family
A	IPR029347	Raptor, N-terminal CASPase-like domain	Domain
A	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
A	IPR000357	HEAT repeat	Repeat
A	IPR011989	Armadillo-like helical	Homologous Superfamily
A	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
A	IPR001680	WD40 repeat	Repeat
B	IPR039397	RagA/B	Family
B	IPR006762	Gtr1/RagA G protein	Family
B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR006762	Gtr1/RagA G protein	Family
C	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
C	IPR039400	RagC/D	Family
D	IPR028209	LAMTOR1/MEH1	Family
E	IPR037587	Ragulator complex protein LAMTOR2-like	Family
E	IPR004942	Roadblock/LAMTOR2 domain	Domain
G	IPR034601	Ragulator complex protein LAMTOR4	Family
H	IPR024135	Ragulator complex protein LAMTOR5	Family
F	IPR015019	Ragulator complex protein LAMTOR3	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q8N122	nicotine dependence hypertensive disorder Sjogren syndrome Tobacco Dependence
B	Pharos: Q7L523	large cell medulloblastoma prostate carcinoma ovarian cancer skin basal cell carcinoma pancreatic ductal adenocarcinoma
C	Pharos: Q9HB90	follicular lymphoma Lymphoma, Follicular, Grade 3 osteosarcoma
D	Pharos: Q6IAA8	malignant pancreatic neoplasm pancreatic ductal adenocarcinoma
E	Pharos: Q9Y2Q5	primary immunodeficiency syndrome due to p14 deficiency breast cancer osteosarcoma Sjogren syndrome pancreatic ductal adenocarcinoma tuberculosis
G	Pharos: Q0VGL1	osteosarcoma ovarian cancer psoriasis
H	Pharos: O43504	breast carcinoma breast cancer lymphoplasmacytic lymphoma Mammary Neoplasms, Human plasma cell myeloma ovarian cancer glucose intolerance pancreatic ductal adenocarcinoma
F	Pharos: Q9UHA4	atypical teratoid rhabdoid tumor interstitial cystitis pancreatic ductal adenocarcinoma psoriasis breast cancer large cell medulloblastoma pancreatic intraductal papillary-mucinous neoplasm glioblastoma ovarian cancer plasma cell myeloma