Annotations: 6PBZ

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d6pbzb3	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d6pbzb1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d6pbzc3	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d6pbzc1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d6pbzd3	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d6pbzd1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
A	d6pbza3	All alpha proteins	HD-domain/PDEase-like	HD-domain/PDEase-like	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
A	d6pbza1	Alpha and beta proteins (a/b)	Ribonuclease H-like motif	Actin-like ATPase domain	automated matches	automated matches	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	PRK10854	e6pbzB1	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PRK10854	ECOD (1.6)
B	Ppx-GppA_N	e6pbzB3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ppx-GppA_N	ECOD (1.6)
B	Ppx-GppA_C	e6pbzB2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ppx-GppA_C	ECOD (1.6)
C	PRK10854	e6pbzC3	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PRK10854	ECOD (1.6)
C	Ppx-GppA_N	e6pbzC2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ppx-GppA_N	ECOD (1.6)
C	Ppx-GppA_C	e6pbzC1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ppx-GppA_C	ECOD (1.6)
D	PRK10854	e6pbzD2	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PRK10854	ECOD (1.6)
D	Ppx-GppA_N	e6pbzD3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ppx-GppA_N	ECOD (1.6)
D	Ppx-GppA_C	e6pbzD1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ppx-GppA_C	ECOD (1.6)
A	PRK10854	e6pbzA3	A: alpha complex topology	X: PDEase-like	H: HD-domain/PDEase-like (From Topology)	T: HD-domain/PDEase-like	F: PRK10854	ECOD (1.6)
A	Ppx-GppA_N	e6pbzA2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ppx-GppA_N	ECOD (1.6)
A	Ppx-GppA_C	e6pbzA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Ppx-GppA_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF02541	Ppx/GppA phosphatase family (Ppx-GppA)	Ppx/GppA phosphatase family	-	Family
A, B, C, D	PF21447	Ppx/GppA phosphatase, domain III (Ppx-GppA_III)	Ppx/GppA phosphatase, domain III	Ppx/GppA phosphatases belong to ASKHA (acetate and sugar kinases, Hsp70, actin) which has an N-terminal (Pfam:PF02541) nucleotide-binding domain (domains I/II), domain III which corresponds to the catalytic phosphohydrolase domain with the common hel ...	Ppx/GppA phosphatases belong to ASKHA (acetate and sugar kinases, Hsp70, actin) which has an N-terminal (Pfam:PF02541) nucleotide-binding domain (domains I/II), domain III which corresponds to the catalytic phosphohydrolase domain with the common helical fold and domain IV [1-3]. This entry represents domain III.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase	pyrophosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity hydrolase activity, acting on acid anhydrides catalytic activity	ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleotide catabolic process guanosine pentaphosphate catabolic process ribonucleoside bisphosphate metabolic process catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process purine ribonucleoside bisphosphate catabolic process purine nucleoside bisphosphate catabolic process purine ribonucleoside bisphosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleotide catabolic process guanosine pentaphosphate catabolic process ribonucleoside bisphosphate metabolic process catabolic process carbohydrate derivative metabolic process organophosphate catabolic process nucleoside phosphate catabolic process purine ribonucleoside bisphosphate catabolic process purine nucleoside bisphosphate catabolic process purine ribonucleoside bisphosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process nucleoside bisphosphate catabolic process small molecule metabolic process purine ribonucleotide catabolic process phosphorus metabolic process nucleotide catabolic process nucleoside phosphate metabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process primary metabolic process purine-containing compound catabolic process nucleotide metabolic process purine-containing compound metabolic process nucleobase-containing compound catabolic process guanosine pentaphosphate metabolic process ribonucleoside bisphosphate catabolic process organophosphate metabolic process metabolic process cellular process purine ribonucleotide metabolic process ribonucleoside bisphosphate biosynthetic process guanosine tetraphosphate biosynthetic process nucleotide biosynthetic process purine ribonucleotide biosynthetic process purine ribonucleoside bisphosphate biosynthetic process ribonucleotide biosynthetic process guanosine tetraphosphate metabolic process purine-containing compound biosynthetic process purine nucleoside bisphosphate biosynthetic process ribose phosphate biosynthetic process carbohydrate derivative biosynthetic process nucleoside bisphosphate biosynthetic process nucleobase-containing compound biosynthetic process biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process purine nucleotide biosynthetic process nucleobase-containing small molecule interconversion response to nutrient levels response to stimulus response to stress response to starvation	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR050273	GppA/Ppx guanosine pentaphosphate hydrolase	Family
A, B, C, D	IPR048950	Ppx/GppA phosphatase, C-terminal	Domain
A, B, C, D	IPR030673	Pyrophosphatase, GppA/Ppx-type	Family
A, B, C, D	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A, B, C, D	IPR023709	Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase	Family
A, B, C, D	IPR003695	Ppx/GppA phosphatase, N-terminal	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.