6O07

Structure and mechanism of acetylation by the N-terminal dual enzyme NatA/Naa50 complex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A [auth C]	d6o07c_	Alpha and beta proteins (a+b)	Acyl-CoA N-acyltransferases (Nat)	Acyl-CoA N-acyltransferases (Nat)	automated matches	automated matches	Baker's yeast (Saccharomyces cerevisiae ) [TaxId: 4932 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth B]	SCOP2B Superfamily	Acyl-CoA N-acyltransferases (Nat)	8101495	3000403	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth C]	Acetyltransf_10_6	e6o07C1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_6	ECOD (1.6)
B [auth A]	TPR_15	e6o07A1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: TPR_15	ECOD (1.6)
C [auth B]	Acetyltransf_10_5	e6o07B1	A: a+b three layers	X: Nat/Ivy	H: Acyl-CoA N-acyltransferases (Nat) (From Topology)	T: Acyl-CoA N-acyltransferases (Nat)	F: Acetyltransf_10_5	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth C]	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (utative)
C [auth B]	3.40.630.30	Alpha Beta	3-Layer(aba) Sandwich	Aminopeptidase	Gcn5-related N-acetyltransferase (GNAT)	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth C]	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family
B [auth A]	PF12569	N-terminal acetyltransferase A, auxiliary subunit (NatA_aux_su)	N-terminal acetyltransferase A, auxiliary subunit	-	Repeat
C [auth B]	PF00583	Acetyltransferase (GNAT) family (Acetyltransf_1)	Acetyltransferase (GNAT) family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth C]	N-terminal acetyltransferase A complex subunit NAT5	acetyltransferase activity N-acetyltransferase activity acyltransferase activity peptide alpha-N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity peptide N-acetyltransferase activity catalytic activity N-acyltransferase activity peptide-methionine-alpha-N-acetyltransferase activity	cellular component organization organelle organization mitotic sister chromatid cohesion chromosome organization sister chromatid cohesion cellular process cellular component organization or biogenesis cell cycle cell cycle process	protein-containing complex intracellular anatomical structure NatA complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex cellular anatomical structure protein acetyltransferase complex cytoplasm intracellular protein-containing complex
B [auth A]	Naa15	ribonucleoprotein complex binding protein-containing complex binding binding ribosome binding	-	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex NatA complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex NatA complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex protein acetyltransferase complex intracellular protein-containing complex
C [auth B]	N-terminal acetyltransferase A complex catalytic subunit ARD1	acetyltransferase activity N-acetyltransferase activity acyltransferase activity peptide-serine-alpha-N-acetyltransferase activity peptide alpha-N-acetyltransferase activity acyltransferase activity, transferring groups other than amino-acyl groups transferase activity peptide N-acetyltransferase activity catalytic activity N-acyltransferase activity peptide-glutamate-alpha-N-acetyltransferase activity identical protein binding protein binding binding	primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation metabolic process cellular process protein metabolic process macromolecule metabolic process primary metabolic process gene expression macromolecule biosynthetic process protein acylation protein maturation protein acetylation biosynthetic process N-terminal protein amino acid modification macromolecule modification N-terminal protein amino acid acetylation metabolic process cellular process protein metabolic process macromolecule metabolic process protein modification process	protein-containing complex intracellular anatomical structure NatA complex catalytic complex N-terminal protein acetyltransferase complex transferase complex acetyltransferase complex cellular anatomical structure protein acetyltransferase complex cytoplasm intracellular protein-containing complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth C]	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
A [auth C]	IPR000182	GNAT domain	Domain
A [auth C]	IPR051556	N-terminal and lysine N-acetyltransferase	Family
B [auth A]	IPR021183	N-terminal acetyltransferase A, auxiliary subunit	Family
B [auth A]	IPR011990	Tetratricopeptide-like helical domain superfamily	Homologous Superfamily
B [auth A]	IPR019734	Tetratricopeptide repeat	Repeat
C [auth B]	IPR045047	N-acetyltransferase Ard1-like	Family
C [auth B]	IPR016181	Acyl-CoA N-acyltransferase	Homologous Superfamily
C [auth B]	IPR000182	GNAT domain	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.