6JO8 | pdb_00006jo8

The complex structure of CHIKV envelope glycoprotein bound to human MXRA8

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Alpha_E2_glycop_2nd	e6jo8A2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
A	Alpha_E2_glycop_1st	e6jo8A1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
A	Alpha_E2_glycop_3rd	e6jo8A3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
A	Alpha_E3_glycop	e6jo8A4	A: a+b two layers	X: Glycoprotein E3 (From Topology)	H: Glycoprotein E3 (From Topology)	T: Glycoprotein E3	F: Alpha_E3_glycop	ECOD (1.6)
C	Alpha_E2_glycop_2nd	e6jo8C1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
C	Alpha_E2_glycop_1st	e6jo8C3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
C	Alpha_E2_glycop_3rd	e6jo8C2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
E	Alpha_E2_glycop_2nd	e6jo8E2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_2nd	ECOD (1.6)
E	Alpha_E2_glycop_1st	e6jo8E3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_1st	ECOD (1.6)
E	Alpha_E2_glycop_3rd	e6jo8E1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E2_glycop_3rd	ECOD (1.6)
B	Alpha_E1_glycop_2nd	e6jo8B1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
B	Alpha_E1_glycop_1st	e6jo8B2	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
D	Alpha_E1_glycop_2nd	e6jo8D2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
D	Alpha_E1_glycop_1st	e6jo8D1	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
F	Alpha_E1_glycop_2nd	e6jo8F2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Alpha_E1_glycop_2nd	ECOD (1.6)
F	Alpha_E1_glycop_1st	e6jo8F1	A: beta complex topology	X: Viral glycoprotein, central and dimerisation domains-like	H: Viral glycoprotein, central and dimerisation domains (From Topology)	T: Viral glycoprotein, central and dimerisation domains	F: Alpha_E1_glycop_1st	ECOD (1.6)
G [auth M]	I-set_6	e6jo8M2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_6	ECOD (1.6)
G [auth M]	I-set_7	e6jo8M1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_7	ECOD (1.6)
H [auth N]	I-set_6	e6jo8N1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_6	ECOD (1.6)
H [auth N]	I-set_7	e6jo8N2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_7	ECOD (1.6)
I [auth O]	I-set_6	e6jo8O1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_6	ECOD (1.6)
I [auth O]	I-set_7	e6jo8O2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: I-set_7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.287.2230	Mainly Alpha	Orthogonal Bundle	Helix Hairpins		CATH (utative)
A	2.60.40.3200	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, A domain	CATH (utative)
A	2.60.40.4310	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, domain B	CATH (utative)
A	2.60.40.2400	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, domain C	CATH (utative)
C	2.60.40.3200	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, A domain	CATH (utative)
C	2.60.40.4310	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, domain B	CATH (utative)
C	2.60.40.2400	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, domain C	CATH (utative)
E	2.60.40.3200	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, A domain	CATH (utative)
E	2.60.40.4310	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, domain B	CATH (utative)
E	2.60.40.2400	Mainly Beta	Sandwich	Immunoglobulin-like	Alphavirus E2 glycoprotein, domain C	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C, E	PF00943	Alphavirus E2 glycoprotein (Alpha_E2_glycop)	Alphavirus E2 glycoprotein	-	Family
A, C, E	PF01563	Alphavirus E3 glycoprotein (Alpha_E3_glycop)	Alphavirus E3 glycoprotein	-	Family
B, D, F	PF01589	Alphavirus E1 glycoprotein (Alpha_E1_glycop)	Alphavirus E1 glycoprotein	-	Family
G [auth M], H [auth N], I [auth O]	PF07686	Immunoglobulin V-set domain (V-set)	Immunoglobulin V-set domain	This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C, E	Togavirin	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity structural molecule activity	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host proteolysis metabolic process viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host proteolysis metabolic process cellular process primary metabolic process protein metabolic process macromolecule metabolic process	cellular anatomical structure membrane virion component virion membrane viral capsid icosahedral viral capsid T=4 icosahedral viral capsid host cell plasma membrane host cellular component host cell part host cell membrane host intracellular part host cell cytoplasm host intracellular region
B, D, F	CHIKV E1	peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity structural molecule activity	viral process fusion of virus membrane with host endosome membrane membrane fusion involved in viral entry into host cell virion attachment to host cell biological process involved in interspecies interaction between organisms adhesion of symbiont to host cell viral life cycle adhesion of symbiont to host biological process involved in interaction with host biological process involved in symbiotic interaction symbiont entry into host cell symbiont entry into host	host cellular component cellular anatomical structure host cell membrane virion component virion membrane viral capsid host cell part host cell membrane
G [auth M], H [auth N], I [auth O]	Matrix remodeling-associated protein 8	-	developmental process cellular developmental process cell differentiation cellular process cell adhesion multicellular organismal process establishment of blood-brain barrier cell development nervous system development glial cell development establishment of glial blood-brain barrier multicellular organism development neurogenesis central nervous system development developmental process cellular developmental process cell differentiation cellular process cell adhesion multicellular organismal process establishment of blood-brain barrier cell development nervous system development glial cell development establishment of glial blood-brain barrier multicellular organism development neurogenesis central nervous system development gliogenesis glial cell differentiation anatomical structure development system development	membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle cellular anatomical structure organelle lumen organelle endoplasmic reticulum cytoplasm extracellular exosome membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle cellular anatomical structure organelle lumen organelle endoplasmic reticulum cytoplasm extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cell surface cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction cell junction nucleus membrane plasma membrane cilium ciliary membrane plasma membrane bounded cell projection cell periphery cell projection bounding membrane of organelle plasma membrane region organelle membrane cell projection membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C, E	IPR002533	Alphavirus E3 spike glycoprotein	Domain
A, C, E	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A, C, E	IPR042305	Alphavirus E2 glycoprotein, domain B	Homologous Superfamily
A, C, E	IPR042306	Alphavirus E2 glycoprotein, domain C	Homologous Superfamily
A, C, E	IPR000936	Alphavirus E2 glycoprotein	Family
A, C, E	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
A, C, E	IPR000930	Peptidase S3, togavirin	Domain
A, C, E	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A, C, E	IPR042304	Alphavirus E2 glycoprotein, domain A	Homologous Superfamily
A, C, E	IPR002548	Alphavirus E1 glycoprotein	Domain
A, C, E	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
A, C, E	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
A, C, E	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
B, D, F	IPR000936	Alphavirus E2 glycoprotein	Family
B, D, F	IPR038055	Flaviviral glycoprotein E, dimerisation domain	Homologous Superfamily
B, D, F	IPR014756	Immunoglobulin E-set	Homologous Superfamily
B, D, F	IPR002548	Alphavirus E1 glycoprotein	Domain
B, D, F	IPR000336	Flavivirus/Alphavirus glycoprotein, immunoglobulin-like domain superfamily	Homologous Superfamily
B, D, F	IPR036253	Flavivirus glycoprotein, central and dimerisation domain superfamily	Homologous Superfamily
G [auth M], H [auth N], I [auth O]	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
G [auth M], H [auth N], I [auth O]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
G [auth M], H [auth N], I [auth O]	IPR042472	Matrix remodeling-associated protein 8	Family
G [auth M], H [auth N], I [auth O]	IPR013106	Immunoglobulin V-set domain	Domain
G [auth M], H [auth N], I [auth O]	IPR003599	Immunoglobulin domain subtype	Domain
G [auth M], H [auth N], I [auth O]	IPR007110	Immunoglobulin-like domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
G [auth M], H [auth N], I [auth O]	Pharos: Q9BRK3	breast carcinoma invasive ductal breast carcinoma malignant pancreatic neoplasm pancreatic ductal adenocarcinoma subependymal giant cell astrocytoma inflammatory bowel disease malignant ependymoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma ulcerative colitis interstitial lung disease malignant mesothelioma ovarian cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia