6IUR | pdb_00006iur

A phosphatase complex STRN3-PP2Aa

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	ARM repeat-like	8038568	3000116	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	ARM repeat-like	8038568	3000116	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	ARM repeat-like	8038568	3000116	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	ARM repeat-like	8038568	3000116	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	CLASP_N_1	e6iurA1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: CLASP_N_1	ECOD (1.6)
B	CLASP_N_1	e6iurB1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: CLASP_N_1	ECOD (1.6)
E	CLASP_N_1	e6iurE1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: CLASP_N_1	ECOD (1.6)
F	CLASP_N_1	e6iurF1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: CLASP_N_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (utative)
B	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (utative)
E	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (utative)
F	1.25.10.10	Mainly Alpha	Alpha Horseshoe	Leucine-rich Repeat Variant	Leucine-rich Repeat Variant	CATH (utative)
C	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)
D	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)
G	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)
H	1.20.5.300	Mainly Alpha	Up-down Bundle	Single alpha-helices involved in coiled-coils or other helix-helix interfaces		CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, E, F	PF02985	HEAT repeat (HEAT)	HEAT repeat	-	Repeat
C, D, G, H	PF08232	Striatin family (Striatin)	Striatin family	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, E, F	PP2A scaffolding subunit	protein antigen binding protein binding binding antigen binding phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity protein antigen binding protein binding binding antigen binding phosphoric ester hydrolase activity enzyme regulator activity catalytic activity, acting on a protein phosphatase regulator activity phosphatase activity hydrolase activity phosphoprotein phosphatase activity hydrolase activity, acting on ester bonds molecular function regulator activity protein phosphatase regulator activity catalytic activity protein serine/threonine phosphatase activity protein heterodimerization activity protein dimerization activity	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein-containing complex assembly cellular process cellular component organization or biogenesis meiotic spindle elongation meiotic chromosome segregation sexual reproduction spindle elongation reproductive process microtubule cytoskeleton organization meiotic cell cycle process meiotic nuclear division cell cycle chromosome segregation spindle organization cell cycle process meiotic cell cycle organelle fission meiotic spindle organization organelle organization nuclear division nuclear chromosome segregation microtubule-based process cytoskeleton organization mitotic nuclear division chromosome organization sister chromatid segregation mitotic cell cycle mitotic cell cycle process chromosome separation mitotic sister chromatid segregation mitotic sister chromatid separation sister chromatid cohesion meiotic sister chromatid cohesion, centromeric centromeric sister chromatid cohesion meiotic sister chromatid cohesion cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signal transduction in absence of ligand signaling positive regulation of biological process regulation of signal transduction regulation of programmed cell death positive regulation of extrinsic apoptotic signaling pathway in absence of ligand extrinsic apoptotic signaling pathway cell communication positive regulation of apoptotic signaling pathway positive regulation of response to stimulus extrinsic apoptotic signaling pathway in absence of ligand signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process biological regulation positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway regulation of response to stimulus regulation of extrinsic apoptotic signaling pathway in absence of ligand regulation of cell communication apoptotic process programmed cell death regulation of apoptotic signaling pathway positive regulation of signaling regulation of growth growth multicellular organismal process multicellular organismal-level homeostasis leukocyte homeostasis T cell homeostasis homeostatic process immune system process homeostasis of number of cells lymphocyte homeostasis multicellular organismal reproductive process female gamete generation gamete generation female meiotic nuclear division hippo signaling negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process intracellular signal transduction negative regulation of cell communication regulation of intracellular signal transduction negative regulation of cellular process negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of hippo signaling regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction intracellular signaling cassette phosphatidylinositol 3-kinase/protein kinase B signal transduction meiotic cell cycle process involved in oocyte maturation cellular developmental process regulation of reproductive process cell development cellular process involved in reproduction in multicellular organism developmental process involved in reproduction oocyte development cell differentiation anatomical structure development cell maturation regulation of cell cycle developmental process regulation of cell cycle process oogenesis regulation of meiotic cell cycle process involved in oocyte maturation developmental maturation anatomical structure maturation germ cell development oocyte maturation oocyte differentiation regulation of developmental process regulation of cell differentiation	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle phosphatase complex protein-containing complex catalytic complex protein phosphatase type 2A complex protein serine/threonine phosphatase complex membrane extracellular exosome extracellular vesicle extracellular organelle extracellular region extracellular space vesicle extracellular membrane-bounded organelle cytosol membraneless organelle chromosome, centromeric region intracellular membraneless organelle chromosome chromosomal region somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection synapse cell junction glutamatergic synapse cytoskeleton microtubule cytoskeleton cell body neuronal cell body cell periphery plasma membrane lateral plasma membrane FAR/SIN/STRIPAK complex nucleus
C, D, G, H	Striatin-3	small GTPase binding protein binding binding enzyme binding GTPase binding protein phosphatase binding phosphatase binding protein phosphatase 2A binding protein-macromolecule adaptor activity molecular adaptor activity armadillo repeat domain binding protein domain specific binding protein-containing complex binding calmodulin binding	regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular process negative regulation of biological process RNA metabolic process regulation of primary metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process regulation of RNA metabolic process negative regulation of cellular process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of DNA-templated transcription regulation of biological process negative regulation of metabolic process biological regulation primary metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of gene expression biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process metabolic process cellular process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process negative regulation of RNA metabolic process cellular response to stimulus hippo signaling response to stimulus signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction signal transduction regulation of signaling negative regulation of response to stimulus negative regulation of hippo signaling negative regulation of signal transduction regulation of response to stimulus regulation of cell communication regulation of hippo signaling intracellular receptor signaling pathway response to lipid hormone-mediated signaling pathway negative regulation of intracellular steroid hormone receptor signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone regulation of intracellular steroid hormone receptor signaling pathway regulation of intracellular estrogen receptor signaling pathway nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus negative regulation of intracellular estrogen receptor signaling pathway steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus estrogen receptor signaling pathway cellular response to chemical stimulus response to chemical cellular response to lipid nuclear receptor-mediated signaling pathway transcription by RNA polymerase II regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process response to estradiol response to oxygen-containing compound	cell periphery cellular anatomical structure plasma membrane membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus cell periphery cellular anatomical structure plasma membrane membrane somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection intracellular anatomical structure cytoplasm membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen protein-containing complex Golgi apparatus endomembrane system cell body neuronal cell body FAR/SIN/STRIPAK complex postsynapse synapse cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, E, F	IPR054573	Phosphatase PP2A regulatory subunit A/Splicing factor 3B subunit 1-like, HEAT repeat	Domain
A, B, E, F	IPR016024	Armadillo-type fold	Homologous Superfamily
A, B, E, F	IPR021133	HEAT, type 2	Repeat
A, B, E, F	IPR011989	Armadillo-like helical	Homologous Superfamily
A, B, E, F	IPR051023	Protein Phosphatase 2A Regulatory Subunit A	Family
A, B, E, F	IPR000357	HEAT repeat	Repeat
C, D, G, H	IPR019775	WD40 repeat, conserved site	Conserved Site
C, D, G, H	IPR013258	Striatin, N-terminal	Domain
C, D, G, H	IPR015943	WD40/YVTN repeat-like-containing domain superfamily	Homologous Superfamily
C, D, G, H	IPR036322	WD40-repeat-containing domain superfamily	Homologous Superfamily
C, D, G, H	IPR001680	WD40 repeat	Repeat
C, D, G, H	IPR051488	WD repeat-containing striatin	Family
C, D, G, H	IPR020472	G-protein beta WD-40 repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, E, F	Pharos: P30153	microcephaly-corpus callosum hypoplasia-intellectual disability-facial dysmorphism syndrome intellectual disability Disease Exacerbation gastric neoplasm osteoarthritis hereditary diffuse gastric adenocarcinoma osteoarthritis susceptibility 1 rheumatoid arthritis gastric cancer
C, D, G, H	Pharos: Q13033	exocrine pancreatic carcinoma oligodendroglioma psoriasis malignant pancreatic neoplasm osteosarcoma myopathy ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.