Annotations: 6GX7

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Tubulin_C	e6gx7A2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
A	Tubulin	e6gx7A1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
C	Tubulin_C	e6gx7C2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
C	Tubulin	e6gx7C1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
B	Tubulin_C	e6gx7B2	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
B	Tubulin	e6gx7B1	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
D	Tubulin_C	e6gx7D1	A: a+b three layers	X: Bacillus chorismate mutase-like	H: Tubulin C-terminal domain-like (From Topology)	T: Tubulin C-terminal domain-like	F: Tubulin_C	ECOD (1.6)
D	Tubulin	e6gx7D2	A: a/b three-layered sandwiches	X: Rossmann-like	H: Rossmann-related	T: Tubulin nucleotide-binding domain-like	F: Tubulin	ECOD (1.6)
F	HEAT_2_1	e6gx7F1	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: HEAT_2_1	ECOD (1.6)
E	HEAT_2_1	e6gx7E2	A: alpha superhelices	X: Repetitive alpha hairpins	H: ARM repeat (From Topology)	T: ARM repeat	F: HEAT_2_1	ECOD (1.6)
G	EUF08002	e6gx7G1	A: alpha arrays	X: Type III secretion system domain-like	H: Type III secretion system domains (From Topology)	T: Type III secretion system domains	F: EUF08002	ECOD (1.6)
G	HrpJ	e6gx7G3	A: alpha arrays	X: Type III secretion system domain-like	H: Type III secretion system domains (From Topology)	T: Type III secretion system domains	F: HrpJ	ECOD (1.6)
G	UNK_F_TYPE	e6gx7G2	A: alpha arrays	X: Type III secretion system domain-like	H: Type III secretion system domains (From Topology)	T: Type III secretion system domains	F: UNK_F_TYPE	ECOD (1.6)
H	EUF08002	e6gx7H2	A: alpha arrays	X: Type III secretion system domain-like	H: Type III secretion system domains (From Topology)	T: Type III secretion system domains	F: EUF08002	ECOD (1.6)
H	HrpJ	e6gx7H1	A: alpha arrays	X: Type III secretion system domain-like	H: Type III secretion system domains (From Topology)	T: Type III secretion system domains	F: HrpJ	ECOD (1.6)
H	UNK_F_TYPE	e6gx7H3	A: alpha arrays	X: Type III secretion system domain-like	H: Type III secretion system domains (From Topology)	T: Type III secretion system domains	F: UNK_F_TYPE	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1440	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Tubulin/FtsZ, GTPase domain	CATH (utative)
A	3.30.1330.20	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (utative)
A	1.10.287.600	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (utative)
C	3.40.50.1440	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Tubulin/FtsZ, GTPase domain	CATH (utative)
C	3.30.1330.20	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (utative)
C	1.10.287.600	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (utative)
B	3.40.50.1440	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Tubulin/FtsZ, GTPase domain	CATH (utative)
B	3.30.1330.20	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (utative)
B	1.10.287.600	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (utative)
D	3.40.50.1440	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Tubulin/FtsZ, GTPase domain	CATH (utative)
D	3.30.1330.20	Alpha Beta	2-Layer Sandwich	60s Ribosomal Protein L30	Chain: A	CATH (utative)
D	1.10.287.600	Mainly Alpha	Orthogonal Bundle	Helix Hairpins	Helix hairpin bin	CATH (utative)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF00091	Tubulin/FtsZ family, GTPase domain (Tubulin)	Tubulin/FtsZ family, GTPase domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ...	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.	Domain
A, C	PF03953	Tubulin C-terminal domain (Tubulin_C)	Tubulin C-terminal domain	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tub ...	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).	Domain
B, D	PF00091	Tubulin/FtsZ family, GTPase domain (Tubulin)	Tubulin/FtsZ family, GTPase domain	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ...	This family includes the tubulin alpha, beta and gamma chains, as well as the bacterial FtsZ family of proteins. Members of this family are involved in polymer formation. FtsZ is the polymer-forming protein of bacterial cell division. It is part of a ring in the middle of the dividing cell that is required for constriction of cell membrane and cell envelope to yield two daughter cells. FtsZ and tubulin are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules.	Domain
B, D	PF03953	Tubulin C-terminal domain (Tubulin_C)	Tubulin C-terminal domain	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tub ...	This family includes the tubulin alpha, beta and gamma chains. Members of this family are involved in polymer formation. Tubulins are GTPases. FtsZ can polymerise into tubes, sheets, and rings in vitro and is ubiquitous in eubacteria and archaea. Tubulin is the major component of microtubules. (The FtsZ GTPases have been split into their won family).	Domain
G, H	PF22342	T3SS, Low calcium response E, third helical domain (T3SS_CopN_3rd)	T3SS, Low calcium response E, third helical domain	This domain is found in Low calcium response E from Chlamydia pneumoniae (CopN, also known as LcrE) and similar bacterial sequences. CopN is involved in the regulation of type III secretion systems (T3SSs). This protein contains three repetitions of ...	This domain is found in Low calcium response E from Chlamydia pneumoniae (CopN, also known as LcrE) and similar bacterial sequences. CopN is involved in the regulation of type III secretion systems (T3SSs). This protein contains three repetitions of a helical motif flanked by disordered N- and C-terminal extensions. This entry represents the third helical domain of this protein.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C	Tubulin alpha chain	hydrolase activity catalytic activity protein-containing complex binding binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding protein heterodimerization activity protein dimerization activity guanyl nucleotide binding GTP binding hydrolase activity catalytic activity protein-containing complex binding binding cation binding ion binding metal ion binding small molecule binding identical protein binding protein binding protein heterodimerization activity protein dimerization activity guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding structural constituent of cytoskeleton structural molecule activity	multicellular organismal process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells developmental process cerebellum morphogenesis cerebellar cortex morphogenesis head development hindbrain morphogenesis animal organ development brain development multicellular organismal process multicellular organismal-level homeostasis homeostatic process homeostasis of number of cells within a tissue anatomical structure homeostasis tissue homeostasis homeostasis of number of cells developmental process cerebellum morphogenesis cerebellar cortex morphogenesis head development hindbrain morphogenesis animal organ development brain development nervous system development cerebellar cortex development anatomical structure morphogenesis multicellular organism development cerebellum development central nervous system development metencephalon development anatomical structure development hindbrain development system development behavior system process learning or memory nervous system process cognition memory protein polymerization protein-containing complex organization microtubule cytoskeleton organization microtubule polymerization cellular component organization cellular component biogenesis organelle organization microtubule polymerization or depolymerization cellular component assembly protein-containing complex assembly cellular process microtubule-based process cellular component organization or biogenesis supramolecular fiber organization cytoskeleton organization cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to chemical cellular response to calcium ion response to calcium ion startle response neuromuscular process response to external stimulus forebrain development pallium development cerebral cortex development telencephalon development brain morphogenesis forebrain morphogenesis animal organ morphogenesis response to acid chemical response to oxygen-containing compound response to nitrogen compound response to L-glutamate response to amino acid cellular developmental process neurogenesis gliogenesis glial cell differentiation cell differentiation establishment of organelle localization cellular localization organelle transport along microtubule transport intracellular transport establishment of localization localization organelle localization establishment of localization in cell microtubule-based transport transport along microtubule cytoskeleton-dependent intracellular transport microtubule-based movement cell cycle mitotic cell cycle regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation smoothened signaling pathway cell communication signal transduction adult locomotory behavior adult behavior locomotory behavior regulation of cellular component organization regulation of synapse organization cell junction organization regulation of synapse structure or activity synapse organization regulation of biological quality response to light stimulus learning visual learning visual behavior associative learning response to radiation response to abiotic stimulus sperm motility reproductive process cilium movement involved in cell motility cilium or flagellum-dependent cell motility cilium-dependent cell motility flagellated sperm motility cilium movement cell motility exploration behavior locomotory exploration behavior protein localization establishment of protein localization nitrogen compound transport protein transport cellular macromolecule localization macromolecule localization intracellular protein transport response to mechanical stimulus biosynthetic process metabolic process macromolecule metabolic process gene expression macromolecule biosynthetic process neuron apoptotic process apoptotic process cell death programmed cell death microtubule organizing center organization centrosome cycle cell cycle process generation of neurons neuron differentiation pyramidal neuron differentiation dentate gyrus development hippocampus development limbic system development motor behavior neuron migration cell migration cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis cell projection morphogenesis neuron projection morphogenesis plasma membrane bounded cell projection organization neuron projection arborization neuron development response to peptide response to cytokine response to tumor necrosis factor	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle cell projection organelle cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection neuromuscular junction synapse cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle cell projection organelle cilium 9+2 motile cilium sperm flagellum motile cilium plasma membrane bounded cell projection neuromuscular junction synapse cell junction endosome intracellular vesicle intracellular membrane-bounded organelle recycling endosome endomembrane system intracellular organelle cytoplasmic vesicle vesicle membraneless organelle intracellular membraneless organelle chromosome condensed chromosome polymeric cytoskeletal fiber axoneme axonemal microtubule cytoplasmic microtubule plasma membrane bounded cell projection cytoplasm cytoskeleton supramolecular polymer supramolecular complex microtubule cytoskeleton ciliary plasm cytoplasmic region supramolecular fiber microtubule cell periphery plasma membrane membrane cytoplasmic ribonucleoprotein granule ribonucleoprotein granule
B, D	Tubulin beta chain	structural constituent of cytoskeleton structural molecule activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding structural constituent of cytoskeleton structural molecule activity binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding cation binding metal ion binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity	cellular process cell cycle mitotic cell cycle cellular component organization organelle organization microtubule cytoskeleton organization microtubule-based process cellular component organization or biogenesis cytoskeleton organization	cellular anatomical structure intracellular anatomical structure cytoplasm polymeric cytoskeletal fiber intracellular membraneless organelle intracellular organelle cytoskeleton organelle membraneless organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton
E, F	iiiA5 ALPHAREP	-	-	-
G, H	Low calcium response E	-	negative regulation of protein transport protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport negative regulation of biological process negative regulation of transport protein localization to extracellular region localization negative regulation of secretion regulation of secretion by cell negative regulation of protein transport protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport negative regulation of biological process negative regulation of transport protein localization to extracellular region localization negative regulation of secretion regulation of secretion by cell secretion by cell cellular macromolecule localization negative regulation of cellular process negative regulation of secretion by cell negative regulation of protein localization regulation of biological process regulation of transport secretion biological regulation regulation of establishment of protein localization establishment of protein localization to extracellular region negative regulation of establishment of protein localization export from cell regulation of protein transport protein secretion establishment of localization regulation of secretion regulation of protein secretion negative regulation of protein secretion protein transport regulation of cellular localization macromolecule localization cellular process protein secretion by the type III secretion system transmembrane transport protein transmembrane transport	cell surface cellular anatomical structure membrane outer membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
A, C	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
A, C	IPR000217	Tubulin	Family
A, C	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
A, C	IPR017975	Tubulin, conserved site	Conserved Site
A, C	IPR023123	Tubulin, C-terminal	Homologous Superfamily
A, C	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
A, C	IPR002452	Alpha tubulin	Family
A, C	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily
B, D	IPR003008	Tubulin/FtsZ, GTPase domain	Domain
B, D	IPR008280	Tubulin/FtsZ, C-terminal	Homologous Superfamily
B, D	IPR037103	Tubulin/FtsZ-like, C-terminal domain	Homologous Superfamily
B, D	IPR017975	Tubulin, conserved site	Conserved Site
B, D	IPR000217	Tubulin	Family
B, D	IPR023123	Tubulin, C-terminal	Homologous Superfamily
B, D	IPR002453	Beta tubulin	Family
B, D	IPR013838	Beta tubulin, autoregulation binding site	Binding Site
B, D	IPR018316	Tubulin/FtsZ, 2-layer sandwich domain	Domain
B, D	IPR036525	Tubulin/FtsZ, GTPase domain superfamily	Homologous Superfamily
G, H	IPR013401	Type III secretion regulator, YopN/LcrE/InvE/MxiC	Domain
G, H	IPR010812	Hypersensitivity response secretion-like, HrpJ	Domain
G, H	IPR054556	T3SS, low calcium response E, C-terminal helical domain	Domain