5YHN | pdb_00005yhn

Solution structure of the LEKTI Domain 4

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Kazal-type serine protease inhibitors	8091342	4003413	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Kazal-type serine protease inhibitors	8091343	3000605	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Kazal_1_1	e5yhnA1	A: few secondary structure elements	X: Kazal-type serine protease inhibitors-like	H: Kazal-type serine protease inhibitors (From Topology)	T: Kazal-type serine protease inhibitors	F: Kazal_1_1	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00050	Kazal-type serine protease inhibitor domain (Kazal_1)	Kazal-type serine protease inhibitor domain	Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containi ...	Usually indicative of serine protease inhibitors. However, kazal-like domains are also seen in the extracellular part of agrins, which are not known to be protease inhibitors. Kazal domains often occur in tandem arrays. Small alpha+beta fold containing three disulphides. Alignment also includes a single domain from transporters in the OATP/PGT family Swiss:P46721.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	cDNA FLJ60407, highly similar to Serine protease inhibitor Kazal-type 5	enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein serine hydrolase activity serine-type endopeptidase inhibitor activity hydrolase activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity molecular function inhibitor activity molecular function regulator activity serine-type peptidase activity serine-type endopeptidase activity enzyme regulator activity peptidase activity peptidase regulator activity catalytic activity, acting on a protein serine hydrolase activity serine-type endopeptidase inhibitor activity hydrolase activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity molecular function inhibitor activity molecular function regulator activity serine-type peptidase activity serine-type endopeptidase activity catalytic activity endopeptidase activity	developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation developmental process multicellular organismal process epithelium development epidermal cell differentiation cellular developmental process epidermis development nervous system development tissue development epithelial cell differentiation hair cell differentiation generation of neurons neurogenesis multicellular organism development neuron differentiation cell differentiation anatomical structure development cellular process system development regulation of biological process cell adhesion regulation of cellular process regulation of cell adhesion biological regulation central nervous system development cellular component organization extracellular matrix organization cellular component organization or biogenesis extracellular structure organization external encapsulating structure organization response to stimulus immune response negative regulation of response to stimulus negative regulation of immune response negative regulation of biological process regulation of response to stimulus negative regulation of immune system process immune system process regulation of immune response regulation of immune system process negative regulation of proteolysis regulation of protein metabolic process negative regulation of metabolic process primary metabolic process regulation of macromolecule metabolic process regulation of primary metabolic process regulation of proteolysis proteolysis negative regulation of cellular process metabolic process protein metabolic process macromolecule metabolic process regulation of metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process regulation of leukocyte differentiation regulation of developmental process regulation of leukocyte activation cell development regulation of cell activation mononuclear cell differentiation regulation of cell differentiation lymphocyte activation lymphocyte differentiation regulation of cell development leukocyte activation regulation of T cell differentiation T cell activation T cell differentiation regulation of multicellular organismal process regulation of lymphocyte differentiation regulation of multicellular organismal development hemopoiesis cell activation regulation of T cell activation regulation of hemopoiesis leukocyte differentiation regulation of lymphocyte activation regulation of timing of anagen molting cycle process anagen hair cycle phase skin epidermis development hair follicle development hair follicle maturation regulation of hair follicle maturation biological phase hair cycle animal organ development developmental maturation skin development anatomical structure maturation molting cycle hair cycle process regulation of humoral immune response antibacterial peptide production regulation of immune effector process response to biotic stimulus antimicrobial humoral immune response mediated by antimicrobial peptide response to bacterium negative regulation of antibacterial peptide production response to other organism negative regulation of immune effector process negative regulation of humoral immune response response to external stimulus immune effector process negative regulation of defense response to bacterium regulation of gene expression negative regulation of production of molecular mediator of immune response negative regulation of gene expression biosynthetic process defense response to other organism negative regulation of macromolecule biosynthetic process negative regulation of response to external stimulus negative regulation of defense response regulation of macromolecule biosynthetic process regulation of production of molecular mediator of immune response regulation of defense response humoral immune response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms negative regulation of response to biotic stimulus regulation of response to external stimulus regulation of antibacterial peptide production antimicrobial humoral response defense response to bacterium antimicrobial peptide production response to stress regulation of response to stress response to external biotic stimulus production of molecular mediator of immune response regulation of biosynthetic process regulation of defense response to bacterium regulation of antimicrobial humoral response defense response defense response to symbiont antibacterial humoral response gene expression macromolecule biosynthetic process negative regulation of antimicrobial humoral response regulation of antimicrobial peptide production negative regulation of biosynthetic process negative regulation of antimicrobial peptide production angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis tube development negative regulation of blood vessel morphogenesis negative regulation of developmental process negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development anatomical structure morphogenesis regulation of angiogenesis anatomical structure formation involved in morphogenesis negative regulation of multicellular organismal process	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane extracellular region perinuclear region of cytoplasm intracellular vesicle epidermal lamellar body lamellar body cytoplasmic vesicle secretory granule secretory vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR050159	Kazal-type Serine Protease Inhibitor	Family
A	IPR036058	Kazal domain superfamily	Homologous Superfamily
A	IPR002350	Kazal domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9NQ38	Netherton syndrome prostate cancer IgE responsiveness, atopic spina bifida cystic fibrosis ichthyosis inherited susceptibility to asthma malignant colon neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis esophageal adenocarcinoma ichthyosis linearis circumflexa large cell medulloblastoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma Netherton syndrome prostate cancer IgE responsiveness, atopic spina bifida cystic fibrosis ichthyosis inherited susceptibility to asthma malignant colon neoplasm pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia psoriasis esophageal adenocarcinoma ichthyosis linearis circumflexa large cell medulloblastoma malignant pancreatic neoplasm pancreatic intraductal papillary-mucinous carcinoma rhinitis hypotrichosis lung cancer nasopharyngeal carcinoma pancreatic intraductal papillary-mucinous neoplasm Prostatic Neoplasms

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.